The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Progression of Chronic Kidney Disease
Open accessAbstract
BACKGROUND AND OBJECTIVES: Chronic kidney disease (CKD) has recently assumed epidemic proportion, becoming a troubling emerging cause of morbidity, especially if it progresses to terminal stage (ESRD). The authors aimed to evaluate whether neutrophil gelatinase-associated lipocalin (NGAL), a novel specific biomarker of acute kidney injury, could predict the progression of CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Serum and urinary NGAL levels, together with a series of putative progression factors, were evaluated in a cohort of 96 patients (mean age: 57 +/- 16 years) affected by nonterminal CKD (eGFR > or =15 ml/min/1.73 m(2)) of various etiology. Progression of CKD, assessed as doubling of baseline serum creatinine and/or onset of ESRD, was evaluated during follow-up. RESULTS: At baseline, both serum and urinary NGAL were inversely, independently, and closely related to eGFR. After a median follow-up of 18.5 mo (range 1.01 to 20), 31 patients (32%) reached the composite endpoint. At baseline, these patients were significantly older and showed increased serum creatinine, calcium-phosphate product, C-reactive protein, fibrinogen, daily proteinuria, and NGAL levels, whereas eGFR values were significantly lower. Univariate followed by multivariate Cox proportional hazard regression analysis showed that urinary NGAL and sNGAL predicted CKD progression independently of other potential confounders, including eGFR and age. CONCLUSION: In patients with CKD, NGAL closely reflects the entity of renal impairment and represents a strong and independent risk marker for progression of CKD.
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Coresh, J., Selvin, E., Stevens, L. A., Manzi, J., Kusek, J. W., Eggers, P., Van Lente, F., & Levey, A. S. (2007) · JAMA · doi:10.1001/jama.298.17.2038 · Cited by 4,895
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NEUGARTEN, J., ACHARYA, A., & SILBIGER, S. R. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v112319 · Cited by 720
Predictors of the progression of renal disease in the Modification of Diet in Renal Disease Study
Modification of Diet in Renal Disease Study Group, Hunsicker, L. G., Adler, S., Caggiula, A., England, B. K., Greene, T., Kusek, J. W., Rogers, N. L., Teschan, P. E., & Beck, G. (1997) · Kidney International · doi:10.1038/ki.1997.260 · Cited by 702
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Neutrophil Gelatinase–Associated Lipocalin (NGAL) as a Marker of Kidney Damage
Bolignano, D., Donato, V., Coppolino, G., Campo, S., Buemi, A., Lacquaniti, A., & Buemi, M. (2008) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2008.01.020 · Cited by 581
Self-citationParikh, C. R., Jani, A., Mishra, J., Ma, Q., Kelly, C., Barasch, J., Edelstein, C. L., & Devarajan, P. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01352.x · Cited by 499
NGAL is an early predictive biomarker of contrast-induced nephropathy in children
Hirsch, R., Dent, C., Pfriem, H., Allen, J., Beekman, R. H., Ma, Q., Dastrala, S., Bennett, M., Mitsnefes, M., & Devarajan, P. (2007) · Pediatric Nephrology · doi:10.1007/s00467-007-0601-4 · Cited by 454
Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage
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Cited by
Neutrophil Gelatinase-Associated Lipocalin: A� Promising Biomarker for Human Acute Kidney Injury
Devarajan, P. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.10.12 · Cited by 332
Immunologic and endocrine functions of adipose tissue: implications for kidney disease
Zhu, Q., & Scherer, P. E. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.157 · Cited by 200
Eller, K., Schroll, A., Banas, M., Kirsch, A. H., Huber, J. M., Nairz, M., Skvortsov, S., Weiss, G., Rosenkranz, A. R., & Theurl, I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067693 · Cited by 46
Metadata
- Authors
- Bolignano, D., Lacquaniti, A., Coppolino, G., Donato, V., Campo, S., Fazio, M. R., Nicocia, G., & Buemi, M.
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2009-02
- Volume
- 4
- Issue
- 2
- Pages
- 337-344
- ISSN
- 1555-9041 (ISSN-L)
- OpenAlex
- W2160691052
- Cited by
- 561
- References
- 24
- FWCI
- 23.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Bolignano, D., Lacquaniti, A., Coppolino, G., Donato, V., Campo, S., Fazio, M. R., Nicocia, G., & Buemi, M. (2009). Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Progression of Chronic Kidney Disease. Clinical Journal of the American Society of Nephrology. https://doi.org/10.2215/cjn.03530708
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