Cited by 159Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and LipoproteinsNatural Antidiabetic Agents Studies

Insulin signaling and glucose transport in insulin resistant human skeletal muscle

Open access
Karlsson, Håkan K. R., Zierath, Juleen R.·2007·Cell Biochemistry and Biophysics

Abstract

Insulin increases glucose uptake and metabolism in skeletal muscle by signal transduction via protein phosphorylation cascades. Insulin action on signal transduction is impaired in skeletal muscle from Type 2 diabetic subjects, underscoring the contribution of molecular defects to the insulin resistant phenotype. This review summarizes recent work to identify downstream intermediates in the insulin signaling pathways governing glucose homeostasis, in an attempt to characterize the molecular mechanism accounting for skeletal muscle insulin resistance in Type 2 diabetes. Furthermore, the effects of pharmaceutical treatment of Type 2 diabetic patients on insulin signaling and glucose uptake are discussed. The identification and characterization of pathways governing insulin action on glucose metabolism will facilitate the development of strategies to improve insulin sensitivity in an effort to prevent and treat Type 2 diabetes mellitus.

Integrity signals

Registry

Crossref · 10.1007/s12013-007-0030-9

Cites

236 of 236 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Karlsson, H. K. R., & Zierath, J. R.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Zierath, Juleen R.
Venue
Cell Biochemistry and Biophysics
Published
2007-04-17
Volume
48
Issue
2-3
Pages
103-113
ISSN
  • 1085-9195 (ISSN-L)
  • 1559-0283
OpenAlex
W2159080529
Cited by
159
References
231
Citations by year
2026: 1 · 2025: 3 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 16 · 2020: 12 · 2019: 5 · 2018: 13 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 10
FWCI
4.20
Type
journal article
Language
en
Open access
Locations
  • Cell Biochemistry and Biophysics (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
  • Open Archive (Karolinska Institutet) (submittedVersion, other-oa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords
insulin signaling, glucose transport, skeletal muscle, insulin resistance, type 2 diabetes, glucose uptake, signal transduction, protein phosphorylation, glucose homeostasis, antidiabetic drugs, insulin sensitivity
MeSH terms
Diabetes Mellitus, Type 2, Glucose, Humans, Hypoglycemic Agents, Insulin, Insulin Resistance, Models, Biological, Phosphoproteins, Signal Transduction, Muscle, Skeletal, Insulin Receptor Substrate Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review