Prevalence and Correlates of Cognitive Impairment in Hemodialysis Patients: The Frequent Hemodialysis Network Trials
Open accessAbstract
BACKGROUND AND OBJECTIVES: Cognitive impairment is common among persons with ESRD, but the underlying mechanisms are unknown. This study evaluated the prevalence of cognitive impairment and association with modifiable ESRD- and dialysis-associated factors in a large group of hemodialysis patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Cross-sectional analyses were conducted on baseline data collected from 383 subjects participating in the Frequent Hemodialysis Network trials. Global cognitive impairment was defined as a score <80 on the Modified Mini-Mental State Exam, and impaired executive function was defined as a score >or=300 seconds on the Trailmaking B test. Five main categories of explanatory variables were examined: urea clearance, nutritional markers, hemodynamic measures, anemia, and central nervous system (CNS)-active medications. RESULTS: Subjects had a mean age of 51.6 +/- 13.3 years and a median ESRD vintage of 2.6 years. Sixty-one subjects (16%) had global cognitive impairment, and 110 subjects (29%) had impaired executive function. In addition to several nonmodifiable factors, the use of H1-receptor antagonists and opioids were associated with impaired executive function. No strong association was found between several other potentially modifiable factors associated with ESRD and dialysis therapy, such as urea clearance, proxies of dietary protein intake and other nutritional markers, hemodynamic measures, and anemia with global cognition and executive function after adjustment for case-mix factors. CONCLUSIONS: Cognitive impairment, especially impaired executive function, is common among hemodialysis patients, but with the exception of CNS-active medications, is not strongly associated with several ESRD- and dialysis-associated factors.
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The prevalence of cognitive impairment in hemodialysis patients is approximately 70-80%, significantly higher than in individuals with normal kidney function.
“Previous studies including our own indicated that the prevalence of CI was ranged from 70 to 80%, which was significantly higher than those individuals with normal kidney function (Kurella Tamura et al., 2010; O’Lone et al., 2016; van Zwieten et al., 2018; Luo et al., 2020).”
From Association Between Sleep Disorders and Cognitive Impairment in Middle Age and Older Adult Hemodialysis Patients: A Cross-Sectional Study (2021) · cites this paper as Kurella Tamura et al., 2010
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Cites
Statistical Analysis With Missing Data
Lahiff, M., Little, R. J. A., & Rubin, D. B. (1989) · Journal of the American Statistical Association · doi:10.2307/2289883 · Cited by 17,384 · see citing works
(1987) · PubMed · Cited by 2,657 · see citing works
Hachinski, V., Iadecola, C., Petersen, R. C., Breteler, M. M., Nyenhuis, D. L., Black, S. E., Powers, W. J., DeCarli, C., Merino, J. G., Kalaria, R. N., et al. (2006) · Stroke · doi:10.1161/01.str.0000237236.88823.47 · Cited by 1,722 · see citing works
Fried, L. P. (1998) · JAMA · doi:10.1001/jama.279.8.585 · Cited by 1,107 · see citing works
Cognitive impairment in hemodialysis patients is common
Murray, A. M., Tupper, D. E., Knopman, D. S., Gilbertson, D. T., Pederson, S. L., Li, S., Smith, G. E., Hochhalter, A. K., Collins, A. J., & Kane, R. L. (2006) · Neurology · doi:10.1212/01.wnl.0000225182.15532.40 · Cited by 712 · see citing works
Adapting the charlson comorbidity index for use in patients with ESRD
Hemmelgarn, B. R., Manns, B., Quan, H., & Ghali, W. A. (2003) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(03)00415-3 · Cited by 496 · see citing works
Cognitive Impairment in Chronic Kidney Disease
Tamura, M. K., Chertow, G. M., Luan, J., & Yaffe, K. S. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52508.x · Cited by 474 · see citing works
Self-citationJohnson, J. K., Lui, L.-Y., & Yaffe, K. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.10.1134 · Cited by 339 · see citing works
Systemic markers of inflammation and cognitive decline in old age
Schram, M. T., Euser, S. M., De Craen, A. J. M., Witteman, J. C., Frölich, M., Hofman, A., Jolles, J., Breteler, M. M. B., & Westendorp, R. G. J. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01159.x · Cited by 326 · see citing works
Validation of 2 Depression Screening Tools in Dialysis Patients
Watnick, S. G., Wang, P.-L., Demadura, T. L., & Ganzini, L. K. (2005) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.08.006 · Cited by 324 · see citing works
Prevalence, recognition, and implications of mental impairment among hemodialysis patients
Sehgal, A. R., Grey, S. F., DeOreo, P. B., & Whitehouse, P. J. (1997) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(97)90563-1 · Cited by 274 · see citing works
The Beck Depression Inventory as a Screening Device for Major Depression in Renal Dialysis Patients
Craven, J. L., Rodin, G., & Littlefield, C. H. (1989) · The International Journal of Psychiatry in Medicine · doi:10.2190/m1tx-v1ej-e43l-rklf · Cited by 257 · see citing works
Tamura, M. K., Mapes, D., Port, F. K., & Chertow, G. M. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl275 · Cited by 243 · see citing works
Self-citationrHuEPO treatment improves brain and cognitive function of anemic dialysis patients
Marsh, J. T., Brown, W. S., Wolcott, D. L., Carr, C. R., Harper, R., Schweitzer, S., & Nissenson, A. R. (1991) · Kidney International · doi:10.1038/ki.1991.20 · Cited by 233 · see citing works
Self-citationFrequent Hemodialysis Network (FHN) randomized trials: study design.
