Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis
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Abstract
BACKGROUND: Acetyl hexapeptide-8, also known as Argireline, is a topical, short-acting, synthetic peptide that has recently gained popularity for its antiwrinkle effects. This agent has emerged as a more accessible alternative to botulinum neurotoxin. OBJECTIVE: This study evaluates the public interest in acetyl hexapeptide-8 in the United States from 2013 to 2023, as described by search volume on Google, the most-used search engine. METHODS: We analyzed the longitudinal relative monthly search volume from January 1, 2013, to January 1, 2023, for acetyl hexapeptide-related terms. We compared the internet search trends for "Botox" during this period to "Argireline." RESULTS: The terms "Argireline" and "Botox in a Bottle" both had substantial increases in search volume in 2022. Although its search volume is drastically increasing, "Argireline" was less searched than "Botox," which had a stable, up-trending search volume over the past decade. CONCLUSIONS: The increasing interest in acetyl hexapeptide-8 may be due to its cost-effectiveness and use as a botulinum neurotoxin alternative. Affordability, over-the-counter availability, and ease of self-application of the agent suggest its potential to enhance accessibility to cosmetic dermatologic care.
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Acetyl hexapeptide-8 has anti-wrinkle effects.
“Acetyl hexapeptide-8, a synthetic peptide derived from the N-terminus of synaptosomal-associated protein of 25 kDa (SNAP-25), has anti-wrinkle effects, which makes it a safe and more accessible alternative to botulinum neurotoxin [33].”
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Cited by
Sorted by citations
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- Authors
- Olsson, S. E., Sreepad, B., Lee, T., Fasih, M., & Fijany, A.
- Corresponding author
- Olsson, Sofia Eva
- Venue
- JMIR Dermatology
- Publisher
- JMIR Publications Inc.
- Published
- 2024-02-20
- Volume
- 7
- Pages
- e54217
- ISSN
- 2562-0959 (ISSN-L)
- PMC
- PMC10915729
- OpenAlex
- W4391291409
- Cited by
- 11
- References
- 19
- Citations by year
- 2026: 5 · 2025: 6
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- JMIR Dermatology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Social Sciences › Health › Social Media in Health Education
- Health Sciences › Medicine › Neurology › Botulinum Toxin and Related Neurological Disorders
- Keywords
- onabotulinumtoxinA, internet search trends, public interest, cosmetic dermatology, cost-effectiveness
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