The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Urine NGAL and IL-18 are Predictive Biomarkers for Delayed Graft Function Following Kidney Transplantation
Open accessAbstract
Delayed graft function (DGF) due to tubule cell injury frequently complicates deceased donor kidney transplants. We tested whether urinary neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) represent early biomarkers for DGF (defined as dialysis requirement within the first week after transplantation). Urine samples collected on day 0 from recipients of living donor kidneys (n = 23), deceased donor kidneys with prompt graft function (n = 20) and deceased donor kidneys with DGF (n = 10) were analyzed in a double blind fashion by ELISA for NGAL and IL-18. In patients with DGF, peak postoperative serum creatinine requiring dialysis typically occurred 2-4 days after transplant. Urine NGAL and IL-18 values were significantly different in the three groups on day 0, with maximally elevated levels noted in the DGF group (p < 0.0001). The receiver-operating characteristic curve for prediction of DGF based on urine NGAL or IL-18 at day 0 showed an area under the curve of 0.9 for both biomarkers. By multivariate analysis, both urine NGAL and IL-18 on day 0 predicted the trend in serum creatinine in the posttransplant period after adjusting for effects of age, gender, race, urine output and cold ischemia time (p < 0.01). Our results indicate that urine NGAL and IL-18 represent early, predictive biomarkers of DGF.
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Mishra, J., Ma, Q., Prada, A., Mitsnefes, M., Zahedi, K., Yang, J., Barasch, J., & Devarajan, P. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000088027.54400.c6 · Cited by 1,749
Self-citationDevarajan, P., Mishra, J., Supavekin, S., Patterson, L. T., & Steven Potter, S. (2003) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2003.09.012 · Cited by 229
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Cited by
Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Progression of Chronic Kidney Disease
Bolignano, D., Lacquaniti, A., Coppolino, G., Donato, V., Campo, S., Fazio, M. R., Nicocia, G., & Buemi, M. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03530708 · Cited by 561
Diagnosis, Epidemiology and Outcomes of Acute Kidney Injury
Waikar, S. S., Liu, K. D., & Chertow, G. M. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05191107 · Cited by 533
Chakraborty, S., Kaur, S., Guha, S., & Batra, S. K. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.03.008 · Cited by 503
Koyner, J. L., Bennett, M. R., Worcester, E. M., Ma, Q., Raman, J., Jeevanandam, V., Kasza, K. E., O'Connor, M. F., Konczal, D. J., Trevino, S., et al. (2008) · Kidney International · doi:10.1038/ki.2008.341 · Cited by 377
Self-citationNeutrophil Gelatinase-Associated Lipocalin: A� Promising Biomarker for Human Acute Kidney Injury
Devarajan, P. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.10.12 · Cited by 332
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Metadata
- Authors
- Parikh, C. R., Jani, A., Mishra, J., Ma, Q., Kelly, C., Barasch, J., Edelstein, C. L., & Devarajan, P.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2006-07
- Volume
- 6
- Issue
- 7
- Pages
- 1639-1645
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W1597457551
- Cited by
- 499
- References
- 2
- FWCI
- 24.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Parikh, C. R., Jani, A., Mishra, J., Ma, Q., Kelly, C., Barasch, J., Edelstein, C. L., & Devarajan, P. (2006). Urine NGAL and IL-18 are Predictive Biomarkers for Delayed Graft Function Following Kidney Transplantation. American Journal of Transplantation. https://doi.org/10.1111/j.1600-6143.2006.01352.x
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