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Cited by 374Redox biology and oxidative stressCancer and biochemical researchGlutathione Transferases and Polymorphisms

Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide

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R. Buettner, Garry·2011·Anti-Cancer Agents in Medicinal Chemistry
DOI 10.2174/187152011795677544PMC PMC3131414
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Abstract

Superoxide dismutases (SOD) are considered to be antioxidant enzymes. This view came about because its substrate, superoxide, is a free radical; in the era of their discovery, 1960s – 1970s, the general mindset was that free radicals in biology must be damaging. Indeed SOD blunts the cascade of oxidations initiated by superoxide. However in the late 1970s it was observed that cancer cells that have low activity of the mitochondrial form of SOD, MnSOD, grow faster than those with higher activities of MnSOD. These observations indicated that SOD, superoxide, and hydrogen peroxide affected the basic biology of cells and tissues, not just via damaging oxidation reactions. It is now realized that superoxide and hydrogen peroxide are essential for normal cellular and organism function. MnSOD appears to be a central player in the redox biology of cells and tissues. Keywords: Superoxide dismutase, mitochondria, coenzyme Q, hydrogen peroxide, superoxide, redox environment, hypoxia inducible factor, iron, melanoma cells, reduction, xanthine oxidase, tocopherol, low-flux signaling circuits, hypoxia, histidines

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  • Significantly elevated SOD activity gives rise to increases in H2O2.

    “Significantly elevated SOD activity gives rise to increases in H 2 O 2 that if not broken down to H 2 O and O 2 by the antioxidant enzymes, GPx and catalase, lead to increase in oxidative stress [53].”

    From Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing (2016) · cites this paper as [53]

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Research works printed but not linked: 40

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Authors
R. Buettner, G.
Venue
Anti-Cancer Agents in Medicinal Chemistry
Publisher
Bentham Science Publishers Ltd.
Published
2011-05-01
Volume
11
Issue
4
Pages
341-346
ISSN
  • 1568-0118 (ISSN-L)
  • 1871-5206
DOI
10.2174/187152011795677544
PMC
PMC3131414
OpenAlex
W2059071302
Cited by
374
References
8
Citations by year
2026: 21 · 2025: 27 · 2024: 30 · 2023: 33 · 2022: 49 · 2021: 23 · 2020: 34 · 2019: 25 · 2018: 17 · 2017: 17 · 2016: 16 · 2015: 17 · 2014: 25 · 2013: 14 · 2012: 20
FWCI
1.92
Type
journal article
Language
en
Open access
Locations
  • Anti-Cancer Agents in Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of General Medical Sciences (R01GM073929)
  • National Institute of Environmental Health Sciences (P42ES013661)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
Keywords
superoxide dismutase, manganese superoxide dismutase, superoxide, hydrogen peroxide, redox biology, mitochondrial redox signaling, tumor cell proliferation, coenzyme Q10, hypoxia-inducible factor, iron, melanoma, xanthine oxidase, tocopherols, hypoxia, histidine, antioxidant enzymes
MeSH terms
Antioxidants, Free Radicals, Humans, Hydrogen Peroxide, Mitochondria, Oxidation-Reduction, Superoxides, Superoxide Dismutase

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