Molecular Mechanisms of Skeletal Muscle Insulin Resistance in Type 2 Diabetes
Abstract
Type 2 (non-insulin-dependent) diabetes mellitus afflicts millions of people worldwide and is one of the main causes of morbidity and mortality. Current therapeutic agents to treat Type 2 diabetes are insufficient and thus, newer approaches are desperately needed. Type 2 diabetes is manifested by progressive metabolic impairments in tissues such as skeletal muscle, adipose tissue and liver, such that these tissues become less responsive to insulin. Skeletal muscle is quantitatively the most important tissue involved in maintaining glucose homeostasis under insulin-stimulated conditions, and is a major site of insulin resistance in Type 2 diabetic patients. At the cellular level, glucose transport into skeletal muscle is the rate-limiting step for whole body glucose uptake and a primary site of insulin resistance in Type 2 diabetes. Thus, skeletal muscle is a key insulin target tissue that harbours intrinsic defects that impinges upon whole body glucose homeostasis. Here, we review the current knowledge of signalling events that regulate glucose transport in human skeletal muscle.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Skeletal muscle insulin resistance involves reduced insulin-stimulated glucose uptake and arises from impaired insulin signalling plus several post-receptor defects, including defective glucose transport and phosphorylation and lower glucose oxidation and glycogen synthesis.
“Insulin resistance in skeletal muscle is manifested by decreased insulin-stimulated glucose uptake and results from impaired insulin signaling and multiple post-receptor intracellular defects including impaired glucose transport, glucose phosphorylation, and reduced glucose oxidation and glycogen synthesis.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [9]
Cites
Still being checked.
Cited by
Sorted by citations
Skeletal muscle inflammation and insulin resistance in obesity
Wu, H., & Ballantyne, C. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88880 · Cited by 695 · see citing works
Pathogenesis of insulin resistance in skeletal muscle
Abdul-Ghani, M. A., & DeFronzo, R. A. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/476279 · Cited by 670 · see citing works
Ehrenborg, E., & Krook, A. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001560 · Cited by 213 · see citing works
PDK4 augments ER-mitochondria contact to dampen skeletal muscle insulin signaling during obesity
Thoudam, T., Ha, C.-M., Leem, J., Chanda, D., Park, J.-S., Kim, H.-J., Jeon, J.-H., Choi, Y.-K., Liangpunsakul, S., Huh, Y. H., et al. (2019) · Diabetes · doi:10.2337/db18-0363 · Cited by 207 · see citing works
Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells
Sun, Y., Bilan, P. J., Liu, Z., & Klip, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009523107 · Cited by 197 · see citing works
Review on rosmarinic acid extraction, fractionation and its anti-diabetic potential
Ngo, Y. L., Lau, C. H., & Chua, L. S. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.09.064 · Cited by 175 · see citing works
Type 2 diabetes mellitus: epidemiology, pathophysiology, unmet needs and therapeutical perspectives
Virally, M., Blickle, J., Girard, J. R., Halimi, S., Simon, D., & Guillausseau, P.-J. (2007) · Diabetes & Metabolism · doi:10.1016/j.diabet.2007.07.001 · Cited by 118 · see citing works
Chopra, I., Li, H. F., Wang, H., & Webster, K. A. (2012) · Diabetologia · doi:10.1007/s00125-011-2407-y · Cited by 116 · see citing works
Lasram, M. M., Dhouib, I. B., Annabi, A. B., Fazâa, S. E., & Gharbi, N. (2014) · Toxicology · doi:10.1016/j.tox.2014.04.009 · Cited by 108 · see citing works
Coker, R. H., Williams, R. H., Yeo, S. E., KORTEBEIN, P. M., Bodenner, D. L., Kern, P. A., & Evans, W. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2033 · Cited by 102 · see citing works
