Cost–effectiveness of elagolix versus leuprolide acetate for treating moderate-to-severe endometriosis pain in the USA
Open accessAbstract
AIM: To assess the cost-effectiveness of elagolix versus leuprolide acetate in women with moderate to severe endometriosis pain. METHODS: A Markov model was developed. The efficacy of leuprolide acetate was derived from statistical prediction models using elagolix trial data. Model inputs were extracted from Phase III clinical trials and published literature. RESULTS: Compared with leuprolide acetate, elagolix generated positive net monetary benefit (NMB) assuming a payer's willingness-to-pay threshold of US$100,000 per quality-adjusted life year over a 1-year time horizon: US$5660 for elagolix 150 mg and US$6443 for elagolix 200 mg. The 2-year NMBs were also positive. CONCLUSION: Elagolix was cost effective versus leuprolide acetate in the management of moderate to severe endometriosis pain over 1- and 2-year time horizons. Results were robust in sensitivity analyses.
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According to Wang et al., the two recent FDA-approved doses of elagolix for management of moderate-to-severe pain associated with endometriosis, namely 24 months of 150 mg once daily or six months of 200 mg twice daily, both proved cost-effective versus leuprolide acetate over 1-2 years.
“Moreover, according to Wang et al. [125], the two recent FDA-approved doses of elagolix for the management of moderate-to-severe pain associated with endometriosis, namely, 24 months of 150 mg once daily or six months of 200 mg twice daily, both proved cost-effective versus leuprolide acetate over 1–2 years.”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [125]
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Introducing Volume 9 of the Journal of Comparative Effectiveness Research
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- Authors
- Wang, S.-T., Johnson, S. J., Mitchell, D., Soliman, A. M., Vora, J. B., & Agarwal, S. K.
- Affiliations
- Medtronic (India) (IN)
- AbbVie (United States) (US)
- University of California San Diego (US)
- Venue
- Journal of Comparative Effectiveness Research
- Publisher
- Becaris Publishing Limited
- Published
- 2019-04
- Volume
- 8
- Issue
- 5
- Pages
- 337-355
- ISSN
- 2042-6305 (ISSN-L)
- 2042-6313
- OpenAlex
- W2912011793
- Cited by
- 22
- References
- 53
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 1
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Journal of Comparative Effectiveness Research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- elagolix, leuprolide, endometriosis-associated pain, cost-effectiveness, net monetary benefit, quality-adjusted life years, Markov model, GnRH agonist, GnRH antagonist, endometriosis treatment
- MeSH terms
- Adolescent, Adult, Cost-Benefit Analysis, Endometriosis, Female, Fertility Agents, Female, Humans, Hydrocarbons, Fluorinated, Markov Chains, Middle Aged, Pain, Pyrimidines, Severity of Illness Index, United States, Leuprolide, Models, Economic, Young Adult
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