Follow-up strategies for primary extremity soft-tissue sarcoma in adults: A systematic review of the published literature
Open accessAbstract
AIM: Follow-up strategies for primary extremity soft-tissue sarcomas (eSTS) in adults were evaluated in a systematic review of the published literature. MATERIAL AND METHODS: The published literature was reviewed using PubMed. Of 136,646 studies published between 1985 and 2019, 78 original articles met the inclusion criteria. Articles were selected on the basis of the PRISMA guidelines. The selected articles were then cross-searched to identify further publications. August 1, 2019 was used as the concluding date of publication. RESULTS: A variety of follow-up schedules have been reported in recently published literature. Two official guidelines have been approved by international societies. The guidelines distinguish between high- and low-grade STS, but mention a wide range of follow-up intervals. Established tools of follow-up include computed tomograph, X-rays of the chest, and magnetic resonance imaging of the primary tumor site in addition to clinical observation and physical examination. CONCLUSION: Further research will be needed to establish evidence-based guidelines and schedules for follow-up strategies in patients with eSTS.
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Imaging and clinicopathologic assessment mainly capture anatomic disease rather than real-time molecular activity.
“however, they mainly capture anatomic disease rather than real-time molecular activity [ 6 , 7 , 8 ].”
From Signals Alongside Scans: A Genomics-Guided Framework for Liquid Biopsy in Bone and Soft-Tissue Sarcomas (2026) · cites this paper as [8]
Current sarcoma surveillance remains centered on imaging and clinicopathologic assessment.
“Current sarcoma surveillance remains centered on imaging and clinicopathologic assessment.”
From Signals Alongside Scans: A Genomics-Guided Framework for Liquid Biopsy in Bone and Soft-Tissue Sarcomas (2026) · cites this paper as [8]
In postoperative and post-treatment settings, radiologic interpretation may be complicated by fibrosis, necrosis, inflammation, postsurgical change, and stable residual abnormalities that do not reliably distinguish treatment effect from viable disease.
“In the postoperative and post-treatment setting, radiologic interpretation may be further complicated by fibrosis, necrosis, inflammation, postsurgical change, and stable residual abnormalities that do not reliably distinguish treatment effect from viable disease [ 6 , 7 , 8 ].”
From Signals Alongside Scans: A Genomics-Guided Framework for Liquid Biopsy in Bone and Soft-Tissue Sarcomas (2026) · cites this paper as [8]
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Flagged first, then by citations
Research works printed but not linked: 4
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Cited by
Sorted by citations
Alabid, I., Yousef, A. J., Patni, M. M., Aloti, R. A., Qassim, Z. A.-A. M., Alothman-Agha, A. A., Hamdy, H. A., Noury, F. M., & Abdelfattah, M. T. (2026) · Cells · doi:10.3390/cells15141271
- Authors
- DAMMERER, D., VAN BEECK, A., SCHNEEWEISS, V., & SCHWABEGGER, A.
- Affiliations
- Innsbruck Medical University (AT)
- Venue
- In Vivo
- Published
- 2020
- Volume
- 34
- Issue
- 6
- Pages
- 3057-3068
- ISSN
- 0258-851X (ISSN-L)
- 1791-7549
- PMC
- PMC7811670
- OpenAlex
- W3095538791
- Cited by
- 14
- References
- 103
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2022: 2 · 2021: 2 · 2020: 1
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- In Vivo (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac tumors and thrombi
- Health Sciences › Medicine › Rheumatology › Soft tissue tumor case studies
- Keywords
- extremity soft tissue sarcoma, follow-up strategy, surveillance interval, recurrence detection, high-grade sarcoma, low-grade sarcoma, computed tomography, chest radiography, magnetic resonance imaging, clinical observation, physical examination
- MeSH terms
- Adult, Bone Neoplasms, Extremities, Follow-Up Studies, Humans, Sarcoma, Soft Tissue Neoplasms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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