Reduced Cystathionine γ-Lyase and Increased miR-21 Expression Are Associated with Increased Vascular Resistance in Growth-Restricted Pregnancies
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Increased vascular impedance in the fetoplacental circulation is associated with fetal hypoxia and growth restriction. We sought to investigate the role of hydrogen sulfide (H2S) in regulating vasomotor tone in the fetoplacental vasculature. H2S is produced endogenously by catalytic activity of cystathionine β-synthase and cystathionine γ-lyase (CSE). Immunohistochemical analysis localized CSE to smooth muscle cells encircling arteries in stem villi. Immunoreactivity was reduced in placentas from pregnancies with severe early-onset growth-restriction and preeclampsia displaying abnormal umbilical artery Doppler waveforms compared with preeclamptic placentas with normal waveforms and controls. These findings were confirmed at the protein and mRNA levels. MicroRNA-21, which negatively regulates CSE expression, was increased in placentas with abnormal Doppler waveforms. Exposure of villus explants to hypoxia-reoxygenation significantly reduced CSE protein and mRNA and increased microRNA-21 expression. No changes were observed in cystathionine β-synthase expression, immunolocalized principally to the trophoblast, in pathologic placentas or in vitro. Finally, perfusion of normal placentas with an H2S donor, after preconstriction with a thromboxane mimetic, resulted in dose-dependent vasorelaxation. Glibenclamide and N(G)-nitro-l-arginine methyl ester partially blocked the effect, indicating that H2S acts through ATP-sensitive K(+) channels and nitric oxide synthesis. These results demonstrate that H2S is a powerful vasodilator of the placental vasculature and that expression of CSE is reduced in placentas associated with increased vascular resistance.
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CBS and CSE have been immunolocalized to the syncytiotrophoblast and also to the smooth muscle cells surrounding the stem villus arteries in the human placenta.
“CBS and CSE have been immunolocalized to the syncytiotrophoblast and also to the smooth muscle cells surrounding the stem villus arteries in the human placenta (111, 262).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [111]
Hydrogen sulfide is a powerful vasodilator of the fetal placental vasculature, and its effects are mediated through actions on both ATP-sensitive K+ channels and nitric oxide.
“Perfusion experiments ex vivo have demonstrated that hydrogen sulfide is a powerful vasodilator of the fetal placental vasculature, and that its effects are mediated through actions on both ATP-sensitive K + channels and nitric oxide (111).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [111]
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- Authors
- Cindrova-Davies, T., Herrera, E. A., Niu, Y., Kingdom, J., Giussani, D. A., & Burton, G. J.
- Affiliations
- University of Cambridge (GB)
- Mount Sinai Hospital (CA)
- Corresponding author
- Burton, Graham J.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 182
- Issue
- 4
- Pages
- 1448-1458
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC3608014
- OpenAlex
- W2104477359
- Cited by
- 135
- References
- 54
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 11 · 2023: 6 · 2022: 6 · 2021: 14 · 2020: 14 · 2019: 6 · 2018: 13 · 2017: 14 · 2016: 13 · 2015: 13 · 2014: 11 · 2013: 6
- FWCI
- 15.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- American Journal Of Pathology (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Funders
- Wellcome Trust (084804/2/08/Z)
- Universidad de Chile
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- cystathionine gamma-lyase, hydrogen sulfide, miR-21, fetal growth restriction, preeclampsia, placental vasculature, vascular resistance, umbilical artery Doppler, fetal hypoxia, cystathionine beta-synthase, hypoxia/reoxygenation, vasodilation, ATP-sensitive potassium channels, nitric oxide, stem villi, trophoblast
- MeSH terms
- Hypoxia, Cystathionine beta-Synthase, Cystathionine gamma-Lyase, Female, Fetal Growth Retardation, Gene Expression Regulation, Humans, Hydrogen Sulfide, Perfusion, Placenta, Pregnancy, RNA, Messenger, Vascular Resistance, Vasodilator Agents, Gene Expression Profiling, MicroRNAs, In Vitro Techniques
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