The DOI matches its Crossref record; 191 of the 191 references it cites were found in a registry or an index.
Methyl-CpG-Binding Domain Proteins: Readers of the Epigenome
Open accessAbstract
How DNA methylation is interpreted and influences genome regulation remains largely unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates for the readout of DNA methylation as they recruit chromatin remodelers, histone deacetylases and methylases to methylated DNA associated with gene repression. MBD protein binding requires both functional MBD domains and methyl-CpGs; however, some MBD proteins also bind unmethylated DNA and active regulatory regions via alternative regulatory domains or interaction with the nucleosome remodeling deacetylase (NuRD/Mi-2) complex members. Mutations within MBD domains occur in many diseases, including neurological disorders and cancers, leading to loss of MBD binding specificity to methylated sites and gene deregulation. Here, we summarize the current state of knowledge about MBD proteins and their role as readers of the epigenome.
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“5mC readers including proteins containing a methyl-CpG-binding domain such as MECP2 or MBD proteins can recognize 5mC and recruit co-regulators to methylated DNA (25).”
From Dynamic DNA methylation: In the right place at the right time (2018) · cites this paper as [25]
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Cites
1 retracted
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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
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Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
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Dynamic DNA methylation: In the right place at the right time
Luo, C., Hajkova, P., & Ecker, J. R. (2018) · Science · doi:10.1126/science.aat6806 · Cited by 668
Molecular mechanisms of transgenerational epigenetic inheritance
Fitz-James, M. H., & Cavalli, G. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-021-00438-5 · Cited by 589
Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
Yang, J., Xu, J., Wang, W. T., Zhang, B., Yu, X., & Shi, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01480-x · Cited by 412
Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy
Biswas, S., & Rao, C. M. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.08.021 · Cited by 442
Sensitivity of transcription factors to DNA methylation
Héberlé, É., & Bardet, A. F. (2019) · Essays in Biochemistry · doi:10.1042/ebc20190033 · Cited by 347
Metadata
- Authors
- Du, Q., Luu, P.-L., Stirzaker, C., & Clark, S. J.
- Affiliations
- Garvan Institute of Medical Research (AU)
- Venue
- Epigenomics
- Publisher
- Informa UK Limited
- Published
- 2015-04-30
- Volume
- 7
- Issue
- 6
- Pages
- 1051-1073
- ISSN
- 1750-1911 (ISSN-L)
- 1750-192X
- OpenAlex
- W2040875973
- Cited by
- 544
- References
- 191
- Citations by year
- 2026: 34 · 2025: 61 · 2024: 55 · 2023: 53 · 2022: 74 · 2021: 72 · 2020: 43 · 2019: 47 · 2018: 34 · 2017: 35 · 2016: 23 · 2015: 5
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Epigenomics (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- NHMRC Fellowship and NHMRC (1088144)
- Stirzaker and P-L Luu by NHMRC (1088144)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Keywords
- methyl-CpG binding domain proteins, DNA methylation, epigenetic reader protein, chromatin remodeling, histone deacetylase, gene repression, neurological disorders, cancer, gene expression regulation
- MeSH terms
- Animals, Binding Sites, Cell Differentiation, DNA-Binding Proteins, Gene Expression Regulation, Multigene Family, Humans, Mutation, Neoplasms, Protein Binding, Down-Regulation, CpG Islands, DNA Methylation, Genetic Predisposition to Disease, Gene Silencing, Epigenesis, Genetic, Protein Interaction Domains and Motifs, Cellular Reprogramming
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