Effects of a 12-week aerobic exercise on markers of hypertension in men
Open accessAbstract
Introduction: This study was aimed at determining the effects of a 12-week aerobic exercise program on markers of hypertension in men. Methods: The study was of a semi-experimental design featuring repeated measurements. A total of 40 men (age range=37.9 ± 2.68) with primary hypertension were divided into two groups, namely, the exercise group (n=20) and the control group (n=20) (systolic blood pressure [SBP]: 140.531 ± 0.23, diastolic blood pressure [DBP]: 90.71 ± 0.05). The exercise group participated in a 12-week aerobic exercise program (55% to 70% of HRmax). Blood samples were taken from both groups at the baseline and at the 4th, 8th, and 12th weeks of the training program for the assessment of adiponectin, paraoxonase-1 (PON-1), and hydrogen peroxide (H2 O2 ) levels as the markers for investigation. A linear mixed model was also used to evaluate the association among the markers. Results: In the exercise group, exercise reduced the SBP and DBP at week 12 (P=0.031 and 0.023, respectively), and adiponectin increased at weeks 8 and 12 (P=0.014 and 0.001, respectively). The plasma PON-1 level showed a significant increase in all the three stages of measurement (P=0.007, 0.004, and 0.002 at weeks 4, 8, and 12, respectively), whereas the H2 O2 levels showed a significant decrease at weeks 8 and 12 (P=0.013 and 0.011, respectively). The control group exhibited significantly decreased PON-1 (P=0.003) and adiponectin (P=0.025) levels but significantly increased SBP at week 12 (P=0.032). Conclusion: The exercise-induced reduction of oxidative stress exerts a considerable effect on the reduction of blood pressure in hypertensive patients. According to our results increase in oxidative stress has the great impact on the of blood pressure.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chronic exercise (4-12 weeks) induced a rise in total plasma ApN or in the ratio between HMW/total ApN in some human cohorts: subjects with normal glucose tolerance, impaired glucose tolerance or type 2 diabetes, and in patients with hypertension.
“Likewise, chronic exercise (4–12 weeks) induced a rise in total plasma ApN or in the ratio between HMW/total ApN in some human cohorts: subjects with normal glucose tolerance, impaired glucose tolerance or type 2 diabetes, and in patients with hypertension [82,83,84].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [84]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Prevalence of Overweight and Obesity in the United States, 1999-2004
Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., & Flegal, K. M. (2006) · JAMA · doi:10.1001/jama.295.13.1549 · Cited by 8,720 · see citing works
Global burden of hypertension: analysis of worldwide data
Kearney, P. M., Whelton, M., Reynolds, K., Muntner, P., Whelton, P. K., & He, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17741-1 · Cited by 8,578 · see citing works
Compendium of Physical Activities: Classification of energy costs of human physical activities
AINSWORTH, B. E., HASKELL, W. L., LEON, A. S., JACOBS, D. R., MONTOYE, H. J., SALLIS, J. F., & PAFFENBARGER, R. S. (1993) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199301000-00011 · Cited by 4,102 · see citing works
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824 · see citing works
Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y., & Matsubara, K. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0587 · Cited by 2,081 · see citing works
Wolf-Maier, K. (2003) · JAMA · doi:10.1001/jama.289.18.2363 · Cited by 1,718 · see citing works
Scherer, P. E. (2006) · Diabetes · doi:10.2337/db06-0263 · Cited by 1,062 · see citing works
Reactive oxygen species in health and disease
Alfadda, A. A., & Sallam, R. M. (2012) · Journal of Biomedicine and Biotechnology · doi:10.1155/2012/936486 · Cited by 824 · see citing works
Ouchi, N., Kobayashi, H., Kihara, S., Kumada, M., Sato, K., Inoue, T., Funahashi, T., & Walsh, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310389200 · Cited by 759 · see citing works
