Cited by 107Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and LipoproteinsAdipose Tissue and Metabolism

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Molecular Mechanisms of Skeletal Muscle Insulin Resistance in Type 2 Diabetes

Bouzakri, Karim, Koistinen, Heikki, Zierath, Juleen·2005·Current Diabetes Reviews

DOI 10.2174/1573399054022785

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Abstract

Type 2 (non-insulin-dependent) diabetes mellitus afflicts millions of people worldwide and is one of the main causes of morbidity and mortality. Current therapeutic agents to treat Type 2 diabetes are insufficient and thus, newer approaches are desperately needed. Type 2 diabetes is manifested by progressive metabolic impairments in tissues such as skeletal muscle, adipose tissue and liver, such that these tissues become less responsive to insulin. Skeletal muscle is quantitatively the most important tissue involved in maintaining glucose homeostasis under insulin-stimulated conditions, and is a major site of insulin resistance in Type 2 diabetic patients. At the cellular level, glucose transport into skeletal muscle is the rate-limiting step for whole body glucose uptake and a primary site of insulin resistance in Type 2 diabetes. Thus, skeletal muscle is a key insulin target tissue that harbours intrinsic defects that impinges upon whole body glucose homeostasis. Here, we review the current knowledge of signalling events that regulate glucose transport in human skeletal muscle.

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Authors: Bouzakri, K., Koistinen, H., & Zierath, J.
Affiliations: Karolinska Institutet (SE)
Helsinki University Hospital (FI)
ORCID: Bouzakri, Karim
Koistinen, Heikki
Zierath, Juleen
Venue: Current Diabetes Reviews
Publisher: Bentham Science Publishers Ltd.
Published: 2005-06-01
Volume: 1
Issue: 2
Pages: 167-174
ISSN: 1573-3998 (ISSN-L)
DOI: 10.2174/1573399054022785
OpenAlex: W2168469188
Cited by: 106
References: 0
Citations by year: 2026: 1 · 2025: 3 · 2024: 7 · 2023: 9 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 14 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 8 · 2012: 8
FWCI: 0.37
Type: journal article
Language: en
Open access: closed
Locations: Current Diabetes Reviews (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: type 2 diabetes, insulin resistance, skeletal muscle, glucose transport, glucose homeostasis, insulin signaling, glucose uptake, insulin target tissues
MeSH terms: Adipose Tissue, Biological Transport, Diabetes Mellitus, Type 2, Glucose, Homeostasis, Humans, Hypoglycemic Agents, Insulin, Insulin Resistance, Liver, Receptor, Insulin, Muscle, Skeletal, Phosphatidylinositol 3-Kinases, Glucose Transporter Type 4

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Molecular Mechanisms of Skeletal Muscle Insulin Resistance in Type 2 Diabetes

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