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Cited by 196Mitochondrial Function and PathologyNeuroscience and Neuropharmacology ResearchAmino Acid Enzymes and Metabolism

Mitochondrial metabolism in astrocytes regulates brain bioenergetics, neurotransmission and redox balance

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Rose, Jordan, Brian, Christian, Pappa, Aglaia, Panayiotidis, Mihalis I., Franco, Rodrigo·2020·Frontiers in Neuroscience
DOI 10.3389/fnins.2020.536682PMC PMC7674659
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Abstract

In the brain, mitochondrial metabolism has been largely associated with energy production, and its dysfunction is linked to neuronal cell loss. However, the functional role of mitochondria in glial cells has been poorly studied. Recent reports have demonstrated unequivocally that astrocytes do not require mitochondria to meet their bioenergetics demands. Then, the question remaining is, what is the functional role of mitochondria in astrocytes? In this work, we review current evidence demonstrating that mitochondrial central carbon metabolism in astrocytes regulates overall brain bioenergetics, neurotransmitter homeostasis and redox balance. Emphasis is placed in detailing carbon source utilization (glucose and fatty acids), anaplerotic inputs and cataplerotic outputs, as well as carbon shuttles to neurons, which highlight the metabolic specialization of astrocytic mitochondria and its relevance to brain function.

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Cited by

Sorted by citations

Authors
Rose, J., Brian, C., Pappa, A., Panayiotidis, M. I., & Franco, R.
Affiliations
  • University of Nebraska–Lincoln (US)
  • Democritus University of Thrace (GR)
  • Cyprus Institute of Neurology and Genetics (CY)
Corresponding author
Franco, Rodrigo
ORCID
Venue
Frontiers in Neuroscience
Publisher
Frontiers Media SA
Published
2020-11-05
Volume
14
Pages
536682-536682
ISSN
1662-453X (ISSN-L)
DOI
10.3389/fnins.2020.536682
PMC
PMC7674659
OpenAlex
W3094724728
Cited by
196
References
21
Citations by year
2026: 29 · 2025: 31 · 2024: 64 · 2023: 35 · 2022: 26 · 2021: 11
FWCI
1.76
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Lincoln (University of Nebraska) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health
  • Office of Research and Economic Development, University of Nebraska-Lincoln
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords
astrocytes, mitochondrial metabolism, brain bioenergetics, neurotransmitter homeostasis, redox homeostasis, central carbon metabolism, glucose utilization, fatty acid oxidation, anaplerosis, cataplerosis, astrocyte-neuron metabolic coupling

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