Liu, Y., Turdi, S., Park, T., Morris, N. J., Deshaies, Y., Xu, A., & Sweeney, G. (2012) · Diabetes · doi:10.2337/db12-0687 · Cited by 97 · see citing works
Resveratrol ameliorates metabolic disorders and insulin resistance in high-fat diet-fed mice
Gong, L., Guo, S., & Zou, Z. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117212 · Cited by 96 · see citing works
Synthesis and Mechanism of Hypoglycemic Activity of Benzothiazole Derivatives
Meltzer-Mats, E., Babai-Shani, G., Pasternak, L., Uritsky, N., Getter, T., Viskind, O., Eckel, J., Cerasi, E., Senderowitz, H., Sasson, S., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm4001488 · Cited by 95 · see citing works
Myosin phosphatase: Unexpected functions of a long-known enzyme
Kiss, A., Erdődi, F., & Lontay, B. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.07.023 · Cited by 92 · see citing works
Agarwal, P., Srivastava, R., Srivastava, R., Ali, S., & Datta, M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.03.021 · Cited by 85 · see citing works
MicroRNA-29a induces insulin resistance by targeting PPARδ in skeletal muscle cells
ZHOU, Y., Gu, P., SHI, W., Li, J., Hao, Q., Cao, X., Lu, Q., & Zeng, Y. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2499 · Cited by 79 · see citing works
Højlund, K., Birk, J. B., Klein, D. K., Levin, K., Rose, A. J., Hansen, B. F., Nielsen, J. N., Beck‐Nielsen, H., & Wojtaszewski, J. F. P. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0897 · Cited by 77 · see citing works
Vlavcheski, F., Naimi, M., Murphy, B. A., Hudlický, T., & Tsiani, E. (2017) · Molecules · doi:10.3390/molecules22101669 · Cited by 79 · see citing works
Samokhvalov, V., Bilan, P. J., Schertzer, J. D., Antonescu, C. N., & Klip, A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90667.2008 · Cited by 69 · see citing works
Martínez-López, N., Athonvarangkul, D., Sahu, S., Coletto, L., Zong, H., Bastie, C. C., Pessin, J. E., Schwartz, G. J., & Singh, R. (2013) · EMBO Reports · doi:10.1038/embor.2013.111 · Cited by 68 · see citing works
Weigert, C., Kron, M., Kalbacher, H., Pohl, A. K., Runge, H., Häring, H., Schleicher, E. D., & Lehmann, R. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0102 · Cited by 66 · see citing works
Vlavcheski, F., Baron, D. C., Vlachogiannis, I. A., MacPherson, R. E. K., & Tsiani, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051321 · Cited by 67 · see citing works
Salimifar, M., Fatehi‐Hassanabad, Z., & Fatehi, M. (2013) · Current Diabetes Reviews · doi:10.2174/15733998113099990076 · Cited by 65 · see citing works
New Evidence for the Role of Ceramide in the Development of Hepatic Insulin Resistance
Konstantynowicz-Nowicka, K., Harasim‐Symbor, E., Baranowski, M., & Chabowski, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116858 · Cited by 64 · see citing works
Acute exercise reverses aged-induced impairments in insulin signaling in rodent skeletal muscle
Pauli, J. R., Ropelle, E. R., Cintra, D. E., de Souza, C. T., da Silva, A. S. R., Moraes, J. C., Prada, P. O., Leme, J. A. C. D. A., Luciano, E., Velloso, L. A., et al. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.03.004 · Cited by 60 · see citing works
Petrie, J. R., Pearson, E. R., & Sutherland, C. D. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.11.010 · Cited by 57 · see citing works
Li, Z., Ni, C.-L., Yao, Z., Chen, L.-M., & Niu, W.-Y. (2014) · Metabolism · doi:10.1016/j.metabol.2014.05.008 · Cited by 56 · see citing works
Ji, A. T.-Q., Chang, Y.-C., Fu, Y.-J., Lee, O. K., & Ho, J. H. (2014) · Diabetes · doi:10.2337/db14-1042 · Cited by 51 · see citing works
Chauhan, P., Tamrakar, A. K., Mahajan, S. K., & Prasad, G. B. K. S. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.10.027 · Cited by 49 · see citing works
Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40
