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Development of 225Ac Radiopharmaceuticals: TRIUMF Perspectives and Experiences
Open accessAbstract
BACKGROUND: The development of radiopharmaceuticals containing 225Ac for targeted alpha therapy is an active area of academic and commercial research worldwide. OBJECTIVES: Despite promising results from recent clinical trials, 225Ac-radiopharmaceutical development still faces significant challenges that must be overcome to realize the widespread clinical use of 225Ac. Some of these challenges include the limited availability of the isotope, the challenging chemistry required to isolate 225Ac from any co-produced isotopes, and the need for stable targeting systems with high radiolabeling yields. RESULTS: Here we provide a review of available literature pertaining to these challenges in the 225Acradiopharmaceutical field and also provide insight into how performed and planned efforts at TRIUMF - Canada's particle accelerator centre - aim to address these issues.
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“These radiolabelled compounds, now armed with radioactive ability, allow doctors and researchers to see, measure, and adjust what is happening in the body at the molecular level [10].”
From Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation (2024) · cites this paper as [10]
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“Further in vitro serum stability testing showed that the 225Ac-DOTA complex outperformed the rest with >90% of complexes still intact after 10 days (104).”
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Cites
Kratochwil, C., Bruchertseifer, F., Giesel, F. L., Weis, M., Verburg, F. A., Mottaghy, F. M., Kopka, K., Apostolidis, C., Haberkorn, U., & Morgenstern, A. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.178673 · Cited by 1,187
Matching chelators to radiometals for radiopharmaceuticals
Price, E. W., & Orvig, C. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60304k · Cited by 1,064
Sgouros, G., Roeske, J. C., McDevitt, M. R., Palm, S., Allen, B. J., Fisher, D. R., Brill, A. B., Song, H., Howell, R. W., & Akabani, G. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.058651 · Cited by 552
Tumor therapy with targeted atomic nanogenerators.
McDevitt, M. R., Ma, D., Lai, L. T., Simon, J., Borchardt, P., Frank, R. K., Wu, K., Pellegrini, V., Curcio, M. J., Miederer, M., et al. (2001) · Science · doi:10.1126/science.1064126 · Cited by 501
Kratochwil, C., Giesel, F. L., Bruchertseifer, F., Mier, W., Apostolidis, C., Boll, R. A., Murphy, K., Haberkorn, U., & Morgenstern, A. (2014) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-014-2857-9 · Cited by 418
Radioimmunotherapy with alpha-emitting nuclides
McDevitt, M. R., Sgouros, G., Finn, R. D., Humm, J. L., Jurcic, J. G., Larson, S. M., & Scheinberg, D. A. (1998) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s002590050306 · Cited by 403
An overview of targeted alpha therapy
Kim, Y., & Brechbiel, M. W. (2011) · Tumor Biology · doi:10.1007/s13277-011-0286-y · Cited by 280
Tumour targeting with radiometals for diagnosis and therapy
Ramogida, C. F., & Orvig, C. (2013) · Chemical Communications · doi:10.1039/c3cc41554f · Cited by 268
Self-citationA Critical Review of Alpha Radionuclide Therapy—How to Deal with Recoiling Daughters?
de Kruijff, R. M., Wolterbeek, H. T., & Denkova, A. G. (2015) · Pharmaceuticals · doi:10.3390/ph8020321 · Cited by 254
Design and synthesis of 225Ac radioimmunopharmaceuticals.
McDevitt, M. R., Ma, D., Simon, J., Frank, R. K., & Scheinberg, D. A. (2002) · Applied Radiation and Isotopes · doi:10.1016/s0969-8043(02)00167-7 · Cited by 225
The promise of targeted {alpha}-particle therapy.
Mulford, D. A., Scheinberg, D. A., & Jurcic, J. G. (2005) · PubMed · Cited by 223
Molecular Pathways: Targeted α-Particle Radiation Therapy
Baidoo, K. E., Yong, K. J., & Brechbiel, M. W. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0298 · Cited by 219
Production of Ac-225 from Th-229 for Targeted α Therapy
Apostolidis, C., Molinet, R., Rasmussen, G., & Morgenstern, A. (2005) · Analytical Chemistry · doi:10.1021/ac0580114 · Cited by 215
Miederer, M., Scheinberg, D. A., & McDevitt, M. R. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.04.009 · Cited by 210
Cordier, D., Forrer, F., Bruchertseifer, F., Morgenstern, A., Apostolidis, C., Good, S., Müller‐Brand, J., Mäcke, H. R., Reubi, J. C., & Merlo, A. (2010) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-010-1385-5 · Cited by 208
The Potential and Hurdles of Targeted Alpha Therapy – Clinical Trials and Beyond
Elgqvist, J., Frost, S. H. L., Pouget, J., & Albertsson, P. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2013.00324 · Cited by 198
Apostolidis, C., Molinet, R., McGinley, J., Abbas, K., Möllenbeck, J., & Morgenstern, A. (2005) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2004.06.013 · Cited by 176
Production of actinium-225 for alpha particle mediated radioimmunotherapy.
