The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Long-Chain Acyl-Coa Synthetases And Fatty Acid Channeling
Open accessAbstract
Thirteen homologous proteins comprise the long-chain acyl-CoA synthetase (ACSL), fatty acid transport protein (FATP), and bubblegum (ACSBG) subfamilies that activate long-chain and very-long-chain fatty acids to form acyl-CoAs. Gain- and loss-of-function studies show marked differences in the ability of these enzymes to channel fatty acids into different pathways of complex lipid synthesis. Further, the ability of the ACSLs and FATPs to enhance cellular FA uptake does not always require these proteins to be present on the plasma membrane; instead, FA uptake can be increased by enhancing its conversion to acyl-CoA and its metabolism in downstream pathways. Since altered fatty acid metabolism is a hallmark of numerous metabolic diseases and pathological conditions, the ACSL, FATP and ACSBG isoforms are likely to play important roles in disease etiology.
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Cites
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POLYUNSATURATED FATTY ACID REGULATION OF GENES OF LIPID METABOLISM
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Cited by
Liu, L., MacKenzie, K. R., Putluri, N., Maletić-Savatić, M., & Bellen, H. J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.024 · Cited by 556
Layé, S., Nadjar, A., Joffre, C., & Bazinet, R. P. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014092 · Cited by 420
Rose, J., Brian, C., Pappa, A., Panayiotidis, M. I., & Franco, R. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.536682 · Cited by 196
Watt, M. J., & Hoy, A. J. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00561.2011 · Cited by 142
Nie, C., Sun, Y., Zhen, H., Guo, M., Ye, J., Liu, Z., Yang, Y., & Zhang, X. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00438 · Cited by 89
Metadata
- Authors
- Mashek, D. G., Li, L. O., & Coleman, R. A.
- Venue
- Future Lipidology
- Publisher
- Informa UK Limited
- Published
- 2007-08-01
- Volume
- 2
- Issue
- 4
- Pages
- 465-476
- ISSN
- 1746-0875 (ISSN-L)
- OpenAlex
- W1986813347
- Cited by
- 279
- References
- 98
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
