The effect of whole body vibration on fracture healing - a systematic review
Open accessAbstract
This systematic review examines the efficacy and safety of whole body vibration (WBV) on fracture healing. A systematic literature search was conducted with relevant keywords in PubMed and Embase, independently, by two reviewers. Original animal and clinical studies about WBV effects on fracture healing with available full-text and written in English were included. Information was extracted from the included studies for review. In total, 19 articles about pre-clinical studies were selected. Various vibration regimes are reported; of those, the frequencies of 35 Hz and 50 Hz show better results than others. Most of the studies show positive effects on fracture healing after vibration treatment and the responses to vibration are better in ovariectomised (OVX) animals than non-OVX ones. However, several studies provide insufficient evidence to support an improvement of fracture healing after vibration and one study even reports disruption of fracture healing after vibration. In three studies, vibration results in positive effects on angiogenesis at the fracture site and surrounding muscles during fracture healing. No serious complications or side effects of vibration are found in these studies. WBV is suggested to be beneficial in improving fracture healing in animals without safety problem reported. In order to apply vibration on fractured patients, more well-designed randomised controlled clinical trials are needed to examine its efficacy, regimes and safety.
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Cites
1 retracted
Iwamoto, J., Takeda, T., Satō, Y., & Uzawa, M. (2005) · Aging Clinical and Experimental Research · doi:10.1007/bf03324589 · Cited by 161 · see citing works
RetractedOsteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · see citing works
(1990) · Elsevier eBooks · doi:10.1016/c2009-0-02730-5 · Cited by 1,829 · see citing works
The Cell and Molecular Biology of Fracture Healing
Einhorn, T. A. (1998) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199810001-00003 · Cited by 1,280 · see citing works
Biology of RANK, RANKL, and osteoprotegerin
Boyce, B. F., & Xing, L. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2165 · Cited by 962 · see citing works
Mechanotransduction and the functional response of bone to mechanical strain
Duncan, R., & Turner, C. (1995) · Calcified Tissue International · doi:10.1007/bf00302070 · Cited by 944 · see citing works
Vibration as an exercise modality: how it may work, and what its potential might be
Rittweger, J. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1303-3 · Cited by 870 · see citing works
The Use of Vibration as an Exercise Intervention
Cardinale, M., & Bosco, C. (2003) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200301000-00002 · Cited by 836 · see citing works
Verschueren, S. M., Roelants, M., Delecluse, C., Swinnen, S., Vanderschueren, D., & Boonen, S. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.0301245 · Cited by 833 · see citing works
Carano, R. A. D., & Filvaroff, E. H. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(03)02866-6 · Cited by 743 · see citing works
Effects of Mechanical Factors on the Fracture Healing Process
Claes, L., Heigele, C. A., Neidlinger‐Wilke, C., Kaspar, D., Seidl, W., Margevicius, K. J., & Augat, P. (1998) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199810001-00015 · Cited by 709 · see citing works
Rubin, C. T., Recker, R. R., Cullen, D. M., Ryaby, J. P., McCabe, J., & McLeod, K. J. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.0301251 · Cited by 592 · see citing works
Kalfas, I. H. (2001) · Neurosurgical FOCUS · doi:10.3171/foc.2001.10.4.2 · Cited by 499 · see citing works
Whole body vibration exercise: are vibrations good for you?
Cardinale, M., & Wakeling, J. M. (2005) · British Journal of Sports Medicine · doi:10.1136/bjsm.2005.016857 · Cited by 483 · see citing works
Low Magnitude Mechanical Loading Is Osteogenic in Children With Disabling Conditions
Ward, K. A., Alsop, C. W., Caulton, J. M., Rubin, C. T., Adams, J. E., & Zulf Mughal, M. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040129 · Cited by 432 · see citing works
Gilsanz, V., Wren, T. A. L., Sanchez, M., Dorey, F. J., Judex, S., & Rubin, C. T. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060612 · Cited by 370 · see citing works
Rauch, F., Sievänen, H., Boonen, S., Cardinale, M., Degens, H., Felsenberg, D., Roth, J., Schöenau, E., Verschueren, S., & Rittweger, J. (2010) · PubMed · Cited by 337 · see citing works
Exercise and Sport Sciences Reviews.
