The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Telomere Length Variations in Aging and Age-Related Diseases
Abstract
Telomeres are gene sequences present at chromosomal ends and are responsible for maintaining genome integrity. Telomere length is maximum at birth and decreases progressively with advancing age and thus is considered as a biomarker of chronological aging. This age associated decrease in the length of telomere is linked to various ageing associated diseases like diabetes, hypertension, Alzheimer's disease, cancer etc. and their associated complications. Telomere length is a result of combined effect of oxidative stress, inflammation and repeated cell replication on it, and thus forming an association between telomere length and chronological aging and related diseases. Thus, decrease in telomere length was found to be important in determining both, the variations in longevity and age-related diseases in an individual. Ongoing and progressive research in the field of telomere length dynamics has proved that aging and age-related diseases apart from having a synergistic effect on telomere length were also found to effect telomere length independently also. Here a short description about telomere length variations and its association with human aging and age-related diseases is reviewed.
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Cites
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Healthcare on the brink: navigating the challenges of an aging society in the United States
Jones, C. H., & Dolsten, M. (2024) · npj Aging · doi:10.1038/s41514-024-00148-2 · Cited by 363
The integration of inflammaging in age-related diseases
Fulop, T., Witkowski, J. M., Olivieri, F., & Larbi, A. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.09.003 · Cited by 348
Effect of resveratrol and pterostilbene on aging and longevity
Li, Y., Li, S., & Lin, C. (2018) · BioFactors · doi:10.1002/biof.1400 · Cited by 346
Dynamic DNA methylation during aging: A "prophet" of age-related outcomes
Xiao, F.-H., Wang, H.-T., & Kong, Q.-P. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00107 · Cited by 140
Gatto, N., Dos Santos Souza, C., Shaw, A. C., Bell, S. M., Myszczynska, M. A., Powers, S., Meyer, K., Castelli, L. M., Karyka, E., Mortiboys, H., et al. (2021) · Aging Cell · doi:10.1111/acel.13281 · Cited by 58
Metadata
- Authors
- Rizvi, S., Raza, S. T., & Mahdi, F.
- Venue
- Current Aging Science
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2015-03-02
- Volume
- 7
- Issue
- 3
- Pages
- 161-167
- ISSN
- 1874-6098 (ISSN-L)
- OpenAlex
- W2168718017
- Cited by
- 207
- References
- 15
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rizvi, S., Raza, S. T., & Mahdi, F. (2015). Telomere Length Variations in Aging and Age-Related Diseases. Current Aging Science. https://doi.org/10.2174/1874609808666150122153151
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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