Zhang, L., Chen, Z., Wang, Y., Tweardy, D. J., & Mitch, W. E. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00480.2019 · Cited by 47 · see citing works
MiR-29 family members interact with SPARC to regulate glucose metabolism
Song, H., Ding, L., Zhang, S., & Wang, W. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.02.129 · Cited by 46 · see citing works
Iovino, S., Burkart, A., Kriauciunas, K. M., Warren, L., Hughes, K. J., Molla, M. N., Lee, Y.-K., Patti, M., & Kahn, C. R. (2014) · Diabetes · doi:10.2337/db14-0109 · Cited by 43 · see citing works
Lipotoxicity and cardiac dysfunction in mammals andDrosophila
Birse, R. T., & Bodmer, R. (2011) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2011.599830 · Cited by 43 · see citing works
Bakhtiari, N., Hosseinkhani, S., Soleimani, M., Hemmati, R., Noori-Zadeh, A., Javan, M., & Tashakor, A. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.01.010 · Cited by 40 · see citing works
Handschin, C. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05275.x · Cited by 38 · see citing works
Geetha, T., Langlais, P. R., Luo, M., Mapes, R., Lefort, N., Chen, S., Mandarino, L. J., & Yi, Z. (2011) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-010-0051-2 · Cited by 36 · see citing works
The Destiny of Glucose from a MicroRNA Perspective
Mirra, P., Nigro, C., Prevenzano, I., Leone, A., Raciti, G. A., Formisano, P., Bèguinot, F., & Miele, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00046 · Cited by 36 · see citing works
Reda, E., Hassaneen, S. K., & El-Abhar, H. S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00771 · Cited by 36 · see citing works
Li, Z., Zhu, Y., Li, C., Tang, Y., Jiang, Z., Yang, M., Ni, C., Li, D., Chen, L., & Niu, W. (2018) · Journal of Endocrinological Investigation · doi:10.1007/s40618-018-0836-x · Cited by 35 · see citing works
Park, S., Turner, K., Zheng, D., Brault, J. J., Zou, K., Chaves, A., Nielsen, T. S., Tanner, C. J., Treebak, J. T., & Houmard, J. A. (2018) · The Journal of Physiology · doi:10.1113/jp276990 · Cited by 35 · see citing works
Sequestosome 1/p62, a Scaffolding Protein, Is a Newly Identified Partner of IRS-1 Protein
Geetha, T., Chen, Z., Vishwaprakash, N., Broderick, T. L., & Babu, J. R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.322404 · Cited by 31 · see citing works
Naimi, M., Vlavcheski, F., Murphy, B. A., Hudlický, T., & Tsiani, E. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12674 · Cited by 31 · see citing works
Mohankumar, S. K., Taylor, C. G., Siemens, L., & Zahradka, P. C. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.01.006 · Cited by 31 · see citing works
Wang, W., Zhang, Y., Yang, C., Wang, Y., Shen, J., Shi, M., & Wang, B. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219839643 · Cited by 30 · see citing works
Ardavani, A., Aziz, H., Smith, K., Atherton, P. J., Phillips, B. E., & IDRIS, I. R. (2020) · Advances in Therapy · doi:10.1007/s12325-020-01562-0 · Cited by 30 · see citing works
Kaempferol improves glucose uptake in skeletal muscle via an AMPK-dependent mechanism
Moore, W. T., Luo, J., & Liu, D. (2023) · Food Science and Human Wellness · doi:10.1016/j.fshw.2023.03.028 · Cited by 24 · see citing works
Yoon, S., Lee, J. H., Kwon, S. J., Kang, H. J., & Chung, S. J. (2018) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2018.08.011 · Cited by 24 · see citing works
Terruzzi, I. M., Anna, M., Pamela, S., Fernanda, V., Benedini, S., & Luzi, L. (2016) · Endocrine · doi:10.1007/s12020-016-1181-5 · Cited by 23 · see citing works
Geetha, T., Langlais, P. R., Caruso, M. A., & Yi, Z. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0145 · Cited by 22 · see citing works
Park, J. E., Seo, Y., & Han, J.-S. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153473 · Cited by 21 · see citing works
Development of Insulin Resistance through Induction of miRNA-135 in C2C12 Cells.
