Social determinants of late-life depression epigenetics

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the chicago health, aging, and social relations study

Cacioppo, J. T., Hawkley, L. C., & Thisted, R. A. (2010) · Psychology and Aging · doi:10.1037/a0017216 · Cited by 1,757 · see citing works

Late-Life Depression, Mild Cognitive Impairment, and Dementia: Possible Continuum?

Panza, F., Frisardi, V., Capurso, C. A., D’Introno, A., Colacicco, A. M., Imbimbo, B. P., Santamato, A., Vendemiale, G., Seripa, D., Pilotto, A., et al. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181b0fa13 · Cited by 609 · see citing works

Social neuroscience and health: neurophysiological mechanisms linking social ties with physical health

Eisenberger, N. I., & Cole, S. W. (2012) · Nature Neuroscience · doi:10.1038/nn.3086 · Cited by 590 · see citing works

Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning

Levine, M. E., Lu, A. T., Bennett, D. A., & Horvath, S. (2015) · Aging · doi:10.18632/aging.100864 · Cited by 455 · see citing works

A computational and neural model of momentary subjective well-being

Rutledge, R. B., Skandali, N., Dayan, P., & Dolan, R. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407535111 · Cited by 444 · see citing works

A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression

Guintivano, J., Aryee, M. J., & Kaminsky, Z. A. (2013) · Epigenetics · doi:10.4161/epi.23924 · Cited by 369 · see citing works

Loneliness and stress-related inflammatory and neuroendocrine responses in older men and women

Hackett, R. A., Hamer, M., Endrighi, R., Brydon, L., & Steptoe, A. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.016 · Cited by 272 · see citing works

Epigenetic aging in major depressive disorder

Han, L. K. M., Aghajani, M., Clark, S. L., Chan, R. F., Hattab, M. W., Shabalin, A. A., Zhao, M., Kumar, G., Xie, L. Y., Jansen, R., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17060595 · Cited by 260 · see citing works

The epigenetic impacts of social stress: how does social adversity become biologically embedded?

Cunliffe, V. T. (2016) · Epigenomics · doi:10.2217/epi-2016-0075 · Cited by 141 · see citing works

BDNF promoter methylation and genetic variation in late-life depression

Januar, V, Ancelin, M.-L., Ritchie, K., Saffery, R., & Ryan, J. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.114 · Cited by 139 · see citing works

Longitudinal Association of Depression Symptoms With Cognition and Cortical Amyloid Among Community-Dwelling Older Adults

Gatchel, J. R., Rabin, J. S., Buckley, R. F., Locascio, J. J., Quiroz, Y. T., Yang, H., Vannini, P., Amariglio, R. E., Rentz, D. M., Properzi, M. J., et al. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.8964 · Cited by 131 · see citing works

Genetic architecture of epigenetic and neuronal ageing rates in human brain regions

Lu, A. T.-H., Hannon, E. J., Levine, M. E., Crimmins, E. M., Lunnon, K., Mill, J. S., Geschwind, D. H., & Horvath, S. (2017) · Nature Communications · doi:10.1038/ncomms15353 · Cited by 125 · see citing works

Brain Changes in Response to Long Antarctic Expeditions

Stahn, A. C., Gunga, H., Kohlberg, E., Gallinat, J., Dinges, D. F., & Kühn, S. (2019) · New England Journal of Medicine · doi:10.1056/nejmc1904905 · Cited by 120 · see citing works

Differential patterns of nucleus accumbens activation during anticipation of monetary and social reward in young and older adults

Rademacher, L., Salama, A., Gründer, G., & Spreckelmeyer, K. N. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst047 · Cited by 114 · see citing works

Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression

Lam, D., Ancelin, M., Ritchie, K. A., Freak‐Poli, R., Saffery, R., & Ryan, J. L. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1850-4 · Cited by 104 · see citing works

Engagement in Socially and Interpersonally Rewarding Activities as a Predictor of Outcome in “Engage” Behavioral Activation Therapy for Late-Life Depression