Suri, R. S., Garg, A. X., Chertow, G. M., Levin, N. W., Rocco, M. V., Greene, T., Beck, G., Gassman, J., Eggers, P. W., Star, R. A., et al. (2007) · Kidney International · doi:10.1038/sj.ki.5002032 · Cited by 193 · see citing works
Self-citationEffects of hemodialysis dose and membrane flux on health-related quality of life in the HEMO Study
Unruh, M. L., Benz, R. L., Greene, T., Yan, G., Beddhu, S., Devita, M., Dwyer, J. T., Kimmel, P. L., Kusek, J. W., Martin, A., et al. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00738.x · Cited by 180 · see citing works
Self-citationCerebrovascular Effects of Hemodialysis in Chronic Kidney Disease
Prohovnik, I., Post, J. B., Uribarri, J., Lee, H., Sandu, O. A., & Langhoff, E. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600478 · Cited by 175 · see citing works
Cognitive functioning pre- to post-kidney transplantation--a prospective study
Griva, K., Thompson, D., Jayasena, D., Davenport, A., Harrison, M. J., & Newman, S. P. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl385 · Cited by 159 · see citing works
Clinical Features of Pruritus Among Patients Undergoing Maintenance Hemodialysis
Gilchrest, B. A. (1982) · Archives of Dermatology · doi:10.1001/archderm.1982.01650150016012 · Cited by 140 · see citing works
Bioimpedance norms for the hemodialysis population
Chertow, G. M., Lazarus, J. M., Lew, N. L., Ma, L., & Lowrie, E. G. (1997) · Kidney International · doi:10.1038/ki.1997.493 · Cited by 137 · see citing works
Self-citationBeneficial effect of renal transplantation on cognitive brain function
Kramer, L., Madl, C., Stockenhuber, F., Yeganehfar, W., Eisenhuber, E., Derfler, K., Lenz, K., Schneider, B., & Grimm, G. (1996) · Kidney International · doi:10.1038/ki.1996.115 · Cited by 132 · see citing works
Murray, A. M., Pederson, S. L., Tupper, D. E., Hochhalter, A. K., Miller, W. A., Li, Q., Zaun, D. A., Collins, A. J., Kane, R. L., & Foley, R. N. (2007) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2007.05.010 · Cited by 129 · see citing works
Statistical Analysis with Missing Data
Richards, L. E., Little, R. J. A., & Rubin, D. B. (1989) · Journal of Marketing Research · doi:10.2307/3172915 · Cited by 125 · see citing works
Silent Cerebral Infarction in Hemodialysis Patients
Nakatani, T., Naganuma, T., Uchida, J., Masuda, C., Wada, S., Sugimura, T., & Sugimura, K. (2003) · American Journal of Nephrology · doi:10.1159/000068034 · Cited by 120 · see citing works
Mizumasa, T., Hirakata, H., Yoshimitsu, T., Hirakata, E., Kubo, M., Kashiwagi, M., Tanaka, H., Kanai, H., Fujimi, S., & Iida, M. (2004) · Nephron Clinical Practice · doi:10.1159/000077592 · Cited by 116 · see citing works
Jassal, S. V., Devins, G. M., Chan, C. T., Bozanovic, R., & Rourke, S. B. (2006) · Kidney International · doi:10.1038/sj.ki.5001691 · Cited by 90 · see citing works
Subcortical cognitive impairment in dialysis patients
Pereira, A. A., Weiner, D. E., Scott, T. M., Chandra, P., BLUESTEIN, R., Griffith, J. L., & Sarnak, M. J. (2007) · Hemodialysis International · doi:10.1111/j.1542-4758.2007.00185.x · Cited by 87 · see citing works
Homocysteine Lowering and Cognition in CKD: The Veterans Affairs Homocysteine Study
Brady, C. B., Gaziano, J. M., Cxypoliski, R. A., Guarino, P., Kaufman, J. S., Warren, S. R., Hartigan, P. M., Goldfarb, D. S., & Jamison, R. L. (2009) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2009.05.013 · Cited by 75 · see citing works
Silent cerebral infarction predicts vascular events in hemodialysis patients
Naganuma, T., Uchida, J., Tsuchida, K., Takemoto, Y., Tatsumi, S., Sugimura, K., & Nakatani, T. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00351.x · Cited by 72 · see citing works
Teschan, P. E., Bourne, J. R., Rb, R., & Jw, W. (1983) · PubMed · Cited by 46 · see citing works
Solute Clearances and Fluid Removal in the Frequent Hemodialysis Network Trials