Boll, R. A., Malkemus, D., & Mirzadeh, S. (2005) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2004.12.003 · Cited by 171
Cancer radioimmunotherapy with alpha-emitting nuclides
Couturier, O., Supiot, S., Mougin‐Degraef, M., Faivre-Chauvet, A., Carlier, T., Chatal, J., Davodeau, F., & Chérel, M. (2005) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-005-1803-2 · Cited by 169
Targeted α-therapy–past, present, future?
Brechbiel, M. W. (2007) · Dalton Transactions · doi:10.1039/b704726f · Cited by 151
Graf, F., Fahrer, J., Maus, S., Morgenstern, A., Bruchertseifer, F., Venkatachalam, S., Fottner, C., Weber, M. M., Huelsenbeck, J., Schreckenberger, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088239 · Cited by 143
Bäck, T. A., & Jacobsson, L. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.077578 · Cited by 131
Improved in Vivo Stability of Actinium-225 Macrocyclic Complexes
Deal, K. A., Davis, I. A., Mirzadeh, S., Kennel, S. J., & Brechbiel, M. W. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm990141f · Cited by 130
Morgenstern, A., Bruchertseifer, F., & Apostolidis, C. (2012) · Current Radiopharmaceuticals · doi:10.2174/1874471011205030221 · Cited by 129
Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy
McLaughlin, M. F., Woodward, J. D., Boll, R. A., Wall, J. S., Rondinone, A. J., Kennel, S. J., Mirzadeh, S., & Robertson, J. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054531 · Cited by 123
Griswold, J. R., Medvedev, D., Engle, J. W., Copping, R., Fitzsimmons, J., Radchenko, V., Cooley, J. C., Fassbender, M. E., Denton, D. L., Murphy, K. E., et al. (2016) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2016.09.026 · Cited by 116
Self-citationBandekar, A., Zhu, C., Jindal, R., Bruchertseifer, F., Morgenstern, A., & Sofou, S. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.113.125476 · Cited by 112
Radchenko, V., Engle, J. W., Wilson, J. J., Maassen, J. R., Nortier, F. M., Taylor, W. A., Birnbaum, E. R., Hudston, L. A., John, K. D., & Fassbender, M. E. (2014) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.12.045 · Cited by 111
Self-citationLaPO4 Nanoparticles Doped with Actinium-225 that Partially Sequester Daughter Radionuclides
Woodward, J. D., Kennel, S. J., Stuckey, A. C., Osborne, D., Wall, J. S., Rondinone, A. J., Standaert, R. F., & Mirzadeh, S. (2011) · Bioconjugate Chemistry · doi:10.1021/bc100574f · Cited by 111
Ballangrud, Å., Yang, W.-H., Palm, S., Enmon, R. M., Borchardt, P. E., Pellegrini, V., McDevitt, M. R., Scheinberg, D. A., & Sgouros, G. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0800 · Cited by 106
Comparison of 225actinium chelates: tissue distribution and radiotoxicity
Davis, I. A., Glowienka, K. A., Boll, R. A., Deal, K. A., Brechbiel, M. W., Stabin, M. G., Bochsler, P. N., Mirzadeh, S., & Kennel, S. J. (1999) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(99)00024-4 · Cited by 105
The iQID camera: An ionizing-radiation quantum imaging detector
Miller, B. W., Gregory, S., Fuller, E. S., Barrett, H. H., Barber, H. B., & Furenlid, L. R. (2014) · Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment · doi:10.1016/j.nima.2014.05.070 · Cited by 99
Spectroscopic and computational investigation of actinium coordination chemistry
Ferrier, M. G., Batista, E. R., Berg, J. M., Birnbaum, E. R., Cross, J. N., Engle, J. W., Pierre, H. S. L., Kozimor, S. A., Lezama-Pacheco, J. S., Stein, B. W., et al. (2016) · Nature Communications · doi:10.1038/ncomms12312 · Cited by 99
Efforts to Control the Errant Products of a Targeted In vivo Generator
Singh Jaggi, J., Kappel, B. J., McDevitt, M. R., Sgouros, G., Flombaum, C. D., Cabassa, C., & Scheinberg, D. A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3096 · Cited by 98
225Ac and 223Ra production via 800MeV proton irradiation of natural thorium targets
