Cited by 105Alcohol Consumption and Health EffectsNeurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

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Putative Role of Brain Acetaldehyde in Ethanol Addiction

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Deng, Xin-sheng, Deitrich, Richard·2008·Current Drug Abuse Reviewse

DOI 10.2174/1874473710801010003PMC PMC2613359

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Abstract

The putative contribution of brain acetaldehyde (AcH) to ethanol (EtOH) tolerance and dependence (addiction) is reviewed. Although the role of AcH in EtOH addiction has been controversial, there are data showing a relationship. AcH can be formed in the brain tissues through the peroxidatic activity of catalase and by oxidation via other oxidizing enzymes such as cytochrome P-4502E1. Significant formation of AcH occurs in vitro in brain tissue at concentrations of EtOH that can be achieved by voluntary consumption of EtOH by rodents. AcH itself possesses reinforcing properties, which suggests that some of the behavioral pharmacological effects attributed to EtOH may be a result of the formation of AcH, and supports the involvement of AcH in EtOH addiction. Modulation of aldehyde dehydrogenase (ALDH) and brain catalase activity can change EtOH-related addictive behaviors presumably by changing AcH levels. Moreover, some condensation reaction products of AcH may promote some actions of EtOH and its consumption. On the basis of the findings, it can be concluded that AcH may mediate some of the CNS actions of EtOH including tolerance and dependence, although further exploration the involvement of AcH in EtOH addiction is warranted.

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Authors: Deng, X.-S., & Deitrich, R.
Affiliations: University of Colorado Health (US)
ORCID: Deng, Xin-sheng
Venue: Current Drug Abuse Reviewse
Publisher: Bentham Science Publishers Ltd.
Published: 2008-01-01
Volume: 1
Issue: 1
Pages: 3-8
ISSN: 1874-4737 (ISSN-L)
DOI: 10.2174/1874473710801010003
PMC: PMC2613359
OpenAlex: W2007321017
Cited by: 105
References: 72
Citations by year: 2026: 3 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 5 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 9 · 2014: 7 · 2013: 15 · 2012: 14
FWCI: 4.49
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Current Drug Abuse Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (AA011464, R01AA011464)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: acetaldehyde, ethanol addiction, ethanol tolerance, ethanol dependence, catalase, CYP2E1, aldehyde dehydrogenase, ethanol reinforcement
MeSH terms: Aldehyde Dehydrogenase, Mitochondrial, Acetaldehyde, Ethanol, Alcoholism, Aldehyde Dehydrogenase, Animals, Brain, Catalase, Drug Tolerance, Humans, Motivation, Rodentia, Cytochrome P-450 CYP2E1

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Putative Role of Brain Acetaldehyde in Ethanol Addiction

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