Greene, T., Daugirdas, J. T., Depner, T. A., Gotch, F. A., & Kuhlman, M. (2009) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2008.12.039 · Cited by 45 · see citing works
Schwartz, I. F., & Iaina, A. (2000) · Seminars in Dialysis · doi:10.1046/j.1525-139x.2000.00050.x · Cited by 19 · see citing works
Physiological responses of type A and type B men during cognitive performance
Pishkin, V., Braggio, J. T., & Lovallo, W. R. (1987) · Journal of Clinical Psychology · doi:10.1002/1097-4679(198705)43:3 · Cited by 9 · see citing works
Flagged first, then by citations
1 of the 34 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [21]Yeudall LT, Reddon JR, Gill DM, Stefanyk WO: Normative data for the Halstead-Reitan neuropsychological tests stratified by age and sex. J Clin Psychol 43: 346–367, 1987 [DOI] [PubMed] [Google Scholar]
Cited by
Sorted by citations
Histamine and H1-antihistamines: Celebrating a century of progress
Simons, F. E. R., & Simons, K. J. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.09.005 · Cited by 541 · see citing works
Cognitive Impairment in CKD: Pathophysiology, Management, and Prevention
Drew, D. A., Weiner, D. E., & Sarnak, M. J. (2019) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2019.05.017 · Cited by 459 · see citing works
Dementia and cognitive impairment in ESRD: diagnostic and therapeutic strategies
Tamura, M. K., & Yaffe, K. S. (2010) · Kidney International · doi:10.1038/ki.2010.336 · Cited by 337 · see citing works
Self-citationFrequency of and risk factors for poor cognitive performance in hemodialysis patients
Sarnak, M. J., Tighiouart, H., Scott, T. M., Lou, K. V., Sorensen, E. P., Giang, L. M., Drew, D. A., Shaffi, S. K., Strom, J. A., Singh, A. K., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e31827f0f7f · Cited by 258 · see citing works
Relationship between Hypotension and Cerebral Ischemia during Hemodialysis
MacEwen, C., Sutherland, S., Daly, J., Pugh, C. W., & Tarassenko, L. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016060704 · Cited by 192 · see citing works
Cardiovascular Disease and Cognitive Function in Maintenance Hemodialysis Patients
Weiner, D. E., Scott, T. M., Giang, L. M., Agganis, B. T., Sorensen, E. P., Tighiouart, H., & Sarnak, M. J. (2011) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2011.03.034 · Cited by 115 · see citing works
Tamura, M. K., Unruh, M. L., Nissenson, A. R., Larive, B., Eggers, P. W., Gassman, J., Mehta, R. L., Kliger, A. S., & Stokes, J. B. (2012) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2012.09.009 · Cited by 112 · see citing works
Self-citationRenal Replacement Therapy in the Elderly Population
Berger, J. R., & Hedayati, S. S. (2012) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.10411011 · Cited by 112 · see citing works
Neumann, D., Mau, W., Wienke, A., & Girndt, M. (2017) · Kidney International · doi:10.1016/j.kint.2017.07.022 · Cited by 101 · see citing works
Cognitive function and advanced kidney disease: longitudinal trends and impact on decision-making
Iyasere, O. U., Okai, D., & Brown, E. A. (2016) · Clinical Kidney Journal · doi:10.1093/ckj/sfw128 · Cited by 95 · see citing works
van Zwieten, A., Wong, G., Ruospo, M., Palmer, S. C., Barulli, M. R., Iurillo, A., Saglimbene, V., Natale, P., Gargano, L., Murgo, M., et al. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfx314 · Cited by 93 · see citing works
Chu, N. M., Hong, J., Harasemiw, O., Chen, X., Fowler, K. J., Dasgupta, I., Bohm, C. J., Segev, D. L., McAdams‐DeMarco, M., & the Global Renal Exercise Network (2021) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfab338 · Cited by 90 · see citing works
Rosner, M. H., Husain‐Syed, F., Reis, T. D. A., Ronco, C., & Vanholder, R. C. (2021) · Kidney International · doi:10.1016/j.kint.2021.09.025 · Cited by 90 · see citing works
Epidemiology of chronic kidney disease among older adults: a focus on the oldest old.
