The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Quercetin and Its Anti-Allergic Immune Response
Open accessAbstract
Quercetin is the great representative of polyphenols, flavonoids subgroup, flavonols. Its main natural sources in foods are vegetables such as onions, the most studied quercetin containing foods, and broccoli; fruits (apples, berry crops, and grapes); some herbs; tea; and wine. Quercetin is known for its antioxidant activity in radical scavenging and anti-allergic properties characterized by stimulation of immune system, antiviral activity, inhibition of histamine release, decrease in pro-inflammatory cytokines, leukotrienes creation, and suppresses interleukin IL-4 production. It can improve the Th1/Th2 balance, and restrain antigen-specific IgE antibody formation. It is also effective in the inhibition of enzymes such as lipoxygenase, eosinophil and peroxidase and the suppression of inflammatory mediators. All mentioned mechanisms of action contribute to the anti-inflammatory and immunomodulating properties of quercetin that can be effectively utilized in treatment of late-phase, and late-late-phase bronchial asthma responses, allergic rhinitis and restricted peanut-induced anaphylactic reactions. Plant extract of quercetin is the main ingredient of many potential anti-allergic drugs, supplements and enriched products, which is more competent in inhibiting of IL-8 than cromolyn (anti-allergic drug disodium cromoglycate) and suppresses IL-6 and cytosolic calcium level increase.
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1 retracted
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Cited by
Recent Advances in Potential Health Benefits of Quercetin
Aghababaei, F., & Hadidi, M. (2023) · Pharmaceuticals · doi:10.3390/ph16071020 · Cited by 616
Fang, Y., Medina, D., Stockwell, R., McFadden, S., Quinn, K., Peck, M. R., Bartke, A., Hascup, K. N., & Hascup, E. R. (2021) · doi:10.1101/2021.11.08.467509 · Cited by 53
(2023) · doi:10.1007/s11357-023-00843-0 · Cited by 53
Testosterone in Males as Enhanced by Onion (Allium Cepa L.)
Banihani, S. A. (2019) · Biomolecules · doi:10.3390/biom9020075 · Cited by 41
The significance of caloric restriction mimetics as anti-aging drugs
Nassar, K., El-mekawey, D., Elmasry, A. E., Refaey, M. S., El-Sayed Ghoneim, M., & Elshaier, Y. A. M. M. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149354 · Cited by 16
Metadata
- Authors
- Mlcek, J., Jurikova, T., Skrovankova, S., & Sochor, J.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2016-05-12
- Volume
- 21
- Issue
- 5
- Pages
- 623
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2374042287
- Cited by
- 466
- References
- 89
- FWCI
- 15.21
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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