Effect of turmeric extract on bone healing in an experimental model of femoral bone fracture
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Objective: molecules. Materials and Methods: Eight rats were subjected to surgery, randomly divided into two groups, and treated orally with turmeric (200 mg/kg), or olive oil. Four oil-treated rats without bone fracture were used as control group. After six weeks of treatment, the femurs of animals were examined for radiological, histological, and gene expression analysis. Results: ratio (p=0.01) in femoral bone tissue. Conclusion: Our findings indicated the turmeric ability to facilitate bone hemostasis and optimize the expression of key markers involved in the bone metabolism.
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For irisin, tumeric acid, aqueous extract of Prunus dulcis, and the Chinese herbal formula 'Zhèng Gŭ Zĭ Jīn Dān', acceleration of fracture healing has not yet been shown in clinical studies with patients and appropriate study design.
“Aditionally, irisin (119), tumeric acid (120), aqueous extract of Prunus dulcis (121), and the Chinese acupuncture and herbal formula powder prescription ‘Zhèng Gŭ Zĭ Jīn Dān’ (122) are thought to accelerate fracture healing, but this has not yet been shown in clinical studies with patients and with an appropriate study design.”
From Methods to accelerate fracture healing – a narrative review from a clinical perspective (2024) · cites this paper as [120]
The Materials and Methods and Results describe improved fracture healing after turmeric extract treatment in Wistar rats, supporting the suggestion of a potential benefit. The paper does not establish whether appropriately designed clinical studies in patients have shown such a benefit; it also does not address the other substances named in the sentence. This verdict concerns only the turmeric citation. (LLM, conf=0.84)
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Methods to accelerate fracture healing – a narrative review from a clinical perspective
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- Authors
- Ilka
- Venue
- PubMed
- Publisher
- National Institutes of Health
- Published
- 2022-01-01
- Volume
- 12
- Issue
- 3
- Pages
- 197-212
- PMC
- PMC9482714
- OpenAlex
- W3193783563
- Cited by
- 7
- References
- 47
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Medicinal Plant Pharmacodynamics Research
- Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
- Keywords
- turmeric extract, bone regeneration, femoral fracture, bone fractures, bone metabolism, gene expression, bone histology, bone radiology, olive oil placebo, rats
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