Wilmore, J. H., Hutton, R. S., Miller, D. I., Terjung, R. L., PANDOLF, K. B., & Holloszy, J. O. (1981) · Cited by 316 · see citing works
Luu, Y. K., Capilla, E., Rosen, C. J., Gilsanz, V., Pessin, J. E., Judex, S., & Rubin, C. T. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080817 · Cited by 265 · see citing works
von Stengel, S., KEMMLER, W. K., Engelke, K., & Kalender, W. A. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1215-4 · Cited by 177 · see citing works
Oxlund, B. S., Ørtoft, G., Andreassen, T. T., et al. (2003) · Bone · doi:10.1016/s8756-3282(02)00916-x · Cited by 171 · see citing works
Rees, S. S., Murphy, A. J., & Watsford, M. L. (2008) · Physical Therapy · doi:10.2522/ptj.20070027 · Cited by 171 · see citing works
(1991) · Applied Ergonomics · doi:10.1016/0003-6870(91)90163-c · Cited by 139 · see citing works
Shi, H., Cheung, W., Qin, L., et al. (2009) · Bone · doi:10.1016/j.bone.2009.11.028 · Cited by 132 · see citing works
Self-citationLeung, K., Shi, H., Cheung, W., et al. (2008) · Journal of Orthopaedic Research® · doi:10.1002/jor.20753 · Cited by 125 · see citing works
Self-citationSunters, A., Armstrong, V. J., Zaman, G., Kypta, R. M., Kawano, Y., Lanyon, L. E., & Price, J. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.027086 · Cited by 122 · see citing works
CURRENT TRENDS IN THE ENHANCEMENT OF FRACTURE HEALING
Hannouche, D., Petite, H., & Sedel, L. (2001) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.83b2.12106 · Cited by 113 · see citing works
Bemben, D. A., Palmer, I. J., Bemben, M. G., & Knehans, A. W. (2010) · Bone · doi:10.1016/j.bone.2010.06.019 · Cited by 111 · see citing works
Enhancement of Fracture Healing by Mechanical and Surgical Intervention
Chao, E. Y. S., Inoue, N., Elias, J. J., et al. (1998) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199810001-00018 · Cited by 109 · see citing works
The molecular basis of bone mechanotransduction.
Yavropoulou, M. P., & Yovos, J. G. (2016) · PubMed Central · Cited by 105 · see citing works
Leung, K. S., Li, C. Y., Tse, Y. K., Choy, T. K., Leung, P. C., Hung, V., Chan, S., Leung, A. H.-C., & Cheung, W. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2693-6 · Cited by 102 · see citing works
Self-citationPlantar vibration improves leg fluid flow in perimenopausal women
Stewart, J. M., Karman, C., Montgomery, L. D., & McLeod, K. J. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00513.2004 · Cited by 96 · see citing works
Healing Patterns of Metaphyseal Fractures
Uhthoff, H. K., & Rahn, B. A. (1981) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198110000-00042 · Cited by 93 · see citing works
Muir, J. W., Kiel, D. P., & Rubin, C. T. (2013) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2013.01.004 · Cited by 86 · see citing works
Effects of Estrogen on Fracture Healing in Mice
Beil, F. T., Barvencik, F., Gebauer, M., Seitz, S. A., Rueger, J. M., Ignatius, A. A., Pogoda, P., Schinke, T., & Amling, M. (2010) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181c4544d · Cited by 83 · see citing works
Fuermaier, A. B. M., Tucha, L., Koerts, J., van Heuvelen, M. J. G., van der Zee, E. A., Lange, K. W., & Tucha, O. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090747 · Cited by 82 · see citing works
Human Mesenchymal Stromal Cells are Mechanosensitive to Vibration Stimuli
Kim, I., Song, Y., Lee, B., et al. (2012) · Journal of Dental Research · doi:10.1177/0022034512465291 · Cited by 76 · see citing works
Wehrle, E., Liedert, A., Heilmann, A., Wehner, T., Bindl, R., Fischer, L., Haffner‐Luntzer, M., Jakob, F. J., Schinke, T., Amling, M., et al. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.018622 · Cited by 74 · see citing works
Chow, D. H. K., Leung, K., Qin, L., et al. (2010) · Journal of Orthopaedic Research® · doi:10.1002/jor.21303 · Cited by 71 · see citing works
Self-citationGómez‐Cabello, A., González‐Agüero, A., Morales, S. G., Ara, I., Casajús, J. A., & Vicente‐Rodríguez, G. (2013) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2013.04.020 · Cited by 70 · see citing works
