Alcohol Abuse, Immunosuppression, and Pulmonary Infection

Nelson, Steve; Zhang, Ping; Bagby, Gregory; Happel, Kyle; Raasch, Caroline

doi:10.2174/1874473710801010056

Cited by 107Alcohol Consumption and Health EffectsPneumonia and Respiratory InfectionsSubstance Abuse Treatment and Outcomes

Alcohol Abuse, Immunosuppression, and Pulmonary Infection

Nelson, Steve, Zhang, Ping, Bagby, Gregory, Happel, Kyle, Raasch, Caroline·2008·Current Drug Abuse Reviewse

DOI 10.2174/1874473710801010056

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Abstract

Excessive alcohol consumption predisposes the host to a wide range of infectious complications, particularly pulmonary infections. Factors that contribute to the development of pulmonary infections in alcohol-abusing patients include dysfunction of the protective barriers in the respiratory tract, aspiration of oropharyngeal contents, nutritional deficiencies, liver disease, and impairment of host defense mechanisms. This review discusses the complex host-pathogen interactions in the airways with an emphasis on how alcohol consumption adversely affects these mechanisms and predisposes the host to infections. Potential immunomodulatory strategies for enhancing host defense function in alcohol-consuming patients are also discussed.

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Alcohol exposure impairs the functioning of phagocytes such as polymorphonuclear leucocytes (especially neutrophils) and macrophages.
“Alcohol exposure impairs the functioning of phagocytes such as polymorphonuclear leucocytes (especially neutrophils) and macrophages 79.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [79]
Chronic alcohol exposure specifically impairs the immune defences and functioning of the lower respiratory tract, increasing the risk of both viral and bacterial pneumonia.
“Apart from the general immunosuppressive effects explained above, chronic alcohol exposure specifically impairs the immune defences and functioning of the lower respiratory tract, increasing the risk of both viral and bacterial pneumonia.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [79]
Most mental disorders, including major depressive disorders, have consistent associations with alcohol use, especially with heavy drinking and alcohol use disorders.
“Most mental disorders, including major depressive disorders, have consistent associations with alcohol use, and especially with heavy drinking and alcohol use disorders 79, 80, 81, 214, 215, 216, 217.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [79]

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The Granulocyte Colony‐Stimulating Factor Response after Intrapulmonary and Systemic Bacterial Challenges
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A Time-Dependent Analysis of Intensive Care Unit Pneumonia in Trauma Patients
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Clinically Relevant Concentrations of Ethanol Attenuate Primed Neutrophil Bactericidal Activity
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Escherichia coli pneumonia enhances granulopoiesis and the mobilization of myeloid progenitor cells into the systemic circulation
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Ethanol Impairs Certain Aspects of Neutrophil Adhesion In Vitro: Comparisons with Inhibition of Expression of the CD18 Antigen
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Alcohol Decreases T‐Lymphocyte Migration into Lung Tissue in Response to Pneumocystis carinii and Depletes T‐Lymphocyte Numbers in the Spleens of Mice
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Ethanol Suppression of the Functional State of Polymorphonuclear Leukocytes Obtained From Uninfected and Simian Immunodeficiency Virus Infected Rhesus Macaques
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Neutrophil Modulation of the Pulmonary Chemokine Response to Lipopolysaccharide
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GM-CSF therapy and capillary-leak syndrome
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Autopsy case of alcoholic hepatitis and cirrhosis treated with corticosteroids and affected by Pneumocystis carinii and cytomegalovirus pneumonia
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Alcohol Intoxication Inhibits Pulmonary S100A8 and S100A9 Expression in Rats Challenged With Intratracheal Lipopolysaccharide
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The relationship between different dimensions of alcohol use and the burden of disease—an update
Rehm, J., Gmel, G. E., Gmel, G., Hasan, O. S. M., Imtiaz, S., Popova, S., Probst, C., Roerecke, M., Room, R., Samokhvalov, A. V., et al. (2017) · Addiction · doi:10.1111/add.13757 · Cited by 1,204 · see citing works
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COVID-19 and Substance Use Disorders as Brain Diseases: Recommendations to a Comprehensive Healthcare Response. An International Society of Addiction Medicine (ISAM) Practice and Policy Interest Group Position Paper
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Neutropenia during HIV Infection: Adverse Consequences and Remedies
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Influence of alcoholism and cholesterol on TSPO binding in brain: PET [11C]PBR28 studies in humans and rodents
Kim, S. W., Wiers, C. E., Tyler, R., Kojori, E. S., Jang, Y. J., Zehra, A., Freeman, C. R., Ramirez, V., Lindgren, E., Miller, G., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0085-x · Cited by 73 · see citing works
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Epigenetic targets for reversing immune defects caused by alcohol exposure
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Poor Clinical Outcomes Among Pneumonia Patients With Schizophrenia
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M2b Macrophage Elimination and Improved Resistance of Mice with Chronic Alcohol Consumption to Opportunistic Infections
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Intrapulmonary G-CSF Rescues Neutrophil Recruitment to the Lung and Neutrophil Release to Blood in Gram-Negative Bacterial Infection in MCP-1−/− Mice
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Whipple Disease a Century After the Initial Description
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Risk factors associated with acute exacerbation of chronic obstructive pulmonary disease in HIV-infected and uninfected patients
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Mechanisms by Which Chronic Ethanol Feeding Limits the Ability of Dendritic Cells to Stimulate T-Cell Proliferation
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Alcohol abuse and disorder of granulopoiesis
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Acute Alcohol Intoxication Impairs the Hematopoietic Precursor Cell Response to Pneumococcal Pneumonia
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Understanding gender inequities in antimicrobial resistance: role of biology, behaviour and gender norms
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Ethanol metabolism, oxidative stress, and endoplasmic reticulum stress responses in the lungs of hepatic alcohol dehydrogenase deficient deer mice after chronic ethanol feeding
Kaphalia, L., Boroumand, N., Ju, H., Kaphalia, B. S., & Calhoun, W. J. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.02.018 · Cited by 28 · see citing works
Chronic alcohol increases CD8+ T-cell immunosenescence in simian immunodeficiency virus-infected rhesus macaques
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Authors: Nelson, S., Zhang, P., Bagby, G., Happel, K., & Raasch, C.
Affiliations: Louisiana State University Health Sciences Center New Orleans (US)
ORCID: Nelson, Steve
Zhang, Ping
Venue: Current Drug Abuse Reviewse
Publisher: Bentham Science Publishers Ltd.
Published: 2008-01-01
Volume: 1
Issue: 1
Pages: 56-67
ISSN: 1874-4737 (ISSN-L)
DOI: 10.2174/1874473710801010056
OpenAlex: W2149505706
Cited by: 107
References: 133
Citations by year: 2026: 4 · 2025: 11 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 12 · 2016: 6 · 2015: 9 · 2014: 6 · 2013: 4 · 2012: 11
FWCI: 2.37
Type: journal article
Language: en
Open access: closed
Locations: Current Drug Abuse Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (AA09803)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: alcohol abuse, immunosuppression, pulmonary infection, aspiration, nutritional deficiency, liver disease, host-pathogen interaction
MeSH terms: Alcoholism, Animals, Anti-Bacterial Agents, Humans, Immune Tolerance, Immunity, Active, Immunity, Cellular, Immunity, Innate, Immunologic Factors, Opportunistic Infections, Pneumonia, Pneumocystis, Risk Factors, Cytokines, Immunocompromised Host, Pneumonia, Bacterial, Pneumocystis carinii, Mice, Rats

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Alcohol Abuse, Immunosuppression, and Pulmonary Infection

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