Heterotrimeric G Proteins: Insights into the Neurobiology of Mood Disorders
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Mood disorders such as major depression and bipolar disorder are common, severe, chronic and often life-threatening illnesses. Suicide is estimated to be the cause of death in up to approximately 10-15% of individuals with mood disorders. Alterations in the signal transduction through G protein-coupled receptor (GPCR) pathways have been reported in the etiopathology of mood disorders and the suicidal behavior. In this regard, the implication of certain GPCR subtypes such as alpha(2A)-adrenoceptor has been repeatedly described using different approaches. However, several discrepancies have been recently reported in density and functional status of the heterotrimeric G proteins both in major depression and bipolar disorder. A compilation of the most relevant research topics about the implication of heterotrimeric G proteins in the etiology of mood disorders (i.e., animal models of mood disorders, studies in peripheral tissue of depressive patients, and studies in postmortem human brain of suicide victims with mood disorders) will provide a broad perspective of this potential therapeutic target field. Proposed causes of the discrepancies reported at the level of G proteins in postmortem human brain of suicide victims will be discussed.
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The fighting reaction elicited in bulls in a corrida may temporarily antagonize the mechanisms implicated in low reactivity mental states, similar to those described in major depressive disorder.
“The fighting reaction elicited in bulls in a corrida may temporarily antagonize the mechanisms implicated in low reactivity mental states, similar to those described in major depressive disorder [56].”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [56]
Heterotrimeric G-protein pathways are the main signaling pathways downstream of receptor activation and have been functionally associated with major depression and bipolar disorders.
“These routes are the main signaling pathways downstream of receptor activation and have been functionally associated with major depression and bipolar disorders [56].”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [56]
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Flagged first, then by citations
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- Authors
- Gonzalez-Maeso, J., & Meana, J.
- Affiliations
- Mount Sinai Hospital (US)
- ORCID
- Meana, J.
- Venue
- Current Neuropharmacology
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2006-04-01
- Volume
- 4
- Issue
- 2
- Pages
- 127-138
- ISSN
- 1570-159X (ISSN-L)
- PMC
- PMC2430671
- OpenAlex
- W2032985983
- Cited by
- 29
- References
- 125
- Citations by year
- 2024: 1 · 2021: 8 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Neuropharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eusko Jaurlaritza
- National Institutes of Health
- National Institute on Drug Abuse (P01DA012923)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- heterotrimeric G proteins, mood disorders, major depressive disorder, bipolar disorder, suicide, G protein-coupled receptors, alpha2A-adrenoceptor, signal transduction, postmortem brain, animal models of depression, therapeutic target
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