Cited by 161Circular RNAs in diseasesTreatment of Major DepressionRNA regulation and disease

hsa_circRNA_103636: potential novel diagnostic and therapeutic biomarker in Major depressive disorder

Cui, Xuelian, Niu, Wei, Kong, Lingming, He, Mingjun, Jiang, Kunhong, Chen, Shengdong, Zhong, Aifang, Li, Wanshuai +2 more·2016·Biomarkers in Medicine

Abstract

AIM: This study aimed to determine whether circular RNA (circRNA) molecules in peripheral blood mononuclear cells (PBMCs) could be used as novel non-invasive biomarkers for major depressive disorder (MDD). MATERIALS & METHODS: Differentially expressed circRNAs were screened using an Arraystar Human CircRNA Array (which includes 13,617 human circRNAs) and qRT-PCR. Thirty MDD patients were randomly selected to retest the circRNA levels after 4-week and 8-week antidepressant regimens. RESULTS: Four differentially expressed circRNAs were identified between MDD patients and controls, and only down-regulated hsa_circRNA_103636 was significantly altered after the 8-week treatment in MDD patients. CONCLUSION: These results suggest that altered expression of hsa_circRNA_103636 in PBMCs is a potential novel biomarker for the diagnosis and treatment of MDD.

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Crossref · 10.2217/bmm-2016-0130

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  • Cui et al. identified four differentially expressed circRNAs (hsa_circRNA_002143, hsa_circRNA_103636, hsa_circRNA_100679, and hsa_circRNA_104953) between depression patients and controls using qRT-PCR and a human circRNA array.

    “Cui et al. identified four differentially expressed circRNAs, namely hsa_-circRNA_002143, hsa_circRNA_103636, hsa_circRNA_100679, and hsa_circRNA_104953, between depression patients and controls using quantitative Real-time Polymerase Chain Reaction (qRT-PCR) and a human circRNA array, which included 13,617 human circRNAs [77].”
  • After 4-week and 8-week antidepressant regimens such as citalopram combined with mirtazapine, only down-regulated hsa_circRNA_103636 recovered to normal levels.

    “After 4-week and 8-week antidepressant regimens such as citalopram combined with mirtazapine, only down-regulated hsa_circRNA_103636 recovered to normal levels, suggesting the potential value of hsa_circRNA_103636 in the diagnosis and treatment of depression [77].”
  • hsa_circRNA_103636 has potential value in the diagnosis and treatment of depression.

    “After 4-week and 8-week antidepressant regimens such as citalopram combined with mirtazapine, only down-regulated hsa_circRNA_103636 recovered to normal levels, suggesting the potential value of hsa_circRNA_103636 in the diagnosis and treatment of depression [77].”
  • hsa_circRNA_104600 (VDAC3) is downregulated in blood.

    “| 13 | hsa_circRNA_104600 | VDAC3 | | | √ | Blood | [77] |”
  • hsa_circRNA_103964 (UBE2D2) is upregulated in blood.

    “| 9 | hsa_circRNA_103964 | UBE2D2 | | √ | | Blood | [77] |”

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Authors
Cui, X., Niu, W., Kong, L., He, M., Jiang, K., Chen, S., Zhong, A., Li, W., Lu, J., & Zhang, L.
Affiliations
  • Nanjing Medical University (CN)
  • Chinese People's Liberation Army (CN)
  • Gopath Diagnostic Laboratory Co Ltd, No. 801, Changzhou, People’s Republic of China
  • Prevention & Treatment Center for Psychological Diseases, No. 102 Hospital of Chinese People’s Liberation Army, Changzhou, People’s Republic of China
Venue
Biomarkers in Medicine
Published
2016-07-12
Volume
10
Issue
9
Pages
943-952
ISSN
  • 1752-0363 (ISSN-L)
  • 1752-0371
OpenAlex
W2474303280
Cited by
150
References
47
Citations by year
2026: 2 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 11 · 2021: 23 · 2020: 31 · 2019: 14 · 2018: 34 · 2017: 8 · 2016: 2
FWCI
10.04
Type
journal article
Language
en
Open access
closed
Locations
  • Biomarkers in Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords
circular RNA, major depressive disorder, peripheral blood mononuclear cells, non-invasive biomarkers, antidepressant response, differentially expressed circRNAs, depression diagnosis
MeSH terms
RNA, Circular, Adult, Antidepressive Agents, Major Depressive Disorder, Female, Humans, Leukocytes, Mononuclear, Male, Middle Aged, Prognosis, RNA, Biomarkers, Down-Regulation, Case-Control Studies, Gene Expression Profiling, Real-Time Polymerase Chain Reaction

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