The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Factors Relating to the Biodistribution & Clearance of Nanoparticles & Their Effects on In Vivo Application
Abstract
Nanoparticles have promising biomedical applications for drug delivery, tumor imaging and tumor treatment. Pharmacokinetics are important for the in vivo application of nanoparticles. Biodistribution and clearance are largely defined as the key points of pharmacokinetics to maximize therapeutic efficacy and to minimize side effects. Different engineered nanoparticles have different biodistribution and clearance processes. The interactions of organs with nanoparticles, which are determined by the characteristics of the organs and the biochemical/physical properties of the nanoparticles, are a major factor influencing biodistribution and clearance. In this review, the clearance functions of organs and the properties related to pharmacokinetics, including nanoparticle size, shape, biodegradation and surface modifications are discussed.
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Cites
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Cited by
Mendes, B. B., Conniot, J., Avital, A., Yao, D., Jiang, X., Zhou, X., Sharf-Pauker, N., Xiao, Y., Adir, O., Liang, H., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00104-y · Cited by 719
Inorganic nanomaterials with rapid clearance for biomedical applications
Wang, X., Zhong, X., Li, J., Liu, Z., & Cheng, L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00461h · Cited by 509
Lignin for Nano‐ and Microscaled Carrier Systems: Applications, Trends, and Challenges
Sipponen, M. H., Lange, H., Crestini, C., Henn, A., & Österberg, M. (2019) · ChemSusChem · doi:10.1002/cssc.201900480 · Cited by 284
Domingues, C., Santos, A., Alvarez-Lorenzo, C., Concheiro, A., Jarak, I., Veiga, F., Barbosa, I., Dourado, M., & Figueiras, A. (2022) · ACS Nano · doi:10.1021/acsnano.2c00128 · Cited by 235
Tanaka, M., Araujo, A. C., Valenti, V. E., Guiguer, E. L., Catharin, V. C. S., Gualhardi, C. M., de Souza Bastos Mazuqueli Pereira, E., de Alvares Goulart, R., de Argolo Haber, R. S., de Carvalho, A. C. A., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052370 · Cited by 13
Metadata
- Authors
- Wei, Y., Quan, L., Zhou, C., & Zhan, Q.
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2018-06
- Volume
- 13
- Issue
- 12
- Pages
- 1495-1512
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2855863311
- Cited by
- 234
- References
- 7
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wei, Y., Quan, L., Zhou, C., & Zhan, Q. (2018). Factors Relating to the Biodistribution & Clearance of Nanoparticles & Their Effects on In Vivo Application. Nanomedicine. https://doi.org/10.2217/nnm-2018-0040
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