Tao, L., Gao, E., Jiao, X., Yuan, Y., Li, S., Christopher, T. A., Lopez, B. L., Koch, W. J., Chan, L., Goldstein, B. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.666941 · Cited by 453 · see citing works
Adiponectin Replenishment Ameliorates Obesity-Related Hypertension
Ohashi, K., Kihara, S., Ouchi, N., Kumada, M., Fujita, K., Hiuge, A., Hibuse, T., Ryo, M., Nishizawa, H., Maeda, N., et al. (2006) · Hypertension · doi:10.1161/01.hyp.0000222368.43759.a1 · Cited by 400 · see citing works
Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide
R. Buettner, G. (2011) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152011795677544 · Cited by 374 · see citing works
Oxidative Stress and Hypertension: Current Concepts
Briones, A. M., & Touyz, R. M. (2010) · Current Hypertension Reports · doi:10.1007/s11906-010-0100-z · Cited by 344 · see citing works
Cheng, K. K. Y., Lam, K. S. L., Wang, Y., Huang, Y., Carling, D., Wu, D., Wong, C., & Xu, A. (2007) · Diabetes · doi:10.2337/db06-1580 · Cited by 318 · see citing works
Montezano, A. C. I., & Touyz, R. M. (2011) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2011.00785.x · Cited by 309 · see citing works
Review on leptin and adiponectin responses and adaptations to acute and chronic exercise
Bouassida, A., Chamari, K., Zaouali, M., Feki, Y., Zbidi, A., & Tabka, Z. (2010) · British Journal of Sports Medicine · doi:10.1136/bjsm.2008.046151 · Cited by 290 · see citing works
Prevalence of Overweight and Obesity in the United States, 2007-2012
Yang, L., & Colditz, G. A. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.2405 · Cited by 279 · see citing works
The vicious circle between oxidative stress and inflammation in atherosclerosis
Hulsmans, M., & Holvoet, P. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00978.x · Cited by 271 · see citing works
Effects of Exercise on Adiponectin: A Systematic Review
Simpson, K. A., & Singh, M. A. F. (2008) · Obesity · doi:10.1038/oby.2007.53 · Cited by 260 · see citing works
Adiponectin, Cardiovascular Function, and Hypertension
Wang, Z. V., & Scherer, P. E. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.099424 · Cited by 247 · see citing works
Aucott, L., Poobalan, A., Smith, W. C. S., Avenell, A., Jung, R., & Broom, J. (2005) · Hypertension · doi:10.1161/01.hyp.0000165680.59733.d4 · Cited by 241 · see citing works
Reversal of Cardiac Hypertrophy and Fibrosis From Pressure Overload by Tetrahydrobiopterin
Moens, A. L., Takimoto, E., Tocchetti, C. G., Chakir, K., Bedja, D., Cormaci, G., Ketner, E., Majmudar, M. D., Gabrielson, K., Halushka, M. K., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.737031 · Cited by 235 · see citing works
Effects of oxidative stress on adiponectin secretion and lactate production in 3T3-L1 adipocytes
Soares, A. F., Guichardant, M., Cozzone, D., Bernoud‐Hubac, N., Bouzaïdi-Tiali, N., Lagarde, M., & Géloën, A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.12.010 · Cited by 198 · see citing works
de Castro, M. M., Rizzi, É., Rodrigues, G. J., Ceron, C. S., Bendhack, L. M., Gerlach, R. F., & Tanus-Santos, J. E. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.02.011 · Cited by 155 · see citing works
Relationships between Inflammation, Adiponectin, and Oxidative Stress in Metabolic Syndrome
Chen, S., Yen, C., Huang, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045693 · Cited by 143 · see citing works
The paraoxonase 1, 2 and 3 in humans
Rajković, M. G., Rumora, L., & Barišić, K. (2011) · Biochemia Medica · doi:10.11613/bm.2011.020 · Cited by 141 · see citing works
Murdolo, G., Piroddi, M., Luchetti, F., Tortoioli, C., Canonico, B., Zerbinati, C., Galli, F., & Iuliano, L. (2012) · Biochimie · doi:10.1016/j.biochi.2012.12.014 · Cited by 120 · see citing works
Wang, X., Satoh, H., Kase, H., Suzuki, K., & Hattori, Y. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.04.111 · Cited by 116 · see citing works
Sharman, J. E., & Stowasser, M. (2009) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2008.10.009 · Cited by 85 · see citing works
Adiponectin as a biomarker of the metabolic syndrome in children and adolescents
