The DOI matches its Crossref record; 183 of the 184 references it cites were found in a registry or an index.
Neurobiology of dysregulated motivational systems in drug addiction
Open accessAbstract
The progression from recreational drug use to drug addiction impacts multiple neurobiological processes and can be conceptualized as a transition from positive to negative reinforcement mechanisms driving both drug-taking and drug-seeking behaviors. Neurobiological mechanisms for negative reinforcement, defined as drug taking that alleviates a negative emotional state, involve changes in the brain reward system and recruitment of brain stress (or antireward) systems within forebrain structures, including the extended amygdala. These systems are hypothesized to be dysregulated by excessive drug intake and to contribute to allostatic changes in reinforcement mechanisms associated with addiction. Points of intersection between positive and negative motivational circuitry may further drive the compulsivity of drug addiction but also provide a rich neurobiological substrate for therapeutic intervention.
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“and the upregulation of a postsynaptic Gs/cAMP/PKA signalling pathway in the nucleus accumbens might constitute a critical neuroadaptation that is central to the establishment and maintenance of the addicted state.136,137”
From Neurobiology of addiction: a neurocircuitry analysis (2016) · cites this paper as [137]
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Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
Aston-Jones, G., & Cohen, J. D. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135709 · Cited by 4,472
Olds, J., & Milner, P. (1954) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0058775 · Cited by 3,176
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Self-citationThe Neural Basis of Addiction: A Pathology of Motivation and Choice
Kalivas, P. W., & Volkow, N. D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1403 · Cited by 2,757
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647
Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535
Self-citationCellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
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Research works printed but not linked: 4
- American Psychiatric Association: Diagnositc and Statistical Manual of Mental Disorders (4th Edition) . American Psychiatric Press Washington DC USA (2000).
- Whisler K , HallS, EdwardsS, AkkentliF, SelfDW: Tonic activation of NAc PKA signaling facilitates D2 receptor-mediated relapse to cocaine seeking and locomotor activity.Abstr. Soc. Neurosci.29, 420.417 (2003).
- Larson EB , WhislerK, SmagulaCet al.: Preferential over-expression of Gs-α in direct and indirect striatal output pathways differentially alters cocaine-taking and -seeking behaviors.Soc. Neurosci. Abstr.35 (2009) (Abstract 649.11).
- Renthal W , TerziD, OlsonEN, NestlerEJ, ZachariouV: Histone deacetylase 5 controls analgesic responsiveness to tricyclic antidepressants in a mouse model of neuropathic pain.Soc. Neurosci. Abstr.34 (2008) (Abstract 368.6).
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Neurobiology of addiction: a neurocircuitry analysis
Koob, G. F., & Volkow, N. D. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)00104-8 · Cited by 3,698
Self-citationThe dark side of emotion: the addiction perspective
Koob, G. F. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.11.044 · Cited by 433
Self-citationAddiction is a Reward Deficit and Stress Surfeit Disorder
Koob, G. F. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00072 · Cited by 397
Self-citationAlcohol dependence as a chronic pain disorder
Egli, M., Koob, G. F., & Edwards, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.010 · Cited by 347
Self-citationClarifying the roles of homeostasis and allostasis in physiological regulation.
Ramsay, D. S., & Woods, S. C. (2014) · Psychological Review · doi:10.1037/a0035942 · Cited by 365
Metadata
- Authors
- Edwards, S., & Koob, G. F.
- Affiliations
- Scripps Research Institute (US)
- Venue
- Future Neurology
- Publisher
- Informa UK Limited
- Published
- 2010-05-05
- Volume
- 5
- Issue
- 3
- Pages
- 393-410
- ISSN
- 1479-6708 (ISSN-L)
- 1748-6971
- PMC
- PMC2886284
- OpenAlex
- W2163582947
- Semantic Scholar
- 543b3e9c9f2569f1549b9b9f2e206e9c70e83938
- Cited by
- 157
- References
- 184
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 4 · 2021: 15 · 2020: 14 · 2019: 11 · 2018: 11 · 2017: 14 · 2016: 14 · 2015: 8 · 2014: 8 · 2013: 14 · 2012: 9
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Future Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA008459, F32AA018250, P50AA006420, R37AA008459, P60AA006420)
- National Institute on Drug Abuse (R01DA010072, R01DA023597, R01DA004398, R01DA004043, R01DA023957)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK026741)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- drug addiction, motivation system, negative reinforcement, positive reinforcement, brain reward system, extended amygdala, stress system, compulsivity, drug-seeking behavior, drug use behavior, addiction treatment
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