The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Hsa_Circrna_103636: Potential Novel Diagnostic and Therapeutic Biomarker in Major Depressive Disorder
Abstract
AIM: This study aimed to determine whether circular RNA (circRNA) molecules in peripheral blood mononuclear cells (PBMCs) could be used as novel non-invasive biomarkers for major depressive disorder (MDD). MATERIALS & METHODS: Differentially expressed circRNAs were screened using an Arraystar Human CircRNA Array (which includes 13,617 human circRNAs) and qRT-PCR. Thirty MDD patients were randomly selected to retest the circRNA levels after 4-week and 8-week antidepressant regimens. RESULTS: Four differentially expressed circRNAs were identified between MDD patients and controls, and only down-regulated hsa_circRNA_103636 was significantly altered after the 8-week treatment in MDD patients. CONCLUSION: These results suggest that altered expression of hsa_circRNA_103636 in PBMCs is a potential novel biomarker for the diagnosis and treatment of MDD.
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In the citing paper
“Cui et al. identified four differentially expressed circRNAs, namely hsa_-circRNA_002143, hsa_circRNA_103636, hsa_circRNA_100679, and hsa_circRNA_104953, between depression patients and controls using quantitative Real-time Polymerase Chain Reaction (qRT-PCR) and a human circRNA array, which included 13,617 human circRNAs [77].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [77]
In the citing paper
“After 4-week and 8-week antidepressant regimens such as citalopram combined with mirtazapine, only down-regulated hsa_circRNA_103636 recovered to normal levels, suggesting the potential value of hsa_circRNA_103636 in the diagnosis and treatment of depression [77].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [77]
In the citing paper
“After 4-week and 8-week antidepressant regimens such as citalopram combined with mirtazapine, only down-regulated hsa_circRNA_103636 recovered to normal levels, suggesting the potential value of hsa_circRNA_103636 in the diagnosis and treatment of depression [77].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [77]
In the citing paper
“| 13 | hsa_circRNA_104600 | VDAC3 | | | √ | Blood | [77] |”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [77]
In the citing paper
“| 9 | hsa_circRNA_103964 | UBE2D2 | | √ | | Blood | [77] |”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [77]
In the citing paper
“| 6 | hsa_circRNA_002143 | RNA5-8S5 | Human | √ | | Blood | [77] |”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [77]
In the citing paper
“| 7 | hsa_circRNA_100679 | SH3PXD2A | Human | | √ | Blood | [77] |”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [77]
In the citing paper
“| 11 | hsa_circRNA_100018 | GNB1 | | | √ | Blood | [77] |”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [77]
In the citing paper
“| 12 | hsa_circRNA_103257 | CELSR1 | | | √ | Blood | [77] |”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [77]
In the citing paper
“| 10 | hsa_circRNA_104121 | TRAM2 | | √ | | Blood | [77] |”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [77]
In the citing paper
“| 14 | hsa_circRNA_102802 | LOC541471 | | | √ | Blood | [77] |”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [77]
In the citing paper
“| 8 | hsa_circRNA_104953 | GTF3C5 | Human | | √ | Blood | [77] |”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [77]
In the citing paper
“| 5 | hsa_circRNA_103636 | DCUN1D4 | Human | | √ | Blood | [77] |”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [77]
Citations
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Circular RNAs are abundant, conserved, and associated with ALU repeats
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Cell-Type Specific Features of Circular RNA Expression
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Using circular RNA as a novel type of biomarker in the screening of gastric cancer
Li, P., Chen, S., Chen, H., Mo, X., Li, T., Shao, Y., Xiao, B., & Guo, J. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.02.018 · Cited by 779
Cited by
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Circular RNA and its mechanisms in disease: From the bench to the clinic
Han, B., Chao, J., & Yao, H. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.01.010 · Cited by 788
Role of circular RNAs in brain development and CNS diseases
Mehta, S. L., Dempsey, R. J., & Vemuganti, R. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101746 · Cited by 281
Global circular RNA expression profile of human gastric cancer and its clinical significance
Shao, Y., Li, J., Lu, R., Li, T., Yang, Y., Xiao, B., & Guo, J. (2017) · Cancer Medicine · doi:10.1002/cam4.1055 · Cited by 268
Circular RNAs (circRNAs) in Health and Disease
Haque, S., & Harries, L. W. (2017) · Genes · doi:10.3390/genes8120353 · Cited by 272
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246
Metadata
- Authors
- Cui, X., Niu, W., Kong, L., He, M., Jiang, K., Chen, S., Zhong, A., Li, W., Lu, J., & Zhang, L.
- Affiliations
- Nanjing Medical University (CN)
- Chinese People's Liberation Army (CN)
- Gopath Diagnostic Laboratory Co Ltd, No. 801, Changzhou, People’s Republic of China
- Prevention & Treatment Center for Psychological Diseases, No. 102 Hospital of Chinese People’s Liberation Army, Changzhou, People’s Republic of China
- Venue
- Biomarkers in Medicine
- Publisher
- Informa UK Limited
- Published
- 2016-07-12
- Volume
- 10
- Issue
- 9
- Pages
- 943-952
- ISSN
- 1752-0363 (ISSN-L)
- 1752-0371
- OpenAlex
- W2474303280
- Cited by
- 150
- References
- 47
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 11 · 2021: 23 · 2020: 31 · 2019: 14 · 2018: 34 · 2017: 8 · 2016: 2
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomarkers in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- circular RNA, major depressive disorder, peripheral blood mononuclear cells, non-invasive biomarkers, antidepressant response, differentially expressed circRNAs, depression diagnosis
- MeSH terms
- RNA, Circular, Adult, Antidepressive Agents, Major Depressive Disorder, Female, Humans, Leukocytes, Mononuclear, Male, Middle Aged, Prognosis, RNA, Biomarkers, Down-Regulation, Case-Control Studies, Gene Expression Profiling, Real-Time Polymerase Chain Reaction
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