Bowling, C., & Muntner, P. (2012) · The journals of gerontology. Series A, Biological sciences and medical sciences · doi:10.1093/gerona/gls173 · Cited by 83 · see citing works
Hudson, J. L., Moss-Morris, R. E., Norton, S., Picariello, F., Game, D. S., Carroll, A., Spencer, J., McCrone, P., Hotopf, M. H., Yardley, L., et al. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.09.009 · Cited by 86 · see citing works
Cognitive disorders in patients with chronic kidney disease: specificities of clinical assessment
Pépin, M., Ferreira, A. C., Arıcı, M., Bachman, M., Barbieri, M., Bumblytė, I. A., Carriazo, S. M., Delgado, P., Gârneaţă, L., Giannakou, K., et al. (2021) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfab262 · Cited by 78 · see citing works
Cognitive Impairment in CKD: No Longer an Occult Burden
Murray, A. M., & Knopman, D. S. (2010) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2010.08.003 · Cited by 77 · see citing works
Anemia and risk for cognitive decline in chronic kidney disease
Tamura, M. K., Vittinghoff, E., Yang, J., Go, A. S., Seliger, S. L., Kusek, J. W., Lash, J. P., Cohen, D. L., Simon, J. F., Batuman, V., et al. (2016) · BMC Nephrology · doi:10.1186/s12882-016-0226-6 · Cited by 77 · see citing works
Self-citationβ2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function
Gao, Y., Hong, Y., Huang, L., Zheng, S., Zhang, H., Wang, S., Yao, Y., Zhao, Y., Zhu, L., Xu, Q., et al. (2023) · Cell · doi:10.1016/j.cell.2023.01.021 · Cited by 75 · see citing works
Kidney Transplantation Improves Cognitive and Psychomotor Functions in Adult Hemodialysis Patients
Radić, J., Ljutić, D., Radić, M., Kovačić, V., Dodig‐Ćurković, K., & Šain, M. (2011) · American Journal of Nephrology · doi:10.1159/000330849 · Cited by 74 · see citing works
Cassidy, B. P., Getchell, L. E., Harwood, L., Hemmett, J., & MOIST, L. M. (2018) · Canadian Journal of Kidney Health and Disease · doi:10.1177/2054358118803322 · Cited by 75 · see citing works
Dementia and Alzheimer's Disease among Older Kidney Transplant Recipients
McAdams‐DeMarco, M., Bae, S., Chu, N. M., Gross, A. L., Brown, C. H., Oh, E. S., Rosenberg, P. B., Neufeld, K. J., Varadhan, R., Albert, M., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016080816 · Cited by 68 · see citing works
Clinical Predictors of Individual Cognitive Fluctuations in Patients Undergoing Hemodialysis
Costa, A. S., Tiffin-Richards, F. E., Holschbach, B., Frank, R. D., Vassiliadou, A., Krüger, T., Eitner, F., Gross, T., Shah, N. J., Schulz, J. B., et al. (2014) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2014.02.012 · Cited by 69 · see citing works
Intradialytic Cognitive and Exercise Training May Preserve Cognitive Function
McAdams‐DeMarco, M., Konel, J. M., Warsame, F., Ying, H., González‐Fernández, M., Carlson, M. C., Fine, D. M., Appel, L. J., & Segev, D. L. (2017) · Kidney International Reports · doi:10.1016/j.ekir.2017.08.006 · Cited by 70 · see citing works
Cognitive Changes in Chronic Kidney Disease and After Transplantation
van Sandwijk, M. S., ten Berge, I. J. M., Majoie, C. B. L. M., Caan, M. W. A., de Sonneville, L. M. J., van Gool, W. A., & Bemelman, F. J. (2015) · Transplantation · doi:10.1097/tp.0000000000000968 · Cited by 65 · see citing works
Sorensen, E. P., Sarnak, M. J., Tighiouart, H., Scott, T. M., Giang, L. M., Kirkpatrick, B., Lou, K. V., & Weiner, D. E. (2012) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2011.12.029 · Cited by 63 · see citing works
Consequences of CKD on Functioning
Kittiskulnam, P., Sheshadri, A., & Johansen, K. L. (2016) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2016.05.007 · Cited by 63 · see citing works
Harhay, M. N., Xie, D., Zhang, X., Hsu, C., Vittinghoff, E., Go, A. S., Sozio, S. M., Blumenthal, J. B., Seliger, S. L., Chen, J., et al. (2018) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2018.02.361 · Cited by 61 · see citing works
Self-citationTian, X., Guo, X., Xia, X., Yu, H., Li, X., & Jiang, A. (2019) · Medicine · doi:10.1097/md.0000000000014390 · Cited by 63 · see citing works