Honardoost, M., Arefian, E., Soleimani, M., Soudi, S., & Sarookhani, M. R. (2016) · PubMed Central · doi:10.22074/cellj.2016.4563 · Cited by 21 · see citing works
Wone, B. W. M., Donovan, E. R., Cushman, J. C., & Hayes, J. P. (2013) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2013.02.010 · Cited by 20 · see citing works
Duranti, G., Maldini, M., Crognale, D., Sabatini, S., Corana, F., Horner, K. M., & Ceci, R. (2020) · Phytomedicine Plus · doi:10.1016/j.phyplu.2020.100014 · Cited by 19 · see citing works
Fan, D., Wang, Y., Liu, B., & Yin, F. (2022) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000000807 · Cited by 19 · see citing works
Lee, M. J., Khang, A. R., Yi, D., & Kang, Y. H. (2022) · PLoS ONE · doi:10.1371/journal.pone.0275746 · Cited by 18 · see citing works
Physical exercise and pancreatic islets
Almeida, F. N., de Proença, A. R. G., Chimin, P., Marçal, A. C., Lima, F. B., & Carvalho, C. R. D. O. (2012) · Islets · doi:10.4161/isl.21273 · Cited by 18 · see citing works
Intracellular pH Regulation of Skeletal Muscle in the Milieu of Insulin Signaling
Posa, D. K., & Baba, S. P. (2020) · Nutrients · doi:10.3390/nu12102910 · Cited by 18 · see citing works
Vanillin modulates activities linked to dysmetabolism in psoas muscle of diabetic rats
Salau, V. F., Erukainure, O. L., Olofinsan, K. A., Ijomone, O. M., Msomi, N. Z., & Islam, M. S. (2021) · Scientific Reports · doi:10.1038/s41598-021-98158-7 · Cited by 17 · see citing works
Bakar, M. H. A., Shahril, N. S. N., Khalid, M. S. F. M., Mohammad, S., Shariff, K. A., Karunakaran, T., Salleh, R. M., & Rosdi, M. N. M. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116099 · Cited by 17 · see citing works
Research status of the effects of natural oligosaccharides on glucose metabolism
Zhang, M., Chen, Y., Chen, R., Wen, Y., Huang, Q., Liu, Y., & Zhao, C. (2022) · eFood · doi:10.1002/efd2.54 · Cited by 16 · see citing works
Wu, P., Wang, Q., Jiang, C., Chen, C., Liu, Y., Chen, Y., & Zeng, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8902 · Cited by 16 · see citing works
Zaheri, Z., Fahremand, F., Rezvani, M. E., Karimollah, A., & Moradi, A. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103430 · Cited by 16 · see citing works
Farrugia, M. A., Garf, S. L., Chierici, A. P., Piche, T., Gual, P., Iannelli, A., & Anty, R. (2023) · Metabolites · doi:10.3390/metabo13030330 · Cited by 16 · see citing works
Sixty Years of Drug Discovery for Type 2 Diabetes: Where Are We Now?
