Cited by 161Circular RNAs in diseasesTreatment of Major DepressionRNA regulation and disease

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Hsa_Circrna_103636: Potential Novel Diagnostic and Therapeutic Biomarker in Major Depressive Disorder

Cui, Xuelian, Niu, Wei, Kong, Lingming, He, Mingjun, Jiang, Kunhong, Chen, Shengdong, Zhong, Aifang, Li, Wanshuai, Lu, Jim, Zhang, Liyi·2016·Biomarkers in Medicine

Abstract

AIM: This study aimed to determine whether circular RNA (circRNA) molecules in peripheral blood mononuclear cells (PBMCs) could be used as novel non-invasive biomarkers for major depressive disorder (MDD). MATERIALS & METHODS: Differentially expressed circRNAs were screened using an Arraystar Human CircRNA Array (which includes 13,617 human circRNAs) and qRT-PCR. Thirty MDD patients were randomly selected to retest the circRNA levels after 4-week and 8-week antidepressant regimens. RESULTS: Four differentially expressed circRNAs were identified between MDD patients and controls, and only down-regulated hsa_circRNA_103636 was significantly altered after the 8-week treatment in MDD patients. CONCLUSION: These results suggest that altered expression of hsa_circRNA_103636 in PBMCs is a potential novel biomarker for the diagnosis and treatment of MDD.

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Crossref · 10.2217/bmm-2016-0130

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Metadata

Authors
Cui, X., Niu, W., Kong, L., He, M., Jiang, K., Chen, S., Zhong, A., Li, W., Lu, J., & Zhang, L.
Affiliations
  • Nanjing Medical University (CN)
  • Chinese People's Liberation Army (CN)
  • Gopath Diagnostic Laboratory Co Ltd, No. 801, Changzhou, People’s Republic of China
  • Prevention & Treatment Center for Psychological Diseases, No. 102 Hospital of Chinese People’s Liberation Army, Changzhou, People’s Republic of China
Venue
Biomarkers in Medicine
Published
2016-07-12
Volume
10
Issue
9
Pages
943-952
ISSN
  • 1752-0363 (ISSN-L)
  • 1752-0371
OpenAlex
W2474303280
Cited by
150
References
47
Citations by year
2026: 2 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 11 · 2021: 23 · 2020: 31 · 2019: 14 · 2018: 34 · 2017: 8 · 2016: 2
FWCI
10.04
Type
journal article
Language
en
Open access
closed
Locations
  • Biomarkers in Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords
circular RNA, major depressive disorder, peripheral blood mononuclear cells, non-invasive biomarkers, antidepressant response, differentially expressed circRNAs, depression diagnosis
MeSH terms
RNA, Circular, Adult, Antidepressive Agents, Major Depressive Disorder, Female, Humans, Leukocytes, Mononuclear, Male, Middle Aged, Prognosis, RNA, Biomarkers, Down-Regulation, Case-Control Studies, Gene Expression Profiling, Real-Time Polymerase Chain Reaction

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