Weidner, J. W., Mashnik, S. G., John, K. D., Ballard, B. D., Birnbaum, E. R., Bitteker, L. J., Couture, A. J., Fassbender, M. E., Goff, G. S., Gritzo, R. E., et al. (2012) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2012.07.003 · Cited by 97
Weidner, J. W., Mashnik, S. G., John, K. D., Hemez, F., Ballard, B. D., Bach, H., Birnbaum, E. R., Bitteker, L. J., Couture, A. J., Dry, D., et al. (2012) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2012.07.006 · Cited by 97
Allen, B., Singla, A. A., Rizvi, S. M. A., Graham, P., Bruchertseifer, F., Apostolidis, C., & Morgenstern, A. (2011) · Immunotherapy · doi:10.2217/imt.11.97 · Cited by 93
Maguire, W. F., McDevitt, M. R., Smith-Jones, P. M., & Scheinberg, D. A. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.114.138347 · Cited by 93
Chappell, L. L., Deal, K. A., Dadachova, E., & Brechbiel, M. W. (2000) · Bioconjugate Chemistry · doi:10.1021/bc990153f · Cited by 82
Miller, B. W., Frost, S. H. L., Frayo, S. L., Kenoyer, A. L., Santos, E. B., Jones, J. C., Green, D. J., Hamlin, D. K., Wilbur, D. S., Fisher, D. R., et al. (2015) · Medical Physics · doi:10.1118/1.4921997 · Cited by 80
Pandya, D. N., Hantgan, R. R., Budzevich, M. M., Kock, N. D., Morse, D. L., Batista, I., Mintz, A., Li, K. C., & Wadas, T. J. (2016) · Theranostics · doi:10.7150/thno.14338 · Cited by 80
Essler, M., Gärtner, F. C., Neff, F., Blechert, B., Senekowitsch–Schmidtke, R., Bruchertseifer, F., Morgenstern, A., & Seidl, C. (2012) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-011-2023-6 · Cited by 75
Multi-isotope SPECT imaging of the 225 Ac decay chain: feasibility studies
Robertson, A. K. H., Ramogida, C. F., Rodríguez‐Rodríguez, C., Blinder, S. A. L., Kunz, P., Sossi, V., & Schaffer, P. C. (2017) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa6a99 · Cited by 75
Self-citationSynthesis and Characterization of the Actinium Aquo Ion
Ferrier, M. G., Stein, B. W., Batista, E. R., Berg, J. M., Birnbaum, E. R., Engle, J. W., John, K. D., Kozimor, S. A., Lezama-Pacheco, J. S., & Redman, L. N. (2017) · ACS Central Science · doi:10.1021/acscentsci.6b00356 · Cited by 74
Targeted Alpha-Particle Immunotherapy for Acute Myeloid Leukemia
Jurcic, J. G., & Rosenblat, T. L. (2014) · American Society of Clinical Oncology Educational Book · doi:10.14694/edbook_am.2014.34.e126 · Cited by 72
Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles
Wang, G., de Kruijff, R. M., Rol, M. A., Thijssen, L., Mendes, E., Morgenstern, A., Bruchertseifer, F., Stuart, M. C. A., Wolterbeek, H. T., & Denkova, A. G. (2013) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2013.12.008 · Cited by 64
Production of Ac-225 for cancer therapy by photon-induced transmutation of Ra-226
Melville, G., Meriarty, H., Metcalfe, P. E., Knittel, T., & Allen, B. (2007) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2007.03.018 · Cited by 60
Simultaneous Separation of Actinium and Radium Isotopes from a Proton Irradiated Thorium Matrix
Mastren, T., Radchenko, V., Owens, A., Copping, R., Boll, R. A., Griswold, J. R., Mirzadeh, S., Wyant, L. E., Brugh, M., Engle, J. W., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08506-9 · Cited by 60
Self-citationReactor production of Thorium-229
Hogle, S. L., Boll, R. A., Murphy, K., Denton, D., Owens, A., Haverlock, T. J., Garland, M. A., & Mirzadeh, S. (2016) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2016.05.002 · Cited by 57
Chemical and Radiochemical Considerations in Radiolabeling with α-Emitting Radionuclides
Wilbur, D. S. (2011) · Current Radiopharmaceuticals · doi:10.2174/1874471011104030214 · Cited by 55
Production of medical radionuclides in Russia: Status and future—a review
Zhuikov, B. L. (2013) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2013.11.025 · Cited by 51
Cyclotron and linac production of Ac-225
