CT time-attenuation washout curves of adrenal adenomas and nonadenomas

Korobkin, M; Brodeur, F J; Francis, I R; Quint, L E; Dunnick, N R; Londy, F

doi:10.2214/ajr.170.3.9490968

Cited by 387Adrenal and Paraganglionic TumorsMedical Imaging Techniques and ApplicationsAdrenal Hormones and Disorders

CT time-attenuation washout curves of adrenal adenomas and nonadenomas

Korobkin, M, Brodeur, F J, Francis, I R, Quint, L E, Dunnick, N R, Londy, F·1998·American Journal of Roentgenology

DOI 10.2214/ajr.170.3.9490968

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Abstract

OBJECTIVE: The purpose of this study was to analyze the CT contrast enhancement washout curves of adrenal masses and to determine the earliest time after initial enhancement that differentiation of adenomas from nonadenomas is possible. MATERIALS AND METHODS: Contrast enhancement washout curves were generated after delayed contrast-enhanced CT scans of 52 adrenal adenomas and 24 nonadenomas. The optimal threshold value and corresponding sensitivity and specificity for the diagnosis of adenoma were determined according to attenuation values. Also, we calculated the percentage and relative percentage of enhancement washout at time delays from 5 to 45 min after initial enhancement. RESULTS: The mean percentage of enhancement washout for adrenal adenomas was 51% at 5 min and 70% at 15 min, compared with 8% and 20%, respectively, for nonadenomas. The sensitivity and specificity for the diagnosis of adenoma were both 96% at a threshold attenuation value of 37 H on the 15-min delayed enhanced scan. CONCLUSION: On CT, adrenal adenomas show a much earlier and more rapid washout of contrast enhancement than do nonadenomas. Adenomas and nonadenomas can be differentiated by attenuation values or the percentage or relative percentage of washout as early as 5-15 min after enhancement.

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Relative washout >40% suggests benign adenoma.
“Values of > 40% suggest a benign adenoma (296,299,300) (Fig. 6).”
From Adrenal incidentaloma (2020) · cites this paper as [300]

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Authors: Korobkin, M., Brodeur, F. J., Francis, I. R., Quint, L. E., Dunnick, N. R., & Londy, F.
Affiliations: University of Michigan (US)
ORCID: Francis, I R
Quint, L E
Dunnick, N R
Venue: American Journal of Roentgenology
Publisher: American Roentgen Ray Society
Published: 1998-03
Volume: 170
Issue: 3
Pages: 747-752
ISSN: 0002-9580 (ISSN-L)
0361-803X
1546-3141
DOI: 10.2214/ajr.170.3.9490968
OpenAlex: W2105886595
Cited by: 386
References: 8
Citations by year: 2026: 3 · 2025: 9 · 2024: 10 · 2023: 10 · 2022: 9 · 2021: 17 · 2020: 12 · 2019: 6 · 2018: 14 · 2017: 17 · 2016: 14 · 2015: 20 · 2014: 22 · 2013: 22 · 2012: 12
FWCI: 7.03
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Roentgenology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: adrenal adenoma, adrenal mass, time-attenuation curves, sensitivity and specificity
MeSH terms: Adenoma, Adrenal Gland Neoplasms, Adult, Aged, Aged, 80 and over, Contrast Media, Diagnosis, Differential, Female, Humans, Male, Middle Aged, ROC Curve, Sensitivity and Specificity, Tomography, X-Ray Computed

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CT time-attenuation washout curves of adrenal adenomas and nonadenomas

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