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Cited by 69Facial Rejuvenation and Surgery TechniquesSkin Protection and AgingDermatologic Treatments and Research

The Anti-Wrinkle Efficacy of Argireline, a Synthetic Hexapeptide, in Chinese Subjects: A Randomized, Placebo-Controlled Study

Wang, Yuan, Wang, Mei, Xiao, Shengxiang, Pan, Ping, Li, Ping, Huo, Jia·2013·American Journal of Clinical Dermatology
DOI 10.1007/s40257-013-0009-9
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Abstract

Background Argireline is a synthetic peptide that is patterned from the N-terminal end of the protein SNAP-25 and has been shown to reduce the degree of facial wrinkles. It is reported to inhibit vesicle docking by preventing formation of the ternary SNARE complex and by interfering in catecholamine release. The anti-wrinkle efficacy of argireline has not been studied in Chinese subjects.Objective The objective of the study was to evaluate the safety and efficacy of argireline in the treatment of peri-orbital wrinkles in Chinese subjects.Methods A total of 60 subjects received a randomized treatment of argireline or placebo in a ratio of 3:1. Argireline or placebo was applied to their peri-orbital wrinkles twice daily for 4 weeks, and then evaluations were made for the improvements in wrinkles. In the subjective evaluation, Daniell's classification and Seeman's standard were applied to make a global assessment of changes in the appearance of peri-orbital lines. In the objective evaluation, silicone replicas of the skin at the application area were made before and after the treatment, which were analyzed by a wrinkle-analysis apparatus.Results In the subjective evaluation, the total anti-wrinkle efficacy in the argireline group was 48.9 %, compared with 0 % in the placebo group. In the objective evaluation, the parameters of roughness were all decreased in the argireline group (p < 0.01), while no decrease was obvious in the placebo group (p > 0.05).Conclusions This study showed that argireline had a significant anti-wrinkle effect in Chinese subjects.

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Crossref · 10.1007/s40257-013-0009-9

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  • Wang et al.'s study did not provide information on potential confounding variables such as age, gender, or skin type.

    “Additionally, the study did not provide information on potential confounding variables, such as age, gender, or skin type, which could impact the efficacy of Argireline.”

    From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [57]

  • Wang et al.'s randomized, placebo-controlled study found that Argireline significantly improved wrinkle depth and skin roughness compared with placebo in Chinese subjects.

    “The randomized, placebo‐controlled study found that participants who used Argireline showed significant improvement in wrinkle depth and skin roughness compared to those who used a placebo.”

    From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [57]

  • Wang et al.'s study had a small sample size of 60 participants, which may limit generalizability.

    “First, the sample size was relatively small, with only 60 participants included in the study. This small sample size may limit the generalizability of the results to a larger population.”

    From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [57]

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Authors
Wang, Y., Wang, M., Xiao, S., Pan, P., Li, P., & Huo, J.
Affiliations
Second Affiliated Hospital of Xi'an Jiaotong University (CN)
Corresponding author
Wang, Mei
ORCID
Venue
American Journal of Clinical Dermatology
Publisher
Springer Science and Business Media LLC
Published
2013-02-16
Volume
14
Issue
2
Pages
147-153
ISSN
  • 1175-0561 (ISSN-L)
  • 1179-1888
DOI
10.1007/s40257-013-0009-9
OpenAlex
W1551045385
Cited by
69
References
133
Citations by year
2026: 10 · 2025: 11 · 2024: 8 · 2023: 10 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 3 · 2016: 1
FWCI
0.39
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • American Journal of Clinical Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords
hexapeptide, facial wrinkles, skin roughness, silicone replicas, Chinese subjects
MeSH terms
Administration, Topical, Adult, China, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Esthetics, Female, Follow-Up Studies, Humans, Male, Middle Aged, Oligopeptides, Prospective Studies, Skin Aging, Treatment Outcome, Patient Satisfaction

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