Insulin signaling and glucose transport in insulin resistant human skeletal muscle
Open accessAbstract
Insulin increases glucose uptake and metabolism in skeletal muscle by signal transduction via protein phosphorylation cascades. Insulin action on signal transduction is impaired in skeletal muscle from Type 2 diabetic subjects, underscoring the contribution of molecular defects to the insulin resistant phenotype. This review summarizes recent work to identify downstream intermediates in the insulin signaling pathways governing glucose homeostasis, in an attempt to characterize the molecular mechanism accounting for skeletal muscle insulin resistance in Type 2 diabetes. Furthermore, the effects of pharmaceutical treatment of Type 2 diabetic patients on insulin signaling and glucose uptake are discussed. The identification and characterization of pathways governing insulin action on glucose metabolism will facilitate the development of strategies to improve insulin sensitivity in an effort to prevent and treat Type 2 diabetes mellitus.
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- Authors
- Karlsson, H. K. R., & Zierath, J. R.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Zierath, Juleen R.
- Venue
- Cell Biochemistry and Biophysics
- Published
- 2007-04-17
- Volume
- 48
- Issue
- 2-3
- Pages
- 103-113
- ISSN
- 1085-9195 (ISSN-L)
- 1559-0283
- OpenAlex
- W2159080529
- Cited by
- 159
- References
- 231
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 16 · 2020: 12 · 2019: 5 · 2018: 13 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 10
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Locations
- Cell Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Open Archive (Karolinska Institutet) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- insulin signaling, glucose transport, skeletal muscle, insulin resistance, type 2 diabetes, glucose uptake, signal transduction, protein phosphorylation, glucose homeostasis, antidiabetic drugs, insulin sensitivity
- MeSH terms
- Diabetes Mellitus, Type 2, Glucose, Humans, Hypoglycemic Agents, Insulin, Insulin Resistance, Models, Biological, Phosphoproteins, Signal Transduction, Muscle, Skeletal, Insulin Receptor Substrate Proteins
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