Clapham, J. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9882-1_1 · Cited by 13 · see citing works
Mohankumar, S. K., Taylor, C. G., & Zahradka, P. C. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.09.014 · Cited by 15 · see citing works
Cysteine- and glycine-rich protein 3 regulates glucose homeostasis in skeletal muscle
Hernandez, A. M., Weber, N., LaBarge, S. A., Peterka, V., Doan, N. Y. T., Schenk, S., & Osborn, O. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00435.2017 · Cited by 14 · see citing works
Tiliroside-derivatives enhance GLUT4 translocation via AMPK in muscle cells
Shi, L., Qin, N., Hu, L., Liu, L., Duan, H., & Niu, W. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.02.009 · Cited by 14 · see citing works
High tissue-sodium associates with systemic inflammation and insulin resistance in obese individuals
Ertuğlu, L. A., Sahinoz, M., Alsouqi, A., Değer, S. M., Guide, A., Stewart, T. G., Pike, M., Robinson‐Cohen, C., Akwo, E. A., Pridmore, M. D., et al. (2023) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2023.03.024 · Cited by 13 · see citing works
Tran, D., Myers, S., McGowan, C. J., Henstridge, D. C., Eri, R. D., Sonda, S., & Caruso, V. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.772925 · Cited by 12 · see citing works
Nadig, P. D., Asanaliyar, M., & Salis, K. M. (2021) · Journal of Herbmed Pharmacology · doi:10.34172/jhp.2021.38 · Cited by 10 · see citing works
Scheidel, J., Lindauer, K., Ackermann, J., & Koch, I. (2015) · Metabolites · doi:10.3390/metabo5040766 · Cited by 10 · see citing works
Shu, Y. L., Yang, X., Wei, L., Wen, C., Luo, H., Qin, T., Ma, L., Liu, Y., Wang, B., Liu, C., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117049 · Cited by 9 · see citing works
Kitaghenda, F. K., Wang, J., Li, T., Hong, J., Yao, L., & Zhu, X. (2024) · Updates in Surgery · doi:10.1007/s13304-024-01977-2 · Cited by 7 · see citing works
Ahn, D., Kwon, J., Song, S.-Y., Lee, J., Yoon, S., & Chung, S. J. (2023) · Life · doi:10.3390/life13061372 · Cited by 7 · see citing works
Yang, K., Shen, X., & Cai, W. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.011395 · Cited by 7 · see citing works
Consequences of Dicarbonyl Stress on Skeletal Muscle Proteins in Type 2 Diabetes
Ahmad, K., Shaikh, S., Lee, E. J., Lee, Y., & Choi, I. (2019) · Current Protein and Peptide Science · doi:10.2174/1389203720666191119100759 · Cited by 7 · see citing works
Adiposopathy as a key factor in the development of insulin resistance
Krasilnikova, E. I., Blagosklonnaya, Y. V., Bystrova, A. A., Баранова, Е. И., Чилашвили, М. А., Степанова, В. Л., Ryumina, I. L., & Симаненкова, А. В. (2012) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2012-18-2-164-176 · Cited by 6 · see citing works
Shi, M. Y., O’Keefe, L., Simcocks, A. C., Su, X. Q., & McAinch, A. J. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.10.012 · Cited by 6 · see citing works
Molecular mechanisms and therapeutic perspectives of luteolin on diabetes and its complications
Liang, Q., Liu, X., Xu, X., Chen, Z., Luo, T., Su, Y. R., & Xie, C. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177691 · Cited by 6 · see citing works
Tian, Y., Shi, D., Liao, H., Lu, B.-N., & Pang, Z.-R. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-01097-8 · Cited by 6 · see citing works
Hwang, D. H., Ravi, D. A., Prakash, R. L. M., Kang, C., & Kim, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168944 · Cited by 4 · see citing works
Turner, M. C., Brett, R., Saini, A. S., Stewart, C. E., & Renshaw, D. W. (2023) · Experimental Physiology · doi:10.1113/ep090564 · Cited by 4 · see citing works
Interventions Targeting Insulin Resistance in Patients with Type 1 Diabetes: A Narrative Review
