Functionalized Carbon Nanotubes: Revolution in Brain Delivery
Open accessAbstract
Biocompatible functionalized carbon nanotubes Carbon nanotubes (CNTs) are firstly described by Iijima in early nineties as needle-like tubes composed of layers of graphitic sheets [1]. Either single-walled or multiwalled carbon nanotubes (SWNTs or MWNTs), made of one or several layers of graphene, have been utilized mainly in industry due to their characteristic high mechanical strength, good electronic and thermal properties [2]. Together with the large surface area, the relatively low weight makes them ideal particularly for applications in neuroengineering [3]. However, due to the hydrophobic nature, pristine CNTs cannot be functionally integrated into biological systems unless they undergo surface fictionalization to become more biocompatible. Many approaches have been developed to alter the inert property of CNTs either through covalent (e.g., oxidation and chemical conjugation) or noncovalent (e.g., coating with hydrophilic or biological molecules) strategies [4]. Since then, functionalized CNTs (f-CNTs), possessing reduced cytotoxicity, have received tremendous attention as nanomaterials in biomedicine. In particular, f-CNTs held great promise as drug or gene carriers in vitro and in vivo [5,6].
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Functionalized CNTs can overcome the blood-brain barrier.
“Recent studies exhibited that functionalized CNTs can overcome the blood-brain barrier.113”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [113]
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- Authors
- Wang, J. T.-W., & Al-Jamal, K. T.
- Affiliations
- King's College London (GB)
- Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King’s College London, London, SE1 9NH, UK
- ORCID
- Wang, Julie Tzu-Wen
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2015-09
- Volume
- 10
- Issue
- 17
- Pages
- 2639-2642
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2193774287
- Cited by
- 53
- References
- 22
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 2 · 2021: 6 · 2020: 9 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 1 · 2014: 3
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- creativecommons.org/licenses/by/4.0/ (vor)
- Locations
- Nanomedicine (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Research Portal (King's College London) (submittedVersion, cc-by-nc)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/J008656/1)
- Worldwide Cancer Research (12–1054)
- Wellcome Trust (WT103913MF)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Physical Sciences › Materials Science › Materials Chemistry › Carbon Nanotubes in Composites
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- functionalized carbon nanotubes, brain drug delivery, biocompatibility, surface functionalization, covalent functionalization, non-covalent functionalization, neural engineering, drug carriers, gene carriers, cytotoxicity, single-walled carbon nanotubes, multi-walled carbon nanotubes
- MeSH terms
- Animals, Biocompatible Materials, Blood-Brain Barrier, Brain, DNA, Genetic Vectors, Humans, Swine, Drug Delivery Systems, Gene Transfer Techniques, Nanotubes, Carbon, Nanostructures, Nanomedicine, Mice, Rats
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