The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
Intracellular Coenzymes as Natural Biomarkers for Metabolic Activities and Mitochondrial Anomalies
Open accessAbstract
Mitochondria play a pivotal role in energy metabolism, programmed cell death and oxidative stress. Mutated mitochondrial DNA in diseased cells compromises the structure of key enzyme complexes and, therefore, mitochondrial function, which leads to a myriad of health-related conditions such as cancer, neurodegenerative diseases, diabetes and aging. Early detection of mitochondrial and metabolic anomalies is an essential step towards effective diagnoses and therapeutic intervention. Reduced nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD) play important roles in a wide range of cellular oxidation-reduction reactions. Importantly, NADH and FAD are naturally fluorescent, which allows noninvasive imaging of metabolic activities of living cells and tissues. Furthermore, NADH and FAD autofluorescence, which can be excited using distinct wavelengths for complementary imaging methods and is sensitive to protein binding and local environment. This article highlights recent developments concerning intracellular NADH and FAD as potential biomarkers for metabolic and mitochondrial activities.
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3D microtumors in vitro supported by perfused vascular networks
Sobrino, A., Phan, D. T. T., Datta, R., Wang, X., Hachey, S. J., Romero-López, M., Gratton, E., Lee, A. P., George, S. C., & Hughes, C. C. W. (2016) · Scientific Reports · doi:10.1038/srep31589 · Cited by 387
Fluorescence Lifetime Imaging Microscopy for Quantitative Biological Imaging
Chen, L.-C., Lloyd, W. R., Chang, C.-W., Sud, D., & Mycek, M.-A. (2013) · Methods in Cell Biology · doi:10.1016/b978-0-12-407761-4.00020-8 · Cited by 55
Sensors and Techniques for On-Line Determination of Cell Viability in Bioprocess Monitoring
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Conley, K. E., Ali, A. S., Flores, B., Jubrias, S. A., & Shankland, E. G. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00045 · Cited by 22
Metadata
- Authors
- Heikal, A. A.
- Venue
- Biomarkers in Medicine
- Publisher
- Informa UK Limited
- Published
- 2010-04
- Volume
- 4
- Issue
- 2
- Pages
- 241-263
- ISSN
- 1752-0363 (ISSN-L)
- 1752-0371
- OpenAlex
- W2024901091
- Cited by
- 458
- References
- 157
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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