The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
Skeletal Muscle Protein Balance and Metabolism in the Elderly
Open accessAbstract
The loss of lean muscle mass occurring with advancing age is termed sarcopenia. This condition often leads to a concomitant loss of strength, increased frailty and risk of falls and an overall loss of functional independence in the elderly. Muscle protein metabolism is a dynamic process characterized by the balance between the synthesis and breakdown of muscle proteins. A disturbance of this equilibrium can lead to the loss of muscle mass, and a perturbation of muscle protein turnover with aging has been proposed to play a role in the development of sarcopenia. However, basal muscle protein synthesis and breakdown rates do not differ between young and old adults, which has led to the hypothesis that older adults are resistant to anabolic stimuli. In support of this hypothesis, older adults have either no response or a blunted response to nutrients, insulin and resistance exercise, and this anabolic resistance is likely a key factor in the loss of skeletal muscle mass with aging. Recent studies have investigated potential interventions to overcome this anabolic resistance. In particular, combining resistance exercise with essential amino acid supplementation restores the muscle protein anabolic response in older men. The novel rehabilitation technique of performing light resistance exercise during blood flow restriction was also successful in overcoming the anabolic resistance to exercise. Future research is needed to determine whether these novel interventions will be successful in preventing sarcopenia and improving muscle strength and function in older adults.
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“contemporary human biopsy data confirm that the primary defect resides deep within the structural architecture of the muscle fiber [102,103].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [103]
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Regulation of antioxidant defenses in the prevention of skeletal muscle deconditioning
Arc‐Chagnaud, C. (2019) · theses.fr (ABES) · doi:10.70675/5f87ccb5z5cb5z4962zb4c3z4133c1b52a4b
Metadata
- Authors
- S. Fry, C., & B. Rasmussen, B.
- Venue
- Current Aging Sciencee
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2011-12-01
- Volume
- 4
- Issue
- 3
- Pages
- 260-268
- ISSN
- 1874-6098 (ISSN-L)
- PMC
- PMC5096733
- OpenAlex
- W2042172969
- Cited by
- 111
- References
- 136
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 11 · 2023: 11 · 2022: 12 · 2021: 13 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 8 · 2014: 3 · 2013: 3 · 2012: 8
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Aging Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000071)
- National Institute on Aging (P30AG024832)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR049877)
- National Center for Research Resources (UL1RR029876)
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32-HD-07539, T32HD007539)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- sarcopenia, muscle protein balance, muscle protein synthesis, muscle protein degradation, anabolic resistance, aging, resistance training, essential amino acid supplementation, blood flow restriction, frailty, muscle strength, older adults
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Amino Acids, Female, Humans, Male, Middle Aged, Muscle Contraction, Muscle Proteins, Nutritional Status, Muscle, Skeletal, Dietary Supplements, Resistance Training, Sarcopenia
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