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A Systematic Review and Meta-Analysis of Outcomes of Pregnancy in CKD and CKD Outcomes in Pregnancy
Open accessAbstract
BACKGROUND AND OBJECTIVES: We undertook a systematic review and meta-analysis of published cohort studies and case-control studies to estimate (1) the risk of pregnancy complications among patients with CKD versus those without CKD and (2) the risk of CKD progression among pregnant patients versus nonpregnant controls with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We searched electronic databases for studies published between 1946 and 2014, and we reviewed articles using validity criteria. Random-effects analytical methods were used. RESULTS: Twenty-three studies (14 with data for adverse pregnancy outcomes and 9 for renal outcomes) with 506,340 pregnancies were included. Pregnancy with CKD had greater odds of preeclampsia (odds ratio [OR], 10.36; 95% confidence interval [95% CI], 6.28 to 17.09), premature delivery (OR, 5.72; 95% CI, 3.26 to 10.03), small for gestational age/low birth weight (OR, 4.85; 95% CI, 3.03 to 7.76), cesarean section (OR, 2.67; 95% CI, 2.01 to 3.54), and failure of pregnancy (OR, 1.80; 95% CI, 1.03 to 3.13). Subgroup analysis showed that odds of preeclampsia (P<0.01) and premature delivery (P<0.01) were higher in women with nondiabetic nephropathy compared with diabetic nephropathy, and the odds of preeclampsia (P=0.01) and premature delivery (P<0.01) were higher in women with macroproteinuria compared with microproteinuria. The median for follow-up time for renal events was 5 years (interquartile range, 5-14.7 years). There were no significant differences in the occurrence of renal events between CKD pregnant women and those without pregnancy (OR, 0.96; 95% CI, 0.69 to 1.35). Subgroup analysis showed that publication year, sample size, follow-up years, type of primary disease, CKD classification, level of serum creatinine at baseline, proteinuria, and level of systolic BP did not modify the renal outcomes. CONCLUSIONS: The risks of adverse maternal and fetal outcomes in pregnancy are higher for women with CKD versus pregnant women without CKD. However, pregnancy was not a risk factor for progression of renal disease in women with CKD before pregnancy.
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Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,451
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39489.470347.ad · Cited by 23,305
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2009.06.005 · Cited by 19,575
Prevalence of chronic kidney disease in China: a cross-sectional survey
Zhang, L., Wang, F., Wang, L., Wang, W., Liu, B., Liu, J., Chen, M., He, Q., Liao, Y., Yu, X., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60033-6 · Cited by 2,091
Self-citationEpidemiology: Study Design and Data Analysis
(2006) · Technometrics · doi:10.1198/tech.2006.s407 · Cited by 788
Prevalence of Kidney Damage in Australian Adults: The AusDiab Kidney Study
Chadban, S. J., Briganti, E. M., Kerr, P. G., Dunstan, D. W., Welborn, T. A., Zimmet, P. Z., & Atkins, R. C. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000070152.11927.4a · Cited by 683
Single data extraction generated more errors than double data extraction in systematic reviews
Buscemi, N., Hartling, L., Vandermeer, B., Tjosvold, L., & Klassen, T. P. (2006) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2005.11.010 · Cited by 464
Research works printed but not linked: 18
- Hou, 2007, Historical perspective of pregnancy in chronic kidney disease., Adv Chronic Kidney Dis, 14, 116, 10.1053/j.ackd.2007.01.001 · doi:10.1053/j.ackd.2007.01.001
- Vidaeff, 2008, Pregnancy in women with renal disease. Part I: General principles., Am J Perinatol, 25, 385, 10.1055/s-0028-1083837 · doi:10.1055/s-0028-1083837