Melville, G., & Allen, B. (2008) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2008.11.012 · Cited by 43
Modelling and Dosimetry for Alpha-Particle Therapy
Sgouros, G., Hobbs, R. F., & Hong, S. (2011) · Current Radiopharmaceuticals · doi:10.2174/1874471011104030261 · Cited by 43
Encapsulation of α-Particle–Emitting225Ac3+Ions Within Carbon Nanotubes
Matson, M. L., Villa, C. H., Ananta, J. S., Law, J. J., Scheinberg, D. A., & Wilson, L. J. (2015) · Journal of Nuclear Medicine · doi:10.2967/jnumed.115.158311 · Cited by 43
Utilizing High-Energy γ-Photons for High-Resolution 213 Bi SPECT in Mice
de Swart, J., Chan, H. S., Goorden, M. C., Morgenstern, A., Bruchertseifer, F., Beekman, F. J., de Jong, M., & Konijnenberg, M. (2015) · Journal of Nuclear Medicine · doi:10.2967/jnumed.115.157685 · Cited by 37
Antczak, C., Jaggi, J. S., LeFave, C. V., Curcio, M. J., McDevitt, M. R., & Scheinberg, D. A. (2006) · Bioconjugate Chemistry · doi:10.1021/bc060156+ · Cited by 35
Zhu, C., Bandekar, A., Sempkowski, M., Banerjee, S. R., Pomper, M. G., Bruchertseifer, F., Morgenstern, A., & Sofou, S. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0207 · Cited by 35
Radchenko, V., Mastren, T., Meyer, C. A. L., Ivanov, A. S., Bryantsev, V. S., Copping, R., Denton, D., Engle, J. W., Griswold, J. R., Murphy, K., et al. (2017) · Talanta · doi:10.1016/j.talanta.2017.07.057 · Cited by 30
Self-citationChouin, N., Lindegren, S., Jensen, H., Albertsson, P., & Bäck, T. A. (2012) · PubMed · Cited by 14
Research works printed but not linked: 5
- [26]Dilling J. Kreuken R. Merminga L. ISAC and ARIEL: The TRIUMF Radioactive Beam Facilities and the Scientific Program. Springer 2014
- [35]Stacey M.W. Nuclear Reactor Physics. 2nd ed Weinheim, Germany Wiley-VCH 2007
- [41]Lesrel J. Arianer J. Arianer M. Bajeat O. Buhour J-m. Byzl H. Carrey F. Chabot M. Corbin T. Croizet H. Curaudeau J. Doizon F. Ducourtieu M. Dufour J-m. Grialou D. Joly C. Kaminski M. Lefort H. Lesellier B. Magneney G. Mottet L. Planat C. Raynaud M. Richard Y. Said A. Semsoum A. Taquin F. Vogel C. Bienvenu G. Cayla J-n. Lal M.D. Commissioning of the Alto 50 MeV Electron Linac. Proc. EPAC 2006 2006 3 5
- [47]Jost C.U. Griswold J.R. Bruffey S.H. Mirzadeh S. Stracener D.W. Williams C.L. Measurement of cross sections for the 232Th(P,4n) 229Pa reaction at low proton energies. AIP Conf. Proc. 2013 1525 520 524
- [71]Merminga L. Ames F. Baartman R. Bricault P. Bylinski Y. Chao Y.C. Dawson R. Kaltchev D. Koscielniak S. Laxdal R. Mammarella F. Marchetto M. Minor G. Mitra A. Rao Y.N. Trinczek M. Trudel A. Verzilov V. Zvyagintsev V. ariel: triumf’s advanced rare isotope laboratory. Proceedings of 2011 IPAC2011 1917 1919
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Background
Metadata
- Authors
- Robertson, A. K. H., Ramogida, C. F., Schaffer, P., & Radchenko, V.
- Affiliations
- TRIUMF (CA)
- Corresponding author
- Radchenko, Valery
- Venue
- Current Radiopharmaceuticals
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2018-10-22
- Volume
- 11
- Issue
- 3
- Pages
- 156-172
- ISSN
- 1874-4710 (ISSN-L)
- PMC
- PMC6249690
- OpenAlex
- W2801430183
- Cited by
- 202
- References
- 59
- Citations by year
- 2026: 23 · 2025: 35 · 2024: 34 · 2023: 24 · 2022: 22 · 2021: 29 · 2020: 26 · 2019: 8 · 2018: 1
- FWCI
- 11.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc
- Locations
- Current Radiopharmaceuticals (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Chemical Reactions and Isotopes
- Physical Sciences › Physics and Astronomy › Radiation › Radioactivity and Radon Measurements
- Keywords
- actinium-225, radiopharmaceuticals, targeted alpha therapy, TRIUMF, isotope separation, radiolabeling yield, alpha-emitting radionuclides
- MeSH terms
- Actinium, Alpha Particles, Humans, Neoplasms, Radiochemistry, Radionuclide Generators, Radiopharmaceuticals
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