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Cited by 55Potassium and Related DisordersSodium Intake and HealthIon Transport and Channel Regulation

Gut sensing of dietary K+ intake increases renal K+ excretion

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Oh, Ki-Sook, Oh, Young Taek, Kim, Sang-Wook, Kita, Toshihiro, Kang, Insug, Youn, Jang H.·2011·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
DOI 10.1152/ajpregu.00095.2011PMC PMC3154709
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Abstract

Dietary K(+) intake may increase renal K(+) excretion via increasing plasma [K(+)] and/or activating a mechanism independent of plasma [K(+)]. We evaluated these mechanisms during normal dietary K(+) intake. After an overnight fast, [K(+)] and renal K(+) excretion were measured in rats fed either 0% K(+) or the normal 1% K(+) diet. In a third group, rats were fed with the 0% K(+) diet, and KCl was infused to match plasma [K(+)] profile to that of the 1% K(+) diet group. The 1% K(+) feeding significantly increased renal K(+) excretion, associated with slight increases in plasma [K(+)], whereas the 0% K(+) diet decreased K(+) excretion, associated with decreases in plasma [K(+)]. In the KCl-infused 0% K(+) diet group, renal K(+) excretion was significantly less than that of the 1% K(+) group, despite matched plasma [K(+)] profiles. We also examined whether dietary K(+) alters plasma profiles of gut peptides, such as guanylin, uroguanylin, glucagon-like peptide 1, and glucose-dependent insulinotropic polypeptide, pituitary peptides, such as AVP, α-MSH, and γ-MSH, or aldosterone. Our data do not support a role for these hormones in the stimulation of renal K(+) excretion during normal K(+) intake. In conclusion, postprandial increases in renal K(+) excretion cannot be fully accounted for by changes in plasma [K(+)] and that gut sensing of dietary K(+) is an important component of the regulation of renal K(+) excretion. Our studies on gut and pituitary peptide hormones suggest that there may be previously unknown humoral factors that stimulate renal K(+) excretion during dietary K(+) intake.

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  • In experimental animals, when plasma K+ concentration is artificially maintained constant, the kaliuretic response to a K+ load is greater when given as a meal than with an intravenous infusion.

    “In experimental animals, when plasma K+ concentration is artificially maintained constant, the kaliuretic response to a K+ load is greater when given as a meal than with an intravenous infusion [19, 37].”

    From A mathematical model of potassium homeostasis: Effect of feedforward and feedback controls (2022) · cites this paper as [37]

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  1. [10]10. Gennari FJ. Hypokalemia. N Engl J Med 339: 451–458, 1998 [DOI] [PubMed] [Google Scholar]

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Authors
Oh, K.-S., Oh, Y. T., Kim, S.-W., Kita, T., Kang, I., & Youn, J. H.
Affiliations
  • University of Southern California (US)
  • University of Miyazaki (JP)
  • Kyung Hee University (KR)
Corresponding author
Youn, Jang H.
ORCID
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Published
2011-08
Volume
301
Issue
2
Pages
R421-R429
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
DOI
10.1152/ajpregu.00095.2011
PMC
PMC3154709
OpenAlex
W2127575901
Cited by
55
References
32
Citations by year
2026: 4 · 2025: 2 · 2023: 2 · 2022: 8 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 8 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 7 · 2012: 3
FWCI
3.54
Type
journal article
Language
en
Open access
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (DK-080233, R21DK080233)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
potassium intake, renal potassium excretion, plasma potassium, gut peptides, guanylin, uroguanylin, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, pituitary peptides, aldosterone, potassium chloride infusion
MeSH terms
Aldosterone, Amiloride, Animals, Blood Glucose, Gene Expression Regulation, Kidney, Male, Pituitary Hormones, Potassium, Sodium, Rats, Wistar, Potassium, Dietary, Postprandial Period, Sodium Channel Blockers, Gastrointestinal Tract, Rats

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