The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Preeclampsia: Updates in Pathogenesis, Definitions, and Guidelines
Open accessAbstract
Preeclampsia is becoming an increasingly common diagnosis in the developed world and remains a high cause of maternal and fetal morbidity and mortality in the developing world. Delay in childbearing in the developed world feeds into the risk factors associated with preeclampsia, which include older maternal age, obesity, and/or vascular diseases. Inadequate prenatal care partially explains the persistent high prevalence in the developing world. In this review, we begin by presenting the most recent concepts in the pathogenesis of preeclampsia. Upstream triggers of the well described angiogenic pathways, such as the heme oxygenase and hydrogen sulfide pathways, as well as the roles of autoantibodies, misfolded proteins, nitric oxide, and oxidative stress will be described. We also detail updated definitions, classification schema, and treatment targets of hypertensive disorders of pregnancy put forth by obstetric and hypertensive societies throughout the world. The shift has been made to view preeclampsia as a systemic disease with widespread endothelial damage and the potential to affect future cardiovascular diseases rather than a self-limited occurrence. At the very least, we now know that preeclampsia does not end with delivery of the placenta. We conclude by summarizing the latest strategies for prevention and treatment of preeclampsia. A better understanding of this entity will help in the care of at-risk women before delivery and for decades after.
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Maynard, S. E., Min, J.-Y., Merchan, J., Lim, K.-H., Li, J., Mondal, S., Libermann, T. A., Morgan, J. P., Sellke, F. W., Stillman, I. E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17189 · Cited by 4,101
Circulating angiogenic factors and the risk of preeclampsia
Levine, R. J., Maynard, S. E., Qian, C., Lim, K.-H., England, L. J., Yu, K. F., Schisterman, E. F., Thadhani, R., Sachs, B. P., Epstein, F. H., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031884 · Cited by 3,720
Bellamy, L., Casas, J.-P., Hingorani, A. D., & Williams, D. J. (2007) · BMJ · doi:10.1136/bmj.39335.385301.be · Cited by 2,552
Soluble endoglin contributes to the pathogenesis of preeclampsia
Venkatesha, S., Toporsian, M., Lam, C., Hanai, J.-I., Mammoto, T., Kim, Y. M., Bdolah, Y., Lim, K.-H., Yuan, H.-T., Libermann, T. A., et al. (2006) · Nature Medicine · doi:10.1038/nm1429 · Cited by 1,855
Major congenital malformations after first-trimester exposure to ACE inhibitors
Cooper, W. O., Hernandez-Diaz, S., Arbogast, P. G., Dudley, J. A., Dyer, S., Gideon, P. S., Hall, K., & Ray, W. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055202 · Cited by 1,192
Placental oxidative stress: from miscarriage to preeclampsia
Burton, G. J., & Jauniaux, E. (2004) · Journal of the Society for Gynecologic Investigation · doi:10.1016/j.jsgi.2004.03.003 · Cited by 673
Less-Tight versus Tight Control of Hypertension in Pregnancy
Magee, L. A., von Dadelszen, P., Rey, E., Ross, S., Asztalos, E., Murphy, K. E., Menzies, J., Sanchez, J., Singer, J., Gafni, A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1404595 · Cited by 672
Veerbeek, J. H. W., Hermes, W., Breimer, A. Y., van Rijn, B. B., Koenen, S. V., Mol, B. W., Franx, A., de Groot, C. J. M., & Koster, M. P. H. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.04850 · Cited by 306
Cindrova-Davies, T., Herrera, E. A., Niu, Y., Kingdom, J., Giussani, D. A., & Burton, G. J. (2013) · The American Journal of Pathology · doi:10.1016/j.ajpath.2013.01.001 · Cited by 135
Cited by
Szilagyi, J. T., Avula, V., & Fry, R. C. (2020) · Current Environmental Health Reports · doi:10.1007/s40572-020-00279-0 · Cited by 328
The placenta and preeclampsia: villain or victim?
Melchiorre, K., Giorgione, V., & Thilaganathan, B. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.10.024 · Cited by 281
Environmental contaminants and preeclampsia: a systematic literature review
Rosen, E. M., Muñoz, M. I., McElrath, T., Cantonwine, D. E., & Ferguson, K. K. (2018) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937404.2018.1554515 · Cited by 74
“Further, there are most likely different subtypes of preeclampsia that need to be identified and analyzed separately (Phipps et al. 2016).”
BackgroundLewandowska, M., Więckowska, B., Sajdak, S., & Lubiński, J. (2020) · Nutrients · doi:10.3390/nu12092681 · Cited by 49
Metadata
- Authors
- Phipps, E., Prasanna, D., Brima, W., & Jim, B.
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2016-04-19
- Volume
- 11
- Issue
- 6
- Pages
- 1102-1113
- ISSN
- 1555-9041 (ISSN-L)
- 1555-905X
- OpenAlex
- W2341276202
- Cited by
- 622
- References
- 9
- FWCI
- 51.42
- Type
- journal article
- Language
- en
- Open access
- green
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