Herascu, A., Avram, V. F., Gaiţă, L., Sima, A. C., Reurean‐Pintilei, D., & Timar, B. (2024) · Medicina · doi:10.3390/medicina60122067 · Cited by 5 · see citing works
Chen, D.-S., Zhu, Y.-Q., Ni, W.-J., Li, Y., Yin, G., Shao, Z.-Y., & Zhu, J. (2023) · PeerJ · doi:10.7717/peerj.15761 · Cited by 4 · see citing works
Linking Circulating Irisin and Type 2 Diabetes: A Systematic Review and Meta‐Analysis
Aminov, E., Folan, P., & Pisconti, A. (2025) · JCSM Communications · doi:10.1002/rco2.70000 · Cited by 4 · see citing works
Ursolic acid induces myoglobin expression and skeletal muscle remodeling in mice
Bakhtiari, N., Soulemani, M., Javan, M., Hemmati, R., & Hosseinkhani, S. (2015) · Cited by 3 · see citing works
Tissue-Specific Variations in Transcription Factors Elucidate Complex Immune System Regulation
Lu, H., Tang, Y.-C., & Gottlieb, A. (2022) · Genes · doi:10.3390/genes13050929 · Cited by 2 · see citing works
THE ROLE OF MACROPHAGES IN EXERCISE AND INSULIN RESISTANCE IN HUMAN SKELETAL MUSCLE
Groshong, J. S. (2013) · UKnowledge (University of Kentucky) · Cited by 2 · see citing works
Ouassou, H., Daoudi, N. E., Bouknana, S., Abdnim, R., & Bnouham, M. (2024) · Medicinal Chemistry · doi:10.2174/0115734064255060231116192839 · Cited by 1 · see citing works
Bakar, N. S., & Salleh, N. N. H. N. (2025) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-025-00896-2 · Cited by 1 · see citing works
Targeting the AMP-regulated kinase family to treat diabetes: a research update
Sun, G., & Rutter, G. A. (2011) · Diabetes Management · doi:10.2217/dmt.11.11 · Cited by 1 · see citing works
Devakrishna, K., Taj, G., & Upadhyay, S. (2024) · Annals of Phytomedicine An International Journal · doi:10.54085/ap.2024.13.1.60 · Cited by 1 · see citing works
Glucose and lipid metabolism in human skeletal muscle
Skrobuk, P. (2012) · Työväentutkimus Vuosikirja · Cited by 1 · see citing works
Effect of Adipose Differentiation-Related Protein (ADRP) on Glucose Uptake of Skeletal Muscle
Ku, Y. H., Kim, M., Kim, S., Park, H. S., Kim, H.-J., Lee, I., Shin, D. H., Chung, S. S., Park, S. G., Cho, Y. M., et al. (2009) · Korean Diabetes Journal · doi:10.4093/kdj.2009.33.3.206 · Cited by 1 · see citing works
PGC-1a in muscle links metabolism to inflammation
Handschin, C. (2009) · edoc (University of Basel) · doi:10.5451/unibas-ep33741 · Cited by 1 · see citing works
Aminov, E., Folan, P., & Pisconti, A. (2024) · bioRxiv · doi:10.1101/2024.06.29.601052 · Cited by 2 · see citing works
The role of steroid hormones in skeletal muscle metabolism
Salehzadeh, F. (2011) · Figshare
Studies on factors modulating glucose homeostasis in healthy and diabetic rats
Yassin, K. (2011) · Figshare
- Authors
- Bouzakri, K., Koistinen, H., & Zierath, J.
- Affiliations
- Karolinska Institutet (SE)
- Helsinki University Hospital (FI)
- Venue
- Current Diabetes Reviews
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2005-06-01
- Volume
- 1
- Issue
- 2
- Pages
- 167-174
- ISSN
- 1573-3998 (ISSN-L)
- OpenAlex
- W2168469188
- Cited by
- 106
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 9 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 14 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 8 · 2012: 8
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Diabetes Reviews (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- type 2 diabetes, insulin resistance, skeletal muscle, glucose transport, glucose homeostasis, insulin signaling, glucose uptake, insulin target tissues
- MeSH terms
- Adipose Tissue, Biological Transport, Diabetes Mellitus, Type 2, Glucose, Homeostasis, Humans, Hypoglycemic Agents, Insulin, Insulin Resistance, Liver, Receptor, Insulin, Muscle, Skeletal, Phosphatidylinositol 3-Kinases, Glucose Transporter Type 4
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review