FGF ‐23 and cognitive performance in hemodialysis patients
Drew, D. A., Tighiouart, H., Scott, T. M., Lou, K. V., Fan, L., Shaffi, S. K., Weiner, D. E., & Sarnak, M. J. (2013) · Hemodialysis International · doi:10.1111/hdi.12100 · Cited by 57 · see citing works
Cognitive Function and Dialysis Adequacy: No Clear Relationship
Giang, L. M., Weiner, D. E., Agganis, B. T., Scott, T. M., Sorensen, E. P., Tighiouart, H., & Sarnak, M. J. (2010) · American Journal of Nephrology · doi:10.1159/000322611 · Cited by 56 · see citing works
Zhang, J., Wu, L., Wang, P., Pan, Y., Dong, X., Jia, L., & Zhang, A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0304762 · Cited by 62 · see citing works
Cognitive Changes in Peritoneal Dialysis Patients: A Multicenter Prospective Cohort Study
Zhang, Y., Yang, Z., Wang, J., Xiong, Z., Liao, J., Li, H., Liu, G., Ren, Y., Wang, Q., Duan, L.-P., et al. (2018) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2018.04.020 · Cited by 49 · see citing works
Functional Disability in Older Adults Maintained on Peritoneal Dialysis Therapy
Ulutaş, Ö., Farragher, J. F., Chiu, E., Cook, W. L., & Jassal, S. V. (2014) · Peritoneal Dialysis International · doi:10.3747/pdi.2013.00293 · Cited by 48 · see citing works
O’Hare, A. M., Walker, R. L., Haneuse, S., Crane, P. K., McCormick, W. C., Bowen, J. D., & Larson, E. B. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.04238.x · Cited by 48 · see citing works
Olczyk, P., Kusztal, M. A., Gołębiowski, T., Letachowicz, K., & Krajewska, M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19042389 · Cited by 45 · see citing works
Robinski, M., Mau, W., Wienke, A., & Girndt, M. (2016) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv464 · Cited by 45 · see citing works
Cognitive Impairment is Associated with Mortality in Hemodialysis Patients
Angermann, S., Schier, J., Baumann, M., Steubl, D., Hauser, C., Lorenz, G., Günthner, R., Braunisch, M. C., Kemmner, S., Satanovskij, R. M., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180767 · Cited by 47 · see citing works
Luo, Y., Murray, A. M., Guo, Y., Tian, R., Ye, P., Li, X., Li, G.-G., Lu, F., Ma, Y., Sun, Y., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-69482-1 · Cited by 44 · see citing works
Schneider, S. M., Kielstein, J. T., Braverman, J. A., & Novák, M. (2015) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2015.06.002 · Cited by 43 · see citing works
Rehabilitation of the Geriatric Dialysis Patient
Farragher, J. F., & Jassal, S. V. (2012) · Seminars in Dialysis · doi:10.1111/sdi.12014 · Cited by 42 · see citing works
Screening of Cognitive Impairment in the Dialysis Population: A Scoping Review
San, A., Hiremagalur, B., Muircroft, W., & Grealish, L. A. (2017) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000479679 · Cited by 41 · see citing works
Cognitive function among hemodialysis patients in Japan
小田桐, 元., Sugawara, N., Kikuchi, A., Takahashi, I., Umeda, T., Saitoh, H., Yasui‐Furukori, N., & Kaneko, S. (2011) · Annals of General Psychiatry · doi:10.1186/1744-859x-10-20 · Cited by 42 · see citing works
Post, J. B., Morin, K. G., Sano, M. C., Jegede, A. B., Langhoff, E., & Spungen, A. M. (2011) · American Journal of Nephrology · doi:10.1159/000334871 · Cited by 41 · see citing works
Barrantes, F., Luan, F. L., Kommareddi, M., Alazem, K., Yaqub, T. M., Roth, R. S., Sung, R. S., Cibrik, D. M., Song, P. X. ‐., & Samaniego, M. (2013) · Kidney International · doi:10.1038/ki.2013.136 · Cited by 41 · see citing works
Koncicki, H. M., & Schell, J. O. (2015) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2015.09.032 · Cited by 41 · see citing works
Association of Sleep-Disordered Breathing With Cognitive Dysfunction in CKD Stages 4-5
Kang, E. W., Abdel-Kader, K. F. M., Yabes, J. G., Glover, K., & Unruh, M. L. (2012) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2012.08.033 · Cited by 39 · see citing works
Self-citationCognitive Impairment in Dialysis Patients: Focus on the Blood Vessels?