- Piccoli, 2011, Pregnancy in chronic kidney disease: Need for a common language., J Nephrol, 24, 282, 10.5301/JN.2011.7978 · doi:10.5301/jn.2011.7978
- Abe, 1991, Pregnancy in IgA nephropathy., Kidney Int, 40, 1098, 10.1038/ki.1991.320 · doi:10.1038/ki.1991.320
- Limardo, 2010, Pregnancy and progression of IgA nephropathy: Results of an Italian multicenter study., Am J Kidney Dis, 56, 506, 10.1053/j.ajkd.2010.03.033 · doi:10.1053/j.ajkd.2010.03.033
- Abe, 1994, The influence of pregnancy on the long-term renal prognosis of IgA nephropathy., Clin Nephrol, 41, 61
- Shimizu, 2010, Effect of kidney disease stage on pregnancy and delivery outcomes among patients with immunoglobulin A nephropathy., Am J Nephrol, 32, 456, 10.1159/000320730 · doi:10.1159/000320730
- Trevisan, 2004, Pregnancy in patients with chronic renal insufficiency at Hospital de Clínicas of Porto Alegre, Brazil., Ren Fail, 26, 29, 10.1081/JDI-120028540 · doi:10.1081/jdi-120028540
- Hemmelder, 1995, Proteinuria: A risk factor for pregnancy-related renal function decline in primary glomerular disease?, Am J Kidney Dis, 26, 187, 10.1016/0272-6386(95)90173-6 · doi:10.1016/0272-6386(95)90173-6
- Jungers, 1995, Influence of pregnancy on the course of primary chronic glomerulonephritis., Lancet, 346, 1122, 10.1016/S0140-6736(95)91798-5 · doi:10.1016/s0140-6736(95)91798-5
- Barceló, 1986, Successful pregnancy in primary glomerular disease., Kidney Int, 30, 914, 10.1038/ki.1986.272 · doi:10.1038/ki.1986.272
- Leppert, 1979, Antecedent renal disease and the outcome of pregnancy., Ann Intern Med, 90, 747, 10.7326/0003-4819-90-5-747 · doi:10.7326/0003-4819-90-5-747
- Farwell, 2013, Outcomes of pregnancies complicated by chronic kidney disease., Am J Obstet Gynecol, 208, S153
- Limardo, 2010, [Pregnancy in women with renal disease: Consolidated evidence and open issues], G Ital Nefrol, 27, 444
- Bar, 1999, Pregnancy outcome in patients with insulin dependent diabetes mellitus and diabetic nephropathy treated with ACE inhibitors before pregnancy., J Pediatr Endocrinol Metab, 12, 659, 10.1515/JPEM.1999.12.5.659 · doi:10.1515/jpem.1999.12.5.659
- Hou, 1985, Pregnancy in women with renal disease and moderate renal insufficiency., Am J Med, 78, 185, 10.1016/0002-9343(85)90425-5 · doi:10.1016/0002-9343(85)90425-5
- Packham, 1988, IgA glomerulonephritis and pregnancy., Clin Nephrol, 30, 15
- Jungers, 1997, Pregnancy in women with impaired renal function., Clin Nephrol, 47, 281
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Magee, L. A., Brown, M. A., Hall, D. R., Gupte, S., Hennessy, A., Karumanchi, S. A., Kenny, L. C., McCarthy, F., Myers, J., Poon, L. C., et al. (2022) · Pregnancy Hypertension · doi:10.1016/j.preghy.2021.09.008 · Cited by 1,134
Garovic, V. D., Dechend, R., Easterling, T., Karumanchi, S. A., McMurtry Baird, S., Magee, L. A., Rana, S., Vermunt, J. V., August, P., & on behalf of the American Heart Association Council on Hypertension; Council on the Kidney in Cardiovascular Disease, K. I. H. D. S. C. C. O. A. (2022) · Hypertension · doi:10.1161/hyp.0000000000000208 · Cited by 598
Ndumele, C. E., Rodriguez, F., Dixon, D. L., Khan, S. S., Mukherjee, D., Bajaj, M., Bangalore, S., Bozkurt, B., Breathett, K., Clarke, S. L., et al. (2026) · JACC · doi:10.1016/j.jacc.2026.03.056 · Cited by 90
Metadata
- Authors
- Zhang, J.-J., Ma, X.-X., Hao, L., Liu, L.-J., Lv, J.-C., & Zhang, H.
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2015-11
- Volume
- 10
- Issue
- 11
- Pages
- 1964-1978
- ISSN
- 1555-9041 (ISSN-L)
- OpenAlex
- W2179664655
- Cited by
- 316
- References
- 27
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- green
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