Pyrżak, B., Rumińska, M., Popko, K., & Demkow, U. A. (2010) · European journal of medical research · doi:10.1186/2047-783x-15-s2-147 · Cited by 83 · see citing works
Higuchi, A., Ohashi, K., Kihara, S., Walsh, K., & Ouchi, N. (2009) · Circulation Research · doi:10.1161/circresaha.109.194506 · Cited by 76 · see citing works
Beneficial effects of exercise training after myocardial infarction require full eNOS expression
de Waard, M. C., van Haperen, R., Soullié, T., Tempel, D., de Crom, R., & Duncker, D. J. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.02.005 · Cited by 69 · see citing works
Akita, Y., Otani, H., Matsuhisa, S., Kyoi, S., Enoki, C., Hattori, R., Imamura, H., Kamihata, H., Kimura, Y., & Iwasaka, T. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01102.2006 · Cited by 61 · see citing works
Targeting paraoxonase-1 in atherosclerosis
Mackness, M., & Mackness, B. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.790367 · Cited by 58 · see citing works
Human Paraoxonase-1 Activity in Childhood Obesity and Its Relation to Leptin and Adiponectin Levels
Koncsos, P., Seres, I., Harangi, M., et al. (2010) · Pediatric Research · doi:10.1203/pdr.0b013e3181c9fb66 · Cited by 49 · see citing works
Beling, A., Rahnefeld, A., Kloetzel, P. M., & Krüger, E. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00042 · Cited by 36 · see citing works
Modulation of paraoxonase 1 and 3 expression after moderate exercise training in the rat
Romani, R., Medio, G. E. D., di Tullio, S., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800493-jlr200 · Cited by 36 · see citing works
Kim, M. J., Jeong, H. J., Kim, D. W., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086034 · Cited by 31 · see citing works
Pasqualini, L., Schillaci, G., Innocente, S., Pucci, G., Coscia, F., Siepi, D., Lupattelli, G., Ciuffetti, G., & Mannarino, E. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.03.002 · Cited by 29 · see citing works
Gackowska, L., Litwin, M., Trojanek, J., Eljaszewicz, A., Kubiszewska, I., Niemirska, A., Wierzbicka, A., & Michałkiewicz, J. (2015) · BioMed Research International · doi:10.1155/2015/742646 · Cited by 27 · see citing works
Kiel, A. M., Goodwill, A. G., Noblet, J. N., Barnard, A., Sassoon, D., & Tune, J. D. (2017) · Basic Research in Cardiology · doi:10.1007/s00395-017-0654-x · Cited by 18 · see citing works
Tsuda, K. (2010) · Journal of Obesity · doi:10.1155/2011/548140 · Cited by 17 · see citing works
Parsian, H., Eizadi, M., Khorshidi, D., et al. (2013) · Pars of Jahrom University of Medical Sciences · doi:10.29252/jmj.11.1.6 · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [26]Sies H. Oxidative stress. Elsevier; 2013.
Cited by
Sorted by citations
Adiponectin—Consideration for its Role in Skeletal Muscle Health
Krause, M. P., Milne, K. J., & Hawke, T. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071528 · Cited by 121 · see citing works
Abou-Samra, M., Selvais, C. M., Dubuisson, N., & Brichard, S. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072620 · Cited by 72 · see citing works
- Authors
- Baghaiee, B., Karimi, P., Ebrahimi, K., Dabagh Nikoo kheslat, S., Sadeghi Zali, M. H., Daneshian Moghaddam, A. M., & Sadaghian, M.
- Affiliations
- Islamic Azad University, Tehran (IR)
- Tabriz University of Medical Sciences (IR)
- Islamic Azad University Shabestar (IR)
- Corresponding author
- Baghaiee, Behrouz
- Venue
- Journal of Cardiovascular and Thoracic Research
- Publisher
- Maad Rayan Publishing Company
- Published
- 2018-09-10
- Volume
- 10
- Issue
- 3
- Pages
- 162-168
- ISSN
- 2008-5117 (ISSN-L)
- 2008-6830
- PMC
- PMC6203869
- OpenAlex
- W2898383928
- Cited by
- 14
- References
- 43
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 2
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Journal of Cardiovascular and Thoracic Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Islamic Azad University
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- aerobic exercise, essential hypertension, blood pressure reduction, adiponectin, paraoxonase 1, hydrogen peroxide, oxidative stress, men, exercise training
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