Solomonov, N., Bress, J. N., Sirey, J. A., Gunning, F. M., Flückiger, C., Raue, P. J., Areán, P. A., & Alexopoulos, G. S. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.12.033 · Cited by 100 · see citing works

Assessment and treatment of major depression in older adults

(2019) · Handbook of Clinical Neurology · doi:10.1016/b978-0-12-804766-8.00023-6 · Cited by 73 · see citing works

Social Dysfunction in Older Age and Relationships with Cognition, Depression, and Apathy: The GreatAGE Study

Lozupone, M., Panza, F., Piccininni, M., Copetti, M., Sardone, R., Imbimbo, B. P., Stella, E., D’Urso, F., Barulli, M. R., Battista, P., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180466 · Cited by 47 · see citing works

Implications of the Association of Social Exclusion With Mental Health

Heinz, A., Zhao, X., & Liu, S. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.3009 · Cited by 44 · see citing works

How Does Psychosocial Behavior Contribute to Cognitive Health in Old Age?

Wilson, R., & Bennett, D. A. (2017) · Brain Sciences · doi:10.3390/brainsci7060056 · Cited by 36 · see citing works

Characterizing the nuclear and cytoplasmic transcriptomes in developing and mature human cortex uncovers new insight into psychiatric disease gene regulationPreprint

Price, A. J., Hwang, T., Tao, R., Burke, E. E., Rajpurohit, A., Shin, J. H., Hyde, T. M., Kleinman, J. E., Jaffe, A. E., & Weinberger, D. R. (2019) · Genome Research · doi:10.1101/gr.250217.119 · Cited by 32 · see citing works

Longitudinal associations between glucocorticoid receptor methylation and late-life depression

Kang, H.-J., Bae, K.-Y., Kim, S.-W., Shin, I.-S., Kim, H.-R., Shin, M.-G., Yoon, J.-S., & Kim, J.-M. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.02.004 · Cited by 30 · see citing works

Characterizing the nuclear and cytoplasmic transcriptomes in developing and mature human cortex uncovers new insight into psychiatric disease gene regulationPreprint

Price, A. J., Hwang, T., Tao, R., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/567966 · Cited by 10 · see citing works

Genetic and Epigenetic Regulation of the Serotonin Transporter Gene in Late-Life Depression

Ryan, J. L., & Ancelin, M. (2019) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988719841725 · Cited by 7 · see citing works

The impact of COVID-19 infection and enforced prolonged social isolation on neuropsychiatric symptoms in older adults with and without dementia: A review

Manca, R., De Marco, M., & Venneri, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.585540 · Cited by 227 · see citing works

Depressive and Biopsychosocial Frailty Phenotypes: Impact on Late-life Cognitive Disorders

Panza, F., Solfrizzi, V., Sardone, R., Dibello, V., Castellana, F., Zupo, R., Stallone, R., Lampignano, L., Bortone, I., Mollica, A., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230312 · Cited by 57 · see citing works

Social Frailty in the COVID-19 Pandemic Era

Lozupone, M., Montagna, M. L., Gioia, I. D., Sardone, R., Resta, E., Daniele, A., Giannelli, G., Bellomo, A., & Panza, F. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.577113 · Cited by 35 · see citing works

Design and protocol of the multimorbidity and mental health cohort study in frailty and aging (MiMiCS-FRAIL): unraveling the clinical and molecular associations between frailty, somatic disease burden and late life depression

Aprahamian, I., Mamoni, R. L., Cervigne, N. K., Augusto, T. M., Romanini, C. V., Petrella, M., da Costa, D. L., Lima, N. A., Borges, M. K., & Voshaar, R. C. O. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02963-9 · Cited by 25 · see citing works

Evaluation of DNA methylation in <i>BDNF</i> , <i>SLC6A4</i> , <i>NR3C1</i> and <i>FKBP5</i> before and after treatment with selective serotonin-reuptake inhibitor in major depressive disorder

Mohammadi, S., Beh-Pajooh, A., Ahmadimanesh, M., Amini, M., Ghazi-Khansari, M., Moallem, S. A., Hosseini, R., Nourian, Y. H., & Ghahremani, M. H. (2022) · Epigenomics · doi:10.2217/epi-2022-0246 · Cited by 23 · see citing works

Perspective: Social Determinants of Mental Health for the New Decade of Healthy Aging

Jeste, D. V., Koh, S., & Pender, V. B. (2022) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2022.01.006 · Cited by 21 · see citing works

The epigenetics of frailty.