Seliger, S. L., & Weiner, D. E. (2013) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2012.12.002 · Cited by 37 · see citing works
Angermann, S., Baumann, M., Steubl, D., Lorenz, G., Hauser, C., Suttmann, Y., Reichelt, A.-L., Satanovskij, R. M., Sonntag, F., Heemann, U. W., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184589 · Cited by 38 · see citing works
Exercise and cognitive function in patients with end‐stage kidney disease
Chu, N. M., & McAdams‐DeMarco, M. (2019) · Seminars in Dialysis · doi:10.1111/sdi.12804 · Cited by 36 · see citing works
Chu, N. M., Shi, Z., Haugen, C. E., Norman, S. P., Gross, A. L., Brennan, D. C., Carlson, M. C., Segev, D. L., & McAdams‐DeMarco, M. (2020) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2019.10.014 · Cited by 36 · see citing works
study, T. F., Dixon, B. S., VanBuren, J. M., Rodrigue, J. R., Lockridge, R. S., Lindsay, R. M., Chan, C. T., Rocco, M. V., Oleson, J., Beglinger, L. J., et al. (2016) · BMC Nephrology · doi:10.1186/s12882-016-0223-9 · Cited by 36 · see citing works
Self-citation“Is It Removed During Dialysis?”—Cognitive Dysfunction in Advanced Kidney Failure—A Review Article
Crowe, K., Quinn, T. J., Mark, P. B., & Findlay, M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.787370 · Cited by 36 · see citing works
Dasgupta, I., Patel, M., Mohammed, N. I., Baharani, J., Subramanian, T., Thomas, G. N., & Tadros, G. (2018) · Blood Purification · doi:10.1159/000485961 · Cited by 35 · see citing works
Scale development study: The F luid C ontrol in H emodialysis P atients
Çoşar, A. A., & PAKYÜZ, S. Ç. (2015) · Japan Journal of Nursing Science · doi:10.1111/jjns.12083 · Cited by 33 · see citing works
Decision-Making in Geriatric Patients with End-Stage Renal Disease: Thinking Beyond Nephrology
Ahmed, F. A., & Catic, A. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm8010005 · Cited by 33 · see citing works
Ali, H., Soliman, K., Mohamed, M., Daoud, A., Shafiq, T., Fülöp, T., & Baharani, J. (2020) · International Urology and Nephrology · doi:10.1007/s11255-020-02603-x · Cited by 33 · see citing works
Foote, C., Morton, R. L., Jardine, M., Gallagher, M., Brown, M. A., Howard, K., & Cass, A. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu257 · Cited by 31 · see citing works
Variability of Cognitive Performance during Hemodialysis: Standardization of Cognitive Assessment
Tholen, S., Schmaderer, C., Kusmenkov, E., Chmielewski, S., Förstl, H., Kehl, V., Heemann, U. W., Baumann, M., & Grimmer, T. (2014) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000357803 · Cited by 32 · see citing works
Zhang, J., Tang, L., Hu, J., Wang, Y., & Xu, Y. (2020) · Brain and Behavior · doi:10.1002/brb3.1542 · Cited by 31 · see citing works
Feasibility Trial of Cognitive Behavioral Therapy for Fatigue in Hemodialysis (BReF Intervention)
Picariello, F., Moss-Morris, R. E., Norton, S., Macdougall, I. C., Silva‐Gane, M. D., Farrington, K., Clayton, H., & Chilcot, J. (2020) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2020.10.005 · Cited by 30 · see citing works
Interventions for fatigue in people with kidney failure requiring dialysis
Natale, P., Ju, A., Strippoli, G. F., Craig, J. C., Saglimbene, V. M., Unruh, M. L., Stallone, G., & Jauré, A. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013074.pub2 · Cited by 31 · see citing works
Self-citationNervous system disorders in dialysis patients
Bansal, V., & Bansal, S. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-7020-4086-3.00025-4 · Cited by 31 · see citing works
Liu, G., Pi, H.-C., Hao, L., Li, D., Wu, Y., & Dong, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143782 · Cited by 30 · see citing works
Geriatric Renal Palliative Care
Swidler, M. A. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls202 · Cited by 28 · see citing works
Patient‐reported cognitive functioning and daily functioning in chronic dialysis patients
Song, M., Ward, S. E., Bair, E., Weiner, L. J., Bridgman, J. C., Hladik, G. A., & Gilet, C. A. (2014) · Hemodialysis International · doi:10.1111/hdi.12202 · Cited by 27 · see citing works
SHARMA, A. K., Yabes, J. G., Mawed, S. A., Wu, C. M., Stilley, C. S., Unruh, M. L., & Jhamb, M. (2016) · American Journal of Nephrology · doi:10.1159/000451059 · Cited by 27 · see citing works
Self-citationLambourg, E. J., Colvin, L., Guthrie, G. D., Walker, H., & Bell, S. (2021) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.08.035 · Cited by 26 · see citing works
