Cited by 271Artificial Intelligence in Healthcare and EducationInnovations in Medical EducationArtificial Intelligence in Education

Performance of GPT-3.5 and GPT-4 on the Japanese Medical Licensing Examination: Comparison Study

Open access
Takagi, Soshi, Watari, Takashi, Erabi, Ayano, Sakaguchi, Kota·2023·JMIR Medical Education

Published version of a preprint

Abstract

Background: The competence of ChatGPT (Chat Generative Pre-Trained Transformer) in non-English languages is not well studied. Objective: This study compared the performances of GPT-3.5 (Generative Pre-trained Transformer) and GPT-4 on the Japanese Medical Licensing Examination (JMLE) to evaluate the reliability of these models for clinical reasoning and medical knowledge in non-English languages. Methods: This study used the default mode of ChatGPT, which is based on GPT-3.5; the GPT-4 model of ChatGPT Plus; and the 117th JMLE in 2023. A total of 254 questions were included in the final analysis, which were categorized into 3 types, namely general, clinical, and clinical sentence questions. Results: The results indicated that GPT-4 outperformed GPT-3.5 in terms of accuracy, particularly for general, clinical, and clinical sentence questions. GPT-4 also performed better on difficult questions and specific disease questions. Furthermore, GPT-4 achieved the passing criteria for the JMLE, indicating its reliability for clinical reasoning and medical knowledge in non-English languages. Conclusions: GPT-4 could become a valuable tool for medical education and clinical support in non–English-speaking regions, such as Japan.

AI snapshot

Written from the paper’s full text.

TL;DR

GPT-4 outperformed GPT-3.5 on the 117th Japanese Medical Licensing Examination (JMLE), reaching the authors’ stated passing criteria while GPT-3.5 did not. The study suggests GPT-4 has improved non-English medical knowledge and clinical reasoning, though limitations include a March 2023 snapshot and exclusion of image/table questions.

Key findings

  • Overall, GPT-4 answered 79.9% (95% CI 75.0-84.9) of the 254 analyzed JMLE questions correctly versus 50.8% (95% CI 44.6-57.0) for GPT-3.5, a 29.1% improvement (P<.001).
  • By question category, GPT-4 scored 87.2% on essential knowledge, 73.3% on general clinical, and 81.7% on specific disease questions; GPT-3.5 scored 55.1%, 43.8%, and 56.3%, respectively (all P<.001).
  • By question type, GPT-4 scored 79.1% on general, 79.6% on clinical, and 86.3% on clinical sentence questions, compared with approximately 50% for GPT-3.5 across these types (all P<.05).
  • By difficulty, GPT-4 scored 87.8% on easy, 77.7% on normal, and 73.3% on hard questions; GPT-3.5 scored 69.5%, 46.2%, and 33.3%, respectively. For hard questions, GPT-4’s rate was 17% higher than the examinees’ average correct response rate.

Methods

  • The study used the 117th JMLE from 2023, with 254 questions included after excluding 5 officially excluded questions and questions containing tables (n=7), images (n=125), or underlining (n=9).
  • GPT-3.5 (default ChatGPT) and GPT-4 (ChatGPT Plus) were queried in Japanese with original JMLE questions and multiple-choice answers; responses were collected between March 16 and 18, 2023.
  • Questions were categorized by type (general, clinical, clinical sentence) and difficulty (easy, normal, hard) based on medu4 correct-response rates; correct-response rates were compared using the McNemar test in Stata, with 2-tailed significance at P<.05.

Limitations

  • The paper states that results reflect ChatGPT capabilities as of March 17 and 18, 2023, and may change as models improve.
  • The paper states that image and table questions were excluded to allow accurate comparison with GPT-3.5, and that the JMLE supplementary assessment for absolute contraindication answers was not evaluated because failed applicants’ scores were not published.
  • The paper states that only ChatGPT was investigated, not other LLMs such as Bard or LLaMA; evident from the text, the clinical sentence question subset was small (n=22) with wide confidence intervals, and the difficulty-level counts differ between the Methods text and Table 3.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.2196/48002

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

0 of 11 cited sources checked · 0 supported · 0 flagged

  • Findingown data

    GPT-4 achieved a 27.6% increase over GPT-3.5 in correct response rate for general questions (P<.001).

