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Dietary Flavonoids: Molecular Mechanisms of Action as Anti- Inflammatory Agents
Abstract
Flavonoids are a large group of polyphenolic compounds, which are ubiquitously expressed in plants. They are grouped according to their chemical structure and function into flavonols, flavones, flavan-3-ols, anthocyanins, flavanones and isoflavones. Many of flavonoids are found in fruits, vegetables and beverages. Flavonoids have been demonstrated to have advantageous effects on human health because their anti-allergic, anti-inflammatory, anti-platelet aggregation, antitumor and anti-oxidant behavior. This report reviews the current knowledge on the molecular mechanisms of action of flavonoids as anti-inflammatory agents and also discusses the relevant patents. Keywords: Bioavailability, flavonoids, fruit, inflammation, Flavonols, Flavones, Anthocyanins, pro-inflammatory cytokines, NF-kB activation, Mitogen-Activated-Protein Kinases (MAPKs) signaling
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Citations
Cited by
Recent Advances in Potential Health Benefits of Quercetin
Aghababaei, F., & Hadidi, M. (2023) · Pharmaceuticals · doi:10.3390/ph16071020 · Cited by 616
Quercetin and Its Anti-Allergic Immune Response
Mlcek, J., Jurikova, T., Skrovankova, S., & Sochor, J. (2016) · Molecules · doi:10.3390/molecules21050623 · Cited by 466
Polyphenols, Inflammation, and Cardiovascular Disease
Tangney, C. C., & Rasmussen, H. E. (2013) · Current Atherosclerosis Reports · doi:10.1007/s11883-013-0324-x · Cited by 340
Recent discoveries of anticancer flavonoids
Raffa, D., Maggio, B., Raimondi, M. V., Plescia, F., & Daidone, G. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.07.034 · Cited by 339
Hoang, H. T., Moon, J.-Y., & Lee, Y.-C. (2021) · Cosmetics · doi:10.3390/cosmetics8040106 · Cited by 329
Metadata
- Authors
- Marzocchella, L., Fantini, M., Benvenuto, M., Masuelli, L., Tresoldi, I., Modesti, A., & Bei, R.
- Venue
- Recent Patents on Inflammation & Allergy Drug Discovery
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2011-09-01
- Volume
- 5
- Issue
- 3
- Pages
- 200-220
- ISSN
- 1872-213X (ISSN-L)
- OpenAlex
- W2099143932
- Cited by
- 181
- References
- 0
- FWCI
- 6.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Marzocchella, L., Fantini, M., Benvenuto, M., Masuelli, L., Tresoldi, I., Modesti, A., & Bei, R. (2011). Dietary Flavonoids: Molecular Mechanisms of Action as Anti- Inflammatory Agents. Recent Patents on Inflammation & Allergy Drug Discovery. https://doi.org/10.2174/187221311797264937
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