Delirium, changes in cognitive function, and risk of diagnosed dementia after kidney transplantation
Chu, N. M., Bae, S., Chen, X., Ruck, J. M., Gross, A. L., Albert, M., Neufeld, K. J., Segev, D. L., & McAdams‐DeMarco, M. (2022) · American Journal of Transplantation · doi:10.1111/ajt.17176 · Cited by 26 · see citing works
Cognitive Impairment and its Correlates in Chronic Kidney Disease Patients Undergoing Haemodialysis
Joseph, S. J., Bhandarı, S. S., & Dutta, S. (2019) · Journal of Evolution of Medical and Dental Sciences · doi:10.14260/jemds/2019/611 · Cited by 26 · see citing works
Cao, T., An, R., Wang, Y., Lei, J., Liang, J., & Wan, Q. (2023) · Journal of Advanced Nursing · doi:10.1111/jan.15746 · Cited by 24 · see citing works
Nutrition Assessment and Risk Prediction in Dialysis Patients—A New Integrative Score
Benyamini, S. B., Katzir, Z., Biro, A., Cernes, R., Shalev, B., Chaimy, T., & Barnea, Z. (2014) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2014.05.001 · Cited by 24 · see citing works
Home versus in-centre haemodialysis for end-stage kidney disease
Palmer, S. C., Palmer, A. R., Craig, J. C., Johnson, D. W., Stroumza, P., Frantzen, L., Leal, M. R., Hoischen, S., Hegbrant, J., & Strippoli, G. F. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009535.pub2 · Cited by 24 · see citing works
Role of Vitamin D in Cognitive Function in Chronic Kidney Disease
Cheng, Z., Lin, J., & Qian, Q. (2016) · Nutrients · doi:10.3390/nu8050291 · Cited by 23 · see citing works
Schmaderer, C., Tholen, S., Hasenau, A.-L., Hauser, C., Suttmann, Y., Wassertheurer, S., Mayer, C. C., Bauer, A., Rizas, K. D., Kemmner, S., et al. (2016) · BMC Nephrology · doi:10.1186/s12882-016-0374-8 · Cited by 24 · see citing works
Breaking the cycle of functional decline in older dialysis patients
Hall, R. K., & McAdams‐DeMarco, M. (2018) · Seminars in Dialysis · doi:10.1111/sdi.12695 · Cited by 23 · see citing works
Iyasere, O. U., & Brown, E. A. (2017) · Kidney International · doi:10.1016/j.kint.2017.01.022 · Cited by 22 · see citing works
Reduction of Amyloid-β Plasma Levels by Hemodialysis: An Anti-Amyloid Treatment Strategy?
Tholen, S., Schmaderer, C., Chmielewski, S., Förstl, H., Heemann, U. W., Baumann, M., Steubl, D., & Grimmer, T. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150662 · Cited by 21 · see citing works
Hannan, M. F., Steffen, A. D., Quinn, L. T., Collins, E. G., Phillips, S. A., & Bronas, U. G. (2018) · Journal of Nephrology · doi:10.1007/s40620-018-0494-2 · Cited by 19 · see citing works
Lauridsen, M. M., Poulsen, L. K., Rasmussen, C. K., Høgild, M. L., Nielsen, M. K., de Muckadell, O. B. S., & Vilstrup, H. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9741-6 · Cited by 19 · see citing works
Histamine and H1 Antihistamines
Simons, F. E. R., & Akdiş, C. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-323-08593-9.00095-4 · Cited by 19 · see citing works
Wu, P., Lin, Y., Wu, P.-Y., Huang, J., Chen, S., Chang, J., & Chen, H. (2019) · Disease Markers · doi:10.1155/2019/9421352 · Cited by 18 · see citing works
Anwar, W., Ezzat, H., & Mohab, A. (2015) · Nefrología · doi:10.1016/j.nefro.2015.07.004 · Cited by 19 · see citing works
Li, A., Mu, J., Huang, M., Zhang, Z., Liu, J., & Zhang, M. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0254-y · Cited by 17 · see citing works
Samaei, A., Nobahar, M., Hydarinia-Naieni, Z., Ebrahimian, A., Tammadon, M. R., Ghorbani, R., & Vafaei, A. A. (2018) · BMC Nephrology · doi:10.1186/s12882-018-1134-8 · Cited by 19 · see citing works
Cognitive impairment burden in older and younger adults across the kidney transplant care continuum
Chu, N. M., Chen, X., Gross, A. L., Carlson, M. C., Garonzik‐Wang, J., Norman, S. P., Mathur, A., Abidi, M. Z., Brennan, D. C., Segev, D. L., et al. (2021) · Clinical Transplantation · doi:10.1111/ctr.14425 · Cited by 17 · see citing works
Dialysis for older adults: why should the targets be different?
Khatri, P., & Davenport, A. (2024) · Journal of Nephrology · doi:10.1007/s40620-023-01835-1 · Cited by 16 · see citing works
Increased arterial stiffness predicts cognitive impairment in hemodialysis patients
Tasmoc, A., Donciu, M., Veisa, G., Nistor, I., & Covic, A. C. (2016) · Hemodialysis International · doi:10.1111/hdi.12406 · Cited by 16 · see citing works
Cognitive impairment in hemodialysis patients: What can slow this decline?
