Cell-fusion events induced by α-herpesviruses

Ambrosini, Anthony E; Enquist, Lynn W

doi:10.2217/fvl.14.100

Cited by 15Herpesvirus Infections and TreatmentsCytomegalovirus and herpesvirus researchVirology and Viral Diseases

Cell-fusion events induced by α-herpesviruses

Ambrosini, Anthony E, Enquist, Lynn W·2015·Future Virology

DOI 10.2217/fvl.14.100

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Abstract

Enveloped viruses encode proteins that can induce cell fusion to allow spread of infection without exposure to immune surveillance. In this review, we discuss cell fusion events caused by neurotropic α-herpesviruses. Syncytia (large, multinucleated cells) are clinically indicative of α herpesvirus infections, and peripheral neuropathies are clinical hallmarks. We examine the viral and cellular factors required for cell fusion, as well as mutations which confer a more aggressive ‘hypersyncytial’ phenotype. Finally, we consider the causes of fusion events in infected neurons, and the implications for neuronal dysfunction and pathophysiology.

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In general, herpesviruses are equipped with a set of glycoproteins (gD, gB, gH, and gL) that carry out all fusion events either between the virus and cells or between infected and non-infected cells.
“In general, herpesviruses are equipped with a set of glycoproteins (gD, gB, gH, and gL) that carry out all fusion events either between the virus and cells or between infected and non-infected cells (Ambrosini and Enquist, 2015; Atanasiu et al., 2010).”
From Equid Herpesvirus-1 Exploits the Extracellular Matrix of Mononuclear Cells to Ensure Transport to Target Cells (2020) · cites this paper as Ambrosini and Enquist, 2015

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Authors: Ambrosini, A. E., & Enquist, L. W.
Affiliations: Princeton University (US)
ORCID: Enquist, Lynn W
Venue: Future Virology
Publisher: Informa UK Limited
Published: 2015-02
Volume: 10
Issue: 2
Pages: 185-200
ISSN: 1746-0794 (ISSN-L)
1746-0808
DOI: 10.2217/fvl.14.100
OpenAlex: W2064421567
Cited by: 15
References: 114
Citations by year: 2026: 1 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1
FWCI: 0.79
Type: journal article
Language: en
Open access: closed
Locations: Future Virology (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords: cell fusion, alphaherpesvirus, syncytia, peripheral neuropathy, neuronal dysfunction, viral fusion protein, immune evasion

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Cell-fusion events induced by α-herpesviruses

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