    “However, GPT-4 achieved a 27.6% increase for general questions (P<.001) and a 29.6% increase for clinical questions (P<.001) compared to GPT-3.5.”
    Quote in the paperSubstantial claim
  • Findingown data

    GPT-4 achieved a 29.6% increase over GPT-3.5 in correct response rate for clinical questions (P<.001).

    “However, GPT-4 achieved a 27.6% increase for general questions (P<.001) and a 29.6% increase for clinical questions (P<.001) compared to GPT-3.5.”
    Quote in the paperSubstantial claim
  • Findingown data

    GPT-4 achieved a 31.5% increase over GPT-3.5 in correct response rate for normal-level questions (P<.001).

    “However, GPT-4 exhibited improved performance, with a 40% increase for hard-level questions (P<.001), a 31.5% increase for normal-level questions (P<.001), and an 18.3% increase for easy-level questions (P<.001).”
    Quote in the paperSubstantial claim
  • Findingown data

    GPT-4 achieved a 40% increase over GPT-3.5 in correct response rate for hard-level questions (P<.001).

    “However, GPT-4 exhibited improved performance, with a 40% increase for hard-level questions (P<.001), a 31.5% increase for normal-level questions (P<.001), and an 18.3% increase for easy-level questions (P<.001).”
    Quote in the paperSubstantial claim
  • Findingown data

    None of GPT-4's correct response rates on the 117th JMLE exceeded the total percentage of correct answers by examinees.

    “However, none of these rates exceeded the total percentage of correct answers by examinees.”
    Quote in the paperNot a substantial claim
  • May combine two claims. 6
  • The quote only partly states this claim. 1
  • Classified as probably not a substantial claim. 7
  • May combine two claims.

    Findingown data

    GPT-4 achieved an 87.2% correct response rate on essential knowledge questions of the 117th JMLE, a 32.1% improvement over GPT-3.5's 55.1%.

    “In terms of the correct response rate for individual questions, the examinees’ rate for essential knowledge questions was 89.2% compared to 87.2% for GPT-4. Notably, this represents a considerable 32.1% improvement over GPT-3.5, which had a 55.1% correct response rate.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    GPT-3.5 achieved a 69.5% correct response rate for easy-level questions, 46.2% for normal-level questions, and 33.3% for hard-level questions on the 117th JMLE.

    “GPT-3.5 only achieved a 69.5% correct response rate for easy-level questions, 46.2% for normal-level questions, and 33.3% for hard-level questions.”
    Quote in the paperSubstantial claim
  • The quote only partly states this claim.

    Findingown data

    GPT-4 achieved the JMLE passing rates in all question categories (essential knowledge, general clinical, and specific disease).

    “In all cases, GPT-4 achieved the passing rates for the JMLE.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    GPT-3.5 achieved correct response rates of approximately 50% across question types on the 117th JMLE, none of which are passing scores.

    “Table 2 presents the correct response rates according to the question type, with GPT-3.5 achieving correct response rates of approximately 50%—none of which are passing scores.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    GPT-4 passed the 117th JMLE, whereas GPT-3.5 failed the examination.

    “GPT-4 passed the 117th JMLE, whereas GPT-3.5 failed the examination.”
    • Also stated in: § Principal Findings · plain
      “GPT-3.5 did not satisfy the passing criteria, whereas GPT-4 achieved the required scores.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    ChatGPT achieved the passing criteria for the US Medical Licensing Examination.

    “In the medical domain, ChatGPT achieved the passing criteria for the US Medical Licensing Examination (USMLE) [5,6].”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [5] source

      Not checked in the free run.

    • cites [6] source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Even in English, in a real clinical setting, GPT-3.5 cannot answer questions at a level acceptable to fully qualified primary care physicians.

    “A previous study suggests that even in English, in a real clinical setting, GPT-3.5 cannot answer questions at a level acceptable to fully qualified primary care physicians [10].”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [10] source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    Compared with GPT-3.5, GPT-4 is more reliable, creative, and able to handle many more nuanced instructions.