Lozupone, M., Solfrizzi, V., Sardone, R., Dibello, V., Castellana, F., Zupo, R., Lampignano, L., Bortone, I., Daniele, A., & Panza, F. (2023) · Epigenomics · doi:10.2217/epi-2023-0279 · Cited by 17 · see citing works

The association of FKBP5 gene polymorphism with genetic susceptibility to depression and response to antidepressant treatment- a systematic review

Zhang, Y., Yue, W., & Li, J. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05717-z · Cited by 15 · see citing works

Late-Onset Depression but not Early-Onset Depression may Increase the Risk of All-Cause Mortality in Older Age: 8-Year Follow-Up of the Salus in Apulia Study

Lozupone, M., Castellana, F., Sardone, R., Berardino, G., Mollica, A., Zupo, R., Pergola, G. D., Griseta, C., Stallone, R., Montagna, M. L., et al. (2022) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2022.12.005 · Cited by 13 · see citing works

Late-onset depression is associated to age-related central auditory processing disorder in an older population in Southern Italy

Lozupone, M., Sardone, R., Donghia, R., D’Urso, F., Piccininni, C., Battista, P., Gioia, I. D., Resta, E., Castellana, F., Lampignano, L., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00290-1 · Cited by 10 · see citing works

Therapeutic factors and mechanisms of change in music therapy for people with late-life depression: A scoping review

van Essen, K., Akse, M., Pelgrim, T. C., Prick, A.-E. J. C., & Aalbers, S. (2025) · The Arts in Psychotherapy · doi:10.1016/j.aip.2025.102289 · Cited by 9 · see citing works

Psychiatry and sensation: the epigenetic links

Lozupone, M., Leccisotti, I., Altamura, M., Moretti, M. C., Bellomo, A., Daniele, A., Dibello, V., Resta, E., & Panza, F. (2024) · Epigenomics · doi:10.1080/17501911.2024.2410692 · Cited by 3 · see citing works

Neurobiology of “Positive Psychiatry”

Jeste, D. V. (2022) · Schizophrenia Bulletin · doi:10.1093/schbul/sbac023 · Cited by 3 · see citing works

The epigenetic mechanisms of ketamine in the treatment of depression: a systematic review

Leccisotti, I., Moretti, M. C., Altamura, M., Bellomo, A., Laurello, R., Carapellese, M., Sborgia, G., Dibello, V., Robert, G., Panza, F., et al. (2025) · Epigenomics · doi:10.1080/17501911.2025.2583892 · Cited by 2 · see citing works

Editorial: Tracing loneliness in aging: understanding the interplay and exploring innovative interventions

Lozupone, M., Altamura, M., Bellomo, A., & Panza, F. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1904840

Late-life depression in socially and culturally diverse settings

Gureje, O. (2020) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796020000815 · Cited by 7 · see citing works

The Epidemiology of Late Life Depression

Blazer, D. G. (1982) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1982.tb05669.x · Cited by 60 · see citing works

[Epidemiology of late life depression].

Bonnewyn, A., Bruffaerts, R., & Demyttenaere, K. (2006) · PubMed · Cited by 1 · see citing works

The epidemiologic face of late-life depression.

Murphy, J. M. (1989) · PubMed · Cited by 3 · see citing works

Epigenetics: Where Environment, Society and Genetics Meet

Majnik, A. V., & Lane, R. H. (2014) · Epigenomics · doi:10.2217/epi.13.83 · Cited by 28 · see citing works