The DOI matches its Crossref record; 150 of the 150 references it cites were found in a registry or an index.
Bioavailability and Pharmacokinetics of Genistein: Mechanistic Studies on its ADME
Open accessAbstract
Genistein, one of the most active natural flavonoids, exerts various biological effects including chemoprevention, antioxidation, antiproliferation and anticancer. More than 30 clinical trials of genistein with various disease indications have been conducted to evaluate its clinical efficacy. Based on many animals and human pharmacokinetic studies, it is well known that the most challenge issue for developing genistein as a chemoprevention agent is the low oral bioavailability, which may be the major reason relating to its ambiguous therapeutic effects and large interindividual variations in clinical trials. In order to better correlate pharmacokinetic to pharmacodynamics results in animals and clinical studies, an in-depth understanding of pharmacokinetic behavior of genistein and its ADME properties are needed. Numerous in vitro/in vivo ADME studies had been conducted to reveal the main factors contributing to the low oral bioavailability of genistein. Therefore, this review focuses on summarizing the most recent progress on mechanistic studies of genistein ADME and provides a systemic view of these processes to explain genistein pharmacokinetic behaviors in vivo. The better understanding of genistein ADME property may lead to development of proper strategy to improve genistein oral bioavailability via mechanism-based approaches.
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2 retracted
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“Genistein was extensively metabolized in intestine after oral administration and several studies showed that intestine is more important than liver on disposition of genistein [30, 70].”
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Cited by
Sharifi-Rad, J., Quispe, C., Imran, M., Rauf, A., Nadeem, M., Gondal, T. A., Ahmad, B., Atif, M., Mubarak, M. S., Sytar, O., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3268136 · Cited by 389
Gonzalez-Avila, G., Sommer, B., Mendoza-Posada, D. A., Ramos, C., Garcia-Hernandez, A. A., & Falfan-Valencia, R. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.02.010 · Cited by 373
Metadata
- Authors
- Yang, Z., Kulkarni, K., Zhu, W., & Hu, M.
- Venue
- Anti-Cancer Agents in Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2012-11-01
- Volume
- 12
- Issue
- 10
- Pages
- 1264-1280
- ISSN
- 1568-0118 (ISSN-L)
- 1871-5206
- OpenAlex
- W2015875889
- Cited by
- 270
- References
- 150
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yang, Z., Kulkarni, K., Zhu, W., & Hu, M. (2012). Bioavailability and Pharmacokinetics of Genistein: Mechanistic Studies on its ADME. Anti-Cancer Agents in Medicinal Chemistry. https://doi.org/10.2174/187152012803833107
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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