Cited by 383Epigenetics and DNA MethylationGenomics and Chromatin DynamicsChromatin Remodeling and Cancer

Sensitivity of transcription factors to DNA methylation

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Héberlé, Éléa, Bardet, Anaïs Flore·2019·Essays in Biochemistry

Abstract

Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional states throughout organism development. Epigenetics modifications, such as DNA methylation mostly within cytosine-guanine dinucleotides (CpGs), have the potential to modulate TF binding to DNA. Although DNA methylation has long been thought to repress TF binding, a more recent model proposes that TF binding can also inhibit DNA methylation. Here, we review the possible scenarios by which DNA methylation and TF binding affect each other. Further in vivo experiments will be required to generalize these models.

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Crossref · 10.1042/ebc20190033

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  • When a recruited transcription factor is inhibitory, DNA methylation results in enhanced gene expression.

    “When a recruited transcription factor is inhibitory, DNA methylation results in enhanced gene expression.58”

    From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [58]

    In ‘DNA methylation represses TF binding’ (page unavailable), the review describes a specific case: methylation prevents the insulating factor CTCF from binding at the mouse Igf2-H19 locus, allowing an enhancer to activate Igf2. This supports the proposed mechanism, but not the unqualified claim that methylation enhances gene expression whenever an inhibitory transcription factor is involved; the review says the functional effects of methylation-sensitive binding remain to be investigated more broadly. (LLM, conf=0.83)

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Authors
Héberlé, É., & Bardet, A. F.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Bardet, Anaïs Flore
Venue
Essays in Biochemistry
Published
2019-11-22
Volume
63
Issue
6
Pages
727-741
ISSN
  • 0071-1365 (ISSN-L)
  • 1744-1358
OpenAlex
W2990086739
Cited by
347
References
99
Citations by year
2026: 30 · 2025: 45 · 2024: 82 · 2023: 61 · 2022: 69 · 2021: 38 · 2020: 20 · 2019: 1
FWCI
2.83
Type
journal article
Language
en
Open access
Locations
  • Essays in Biochemistry (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
Funders
Agence Nationale de la Recherche (ANR-10-IDEX-0002)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
transcription factors, DNA methylation, CpG, transcription factor binding, epigenetic regulation, transcriptional repression, regulatory elements, epigenetic inheritance
MeSH terms
Animals, DNA, Humans, Protein Binding, Transcription Factors, DNA Methylation, Epigenesis, Genetic

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