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Cited by 305Adrenal and Paraganglionic TumorsAdrenal Hormones and DisordersMedical Imaging Techniques and Applications

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Delayed Enhanced CT of Lipid-Poor Adrenal Adenomas

Caoili, Elaine M., Korobkin, Melvyn, Francis, Isaac R., Cohan, Richard H., Dunnick, N. Reed·2000·American Journal of Roentgenology
DOI 10.2214/ajr.175.5.1751411
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Abstract

OBJECTIVE: Although representing a minority of adrenal adenomas, the lipid-poor variety cannot be accurately identified on unenhanced CT or chemical shift MR imaging. We compared the delayed contrast-enhanced CT features of lipid-poor adenomas with those of lipid-rich adenomas and of adrenal nonadenomas to determine whether there were differences in the washout features between these groups of lesions. SUBJECTS AND METHODS: Eighteen proven lipid-poor adenomas, 56 lipid-rich adenomas, and 40 adrenal nonadenomas underwent CT before, immediately after, and 15 min delay after IV contrast injection. Region-of-interest measurements were made of all adrenal lesions at the three time points. The degree of enhancement, enhancement washout, percentage enhancement washout, and relative percentage enhancement washout were calculated for each adrenal mass. Pooled data were analyzed statistically. Optimal threshold values for diagnosing adrenal adenomas were also determined. RESULTS: The mean CT attenuation of lipid-poor adenomas was significantly higher than that of lipid-rich adenomas at all three phases but not significantly different from that of nonadenomas. The mean percentage enhancement washout on images obtained 15 min after administration of contrast material was similar for lipid-rich and lipid-poor adenomas but was significantly higher than that of nonadenomas. The mean relative percentage enhancement washout was significantly different among all three groups. CONCLUSION: Lipid-poor adenomas cannot be differentiated from adrenal nonadenomas on the basis of a single mean attenuation value. However, lipid-poor adrenal adenomas show enhancement and enhancement washout features nearly identical to lipid-rich adenomas and can be distinguished from nonadenomas on the basis of a percentage washout threshold value of 60% and a relative percentage washout of 40%.

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Crossref · 10.2214/ajr.175.5.1751411

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Metadata

Authors
Caoili, E. M., Korobkin, M., Francis, I. R., Cohan, R. H., & Dunnick, N. R.
Affiliations
University of Michigan (US)
ORCID
Venue
American Journal of Roentgenology
Publisher
American Roentgen Ray Society
Published
2000-11
Volume
175
Issue
5
Pages
1411-1415
ISSN
  • 0002-9580 (ISSN-L)
  • 0361-803X
  • 1546-3141
DOI
10.2214/ajr.175.5.1751411
OpenAlex
W1992652357
Cited by
305
References
13
Citations by year
2026: 3 · 2025: 8 · 2024: 10 · 2023: 9 · 2022: 17 · 2021: 18 · 2020: 12 · 2019: 7 · 2018: 17 · 2017: 13 · 2016: 11 · 2015: 14 · 2014: 20 · 2013: 24 · 2012: 10
FWCI
5.33
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Roentgenology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords
adrenal adenoma, CT attenuation
MeSH terms
Adenoma, Adrenal Gland Neoplasms, Adult, Aged, Aged, 80 and over, Contrast Media, Diatrizoate, Female, Follow-Up Studies, Humans, Injections, Intravenous, Lipids, Male, Middle Aged, Radiographic Image Enhancement, Sensitivity and Specificity, Time Factors, Tomography, X-Ray Computed

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