Cited by 161Circular RNAs in diseasesTreatment of Major DepressionRNA regulation and disease

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Hsa_Circrna_103636: Potential Novel Diagnostic and Therapeutic Biomarker in Major Depressive Disorder

Cui, Xuelian, Niu, Wei, Kong, Lingming, He, Mingjun, Jiang, Kunhong, Chen, Shengdong, Zhong, Aifang, Li, Wanshuai, Lu, Jim, Zhang, Liyi·2016·Biomarkers in Medicine

DOI 10.2217/bmm-2016-0130

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Abstract

AIM: This study aimed to determine whether circular RNA (circRNA) molecules in peripheral blood mononuclear cells (PBMCs) could be used as novel non-invasive biomarkers for major depressive disorder (MDD). MATERIALS & METHODS: Differentially expressed circRNAs were screened using an Arraystar Human CircRNA Array (which includes 13,617 human circRNAs) and qRT-PCR. Thirty MDD patients were randomly selected to retest the circRNA levels after 4-week and 8-week antidepressant regimens. RESULTS: Four differentially expressed circRNAs were identified between MDD patients and controls, and only down-regulated hsa_circRNA_103636 was significantly altered after the 8-week treatment in MDD patients. CONCLUSION: These results suggest that altered expression of hsa_circRNA_103636 in PBMCs is a potential novel biomarker for the diagnosis and treatment of MDD.

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Authors: Cui, X., Niu, W., Kong, L., He, M., Jiang, K., Chen, S., Zhong, A., Li, W., Lu, J., & Zhang, L.
Affiliations: Nanjing Medical University (CN)
Chinese People's Liberation Army (CN)
Gopath Diagnostic Laboratory Co Ltd, No. 801, Changzhou, People’s Republic of China
Prevention & Treatment Center for Psychological Diseases, No. 102 Hospital of Chinese People’s Liberation Army, Changzhou, People’s Republic of China
ORCID: Cui, Xuelian
Kong, Lingming
He, Mingjun
Chen, Shengdong
Zhong, Aifang
Li, Wanshuai
Lu, Jim
Venue: Biomarkers in Medicine
Publisher: Informa UK Limited
Published: 2016-07-12
Volume: 10
Issue: 9
Pages: 943-952
ISSN: 1752-0363 (ISSN-L)
1752-0371
DOI: 10.2217/bmm-2016-0130
OpenAlex: W2474303280
Cited by: 150
References: 47
Citations by year: 2026: 2 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 11 · 2021: 23 · 2020: 31 · 2019: 14 · 2018: 34 · 2017: 8 · 2016: 2
FWCI: 10.04
Type: journal article
Language: en
Open access: closed
Locations: Biomarkers in Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: circular RNA, major depressive disorder, peripheral blood mononuclear cells, non-invasive biomarkers, antidepressant response, differentially expressed circRNAs, depression diagnosis
MeSH terms: RNA, Circular, Adult, Antidepressive Agents, Major Depressive Disorder, Female, Humans, Leukocytes, Mononuclear, Male, Middle Aged, Prognosis, RNA, Biomarkers, Down-Regulation, Case-Control Studies, Gene Expression Profiling, Real-Time Polymerase Chain Reaction

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Hsa_Circrna_103636: Potential Novel Diagnostic and Therapeutic Biomarker in Major Depressive Disorder

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