    “Compared with its predecessor GPT-3.5, GPT-4 is “more reliable, creative, and able to handle many more nuanced instructions” [12].”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [12] GPT-4 is OpenAI’s most advanced system, producing safer and more useful responsesOpenAI2023-03-19https://openai.com/product/gpt-4

      Not checked in the free run.

  • Classified as probably not a substantial claim. May combine two claims.

    Study design and conductreasoning

    Questions announced as excluded by the MHLW and questions containing tables, images, or underlining were excluded from the analysis, leaving 254 questions.

    “The exclusion criteria included questions for which the Ministry of Health, Labour and Welfare (MHLW) announced as being excluded (n=5), as well as questions containing tables (n=7), images (n=125), and underlining (n=9), which are not recognized by ChatGPT. In total, 254 questions were used in the final analysis.”
    Quote in the paperSubstantial claim
  • Classified as probably not a substantial claim.

    Premisecitation

    ChatGPT based on GPT-3.5 performed poorly for 77 out of 79 medical students on a South Korean parasitology examination.

    “However, in a previous study, ChatGPT, based on GPT-3.5 (Generative Pre-trained Transformer), performed poorly for 77 out of 79 medical students on a South Korean parasitology examination, which resulted in questions about its ability to provide medically accurate responses in non-English languages [11].”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [11] source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S2 (checkable).

    Interpretationreasoning

    GPT-4 could become a valuable tool for medical education and clinical support in non-English-speaking regions such as Japan.

    “GPT-4 could become a valuable tool for medical education and clinical support in non–English-speaking regions, such as Japan.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    OpenAI reported that hallucinations have been mitigated in GPT-4 compared with GPT-3.5.

    “OpenAI reported that hallucinations have been mitigated in GPT-4 compared with GPT-3.5 [21].”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [21] GPT-4 system cardOpenAI20233232023-03-21https://cdn.openai.com/papers/gpt-4-system-card.pdf

      Not checked in the free run.

12 of 12
  • The paper relies on this without support.

    The Japanese Medical Licensing Examination is a valid benchmark for clinical reasoning and medical knowledge in Japanese.

    “The JMLE is a mandatory exam for certifying medical practitioners in Japan, necessitating a comprehensive knowledge base and strong clinical reasoning skills.”
  • The paper relies on this without support.

    The 254 included questions are representative of the full 117th JMLE for comparing GPT-3.5 and GPT-4.

    “In total, 254 questions were used in the final analysis.”
2 of 2

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

  • Easy and hard question counts are reversed

    Minor

    The Methods report 82 hard and 60 easy questions, but Table 3 reports 60 hard and 82 easy questions.

  • Difficulty thresholds differ at their boundaries

    Minor

    The Methods include a 79.9% response rate in the hard category and a 97% rate in the easy category. Table 3's note uses strict inequalities that exclude both boundary values.

  • Difficulty-group GPT-3.5 rates do not match the overall rate

    Minor

    Weighting Table 3's GPT-3.5 rates by its question counts gives approximately 50.7%, not the 50.8% reported for all 254 questions in Table 1; the gap exceeds rounding to one decimal place. The normal-group rate of 46.2% also cannot result from an integer number correct out of 112 questions.

3 of 3

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. 2021, Stata 17 Base Reference Manual
  2. 10.48550/arXiv.2305.13102 · DOI

Cited by

Sorted by citations

Authors
Takagi, S., Watari, T., Erabi, A., & Sakaguchi, K.
Affiliations
  • Shimane University (JP)
  • Shimane University Hospital (JP)
Corresponding author
Watari, Takashi
Venue
JMIR Medical Education
Published
2023-06-29
Volume
9
Pages
e48002
ISSN
2369-3762 (ISSN-L)
OpenAlex
W4380685958
Cited by
271
References
25
Citations by year
2026: 27 · 2025: 87 · 2024: 125 · 2023: 31 · 2022: 1
FWCI
10.78
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • JMIR Medical Education (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Shimane University
Topics
  • Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Innovations in Medical Education
  • Physical Sciences › Computer Science › Information Systems › Artificial Intelligence in Education
Keywords
GPT-3.5, GPT-4, large language models, clinical reasoning, medical knowledge, model comparison, medical licensing examinations, medical education

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