Patel, M., Dasgupta, I., Tadros, G., & Baharani, J. (2015) · Hong Kong Journal of Nephrology · doi:10.1016/j.hkjn.2015.08.003 · Cited by 16 · see citing works
Musso, C. G., Trigka, K., Dousdampanis, P., & Jáuregui, J. R. (2014) · International Urology and Nephrology · doi:10.1007/s11255-014-0886-8 · Cited by 16 · see citing works
Palmer, S. C., Ruospo, M., Barulli, M. R., Iurillo, A., Saglimbene, V. M., Natale, P., Gargano, L., Murgo, A. M., Loy, C. T., van Zwieten, A., et al. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-009328 · Cited by 15 · see citing works
Cognitive function and exercise training for chronic renal disease patients: A literature review
Καλτσάτου, Α., Grigoriou, S. S., Karatzaferi, C., Giannaki, C. D., Stefanidis, I., & Sakkas, G. K. (2015) · Journal of Bodywork and Movement Therapies · doi:10.1016/j.jbmt.2015.04.006 · Cited by 15 · see citing works
Shea, Y. F., Lam, M.-F., Lee, M. S. C., Mok, M. Y. M., Lui, S., Yip, T. P. S., Lo, W. K., Chu, L., & Chan, T. M. (2015) · Clinical and Experimental Nephrology · doi:10.1007/s10157-015-1127-x · Cited by 15 · see citing works
Romijn, M. D. M., van Marum, R. J., Emmelot‐Vonk, M. H., Verhaar, H. J. J., & Koek, H. L. (2014) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4226 · Cited by 15 · see citing works
Lullmann, O., van der Plas, E. A. A., & Harshman, L. A. (2023) · Pediatric Transplantation · doi:10.1111/petr.14597 · Cited by 14 · see citing works
Li, L., Fisher, M., Lau, W. L., Moradi, H., Cheung, A., Thai, G. T., Handwerker, J., & Kalantar‐Zadeh, K. (2014) · Hemodialysis International · doi:10.1111/hdi.12210 · Cited by 14 · see citing works
Cerebral ischemia during hemodialysis—finding the signal in the noise
MacEwen, C., Watkinson, P., Tarassenko, L., & Pugh, C. W. (2018) · Seminars in Dialysis · doi:10.1111/sdi.12679 · Cited by 14 · see citing works
Oh, H., Mo, J.-A., & Seo, W. (2018) · Journal of Advanced Nursing · doi:10.1111/jan.13907 · Cited by 14 · see citing works
Wilson, S., Dhar, A. K., Tregaskis, P., Lambert, G. W., Barton, D., & Walker, R. G. (2018) · Nephrology · doi:10.1111/nep.13223 · Cited by 14 · see citing works
Neurocognitive deficits may not resolve following pediatric kidney transplantation
Lullmann, O., Conrad, A. L., Steinbach, E. J., Wilgenbusch, T. L. V., Harshman, L. A., & van der Plas, E. A. A. (2023) · Pediatric Transplantation · doi:10.1111/petr.14505 · Cited by 13 · see citing works
- Authors
- Tamura, M. K., Larive, B., Unruh, M. L., Stokes, J. B., Nissenson, A., Mehta, R. L., & Chertow, G. M.
- Affiliations
- VA Palo Alto Health Care System (US)
- Cleveland Clinic (US)
- University of Pittsburgh Medical Center (US)
- University of Iowa (US)
- University of California, Los Angeles (US)
- University of California San Diego (US)
- Stanford Medicine (US)
- Corresponding author
- Tamura, Manjula Kurella
- Mehta, Ravindra L.
- Chertow, Glenn M.
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2010-08
- Volume
- 5
- Issue
- 8
- Pages
- 1429-1438
- ISSN
- 1555-9041 (ISSN-L)
- PMC
- PMC2924414
- OpenAlex
- W2127784448
- Cited by
- 188
- References
- 34
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 15 · 2023: 12 · 2022: 11 · 2021: 16 · 2020: 13 · 2019: 8 · 2018: 14 · 2017: 14 · 2016: 14 · 2015: 13 · 2014: 18 · 2013: 7 · 2012: 10
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Journal of the American Society of Nephrology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Amgen
- National Institute on Aging (K23AG028952)
- National Institute of Diabetes and Digestive and Kidney Diseases (K24DK085446, U01 DK-03-005)
- Topics
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- cognitive impairment, hemodialysis, end-stage renal disease, executive function, global cognition, histamine H1 receptor antagonists, opioids, urea clearance, dietary biomarkers, anemia
- MeSH terms
- Adult, Aged, Analgesics, Opioid, Canada, Cognition, Cognition Disorders, Cross-Sectional Studies, Renal Dialysis, Histamine H1 Antagonists, Humans, Kidney Failure, Chronic, Middle Aged, Psychiatric Status Rating Scales, Risk Factors, Time Factors, United States, Multicenter Studies as Topic, Prevalence, Logistic Models, Odds Ratio, Randomized Controlled Trials as Topic, Treatment Outcome, Risk Assessment, Executive Function
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