Sitjà‐Rabert, M., Martínez‐Zapata, M. J., Vanmeerhaeghe, A. F., Rey-Abella, F., Romero‐Rodríguez, D., & Bonfill, X. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.07.018 · Cited by 69 · see citing works
Stuermer, E. K., Komrakova, M., Werner, C., et al. (2010) · Calcified Tissue International · doi:10.1007/s00223-010-9381-0 · Cited by 68 · see citing works
Lam, T. P., Ng, B. K. W., Cheung, W., Lee, K. M., Qin, L., & Cheng, J. C. Y. (2012) · Osteoporosis International · doi:10.1007/s00198-012-2144-1 · Cited by 67 · see citing works
Self-citationKomrakova, M., Sehmisch, S., Tezval, M., et al. (2013) · Calcified Tissue International · doi:10.1007/s00223-013-9706-x · Cited by 62 · see citing works
Cheung, W., Sun, M.-H., Zheng, Y., et al. (2012) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2012.07.025 · Cited by 61 · see citing works
Self-citationEffects of High-Frequency, Low-Magnitude Mechanical Stimulus on Bone Healing
Wolf, S., Augat, P., Eckert-Hübner, K., Laule, A., Krischak, G. D., & Claes, L. (2001) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-200104000-00030 · Cited by 61 · see citing works
Wehrle, E., Wehner, T., Heilmann, A., Bindl, R., Claes, L., Jakob, F., Amling, M., & Ignatius, A. (2014) · Journal of Orthopaedic Research® · doi:10.1002/jor.22629 · Cited by 59 · see citing works
Felber, K., Elks, P. M., Lecca, M., & Roehl, H. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144982 · Cited by 59 · see citing works
Chung, S.-L., Leung, K., & Cheung, W. (2014) · Journal of Orthopaedic Research® · doi:10.1002/jor.22715 · Cited by 53 · see citing works
Self-citationKuroda, S., Virdi, A. S., Dai, Y. D., Shott, S., & Sumner, D. R. (2005) · Calcified Tissue International · doi:10.1007/s00223-004-0267-x · Cited by 52 · see citing works
Dumas, V., Ducharne, B., Perrier, A., et al. (2010) · Calcified Tissue International · doi:10.1007/s00223-010-9394-8 · Cited by 49 · see citing works
Stuermer, E. K., Komrakova, M., Sehmisch, S., et al. (2014) · Bone · doi:10.1016/j.bone.2014.04.008 · Cited by 47 · see citing works
Komrakova, M., Hoffmann, D. B., Nuehnen, V., Stueber, H., Waßmann, M., Wicke, M., Tezval, M., Stürmer, K. M., & Sehmisch, S. (2016) · Calcified Tissue International · doi:10.1007/s00223-016-0156-0 · Cited by 45 · see citing works
Wei, F.-Y., Chow, S. K., Leung, K. S., Qin, J., Guo, A., Yu, O., Li, G., & Cheung, W.-H. (2016) · European Cells and Materials · doi:10.22203/ecm.v031a22 · Cited by 44 · see citing works
Self-citationCURRENT TRENDS IN THE ENHANCEMENT OF FRACTURE HEALING
Hannouche, D., Petite, H., & Sedel, L. (2001) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.83b2.0830157 · Cited by 39 · see citing works
Chow, S. K., Leung, K., Qin, J., Guo, A., Sun, M., Qin, L., & Cheung, W. (2016) · Osteoporosis International · doi:10.1007/s00198-016-3619-2 · Cited by 37 · see citing works
Self-citationButezloff, M. M., Zamarioli, A., Leoni, G. B., et al. (2015) · Acta Cirúrgica Brasileira · doi:10.1590/s0102-865020150110000002 · Cited by 35 · see citing works
Usui, Y., Zerwekh, J. E., Vanharanta, H. V., et al. (1989) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100070414 · Cited by 32 · see citing works
Osteoprotegerin Enhances Osteogenesis of Human Mesenchymal Stem Cells
Palumbo, S. L., & Li, W. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0550 · Cited by 28 · see citing works
Role of Bone Regeneration and Turnover Modulators in Control of Fracture
Rozen, N., Lewinson, D., Bick, T., et al. (2007) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v17.i3.30 · Cited by 28 · see citing works
Effects of local vibration and pulsed electromagnetic field on bone fracture: A comparative study
Bilgin, H. M., Çelik, F., Gem, M., et al. (2017) · Bioelectromagnetics · doi:10.1002/bem.22043 · Cited by 24 · see citing works
Judex, S., Koh, T. J., & Xie, L. (2015) · Osteoporosis International · doi:10.1007/s00198-014-3018-5 · Cited by 17 · see citing works
Gao, J., Gong, H., Huang, X., et al. (2016) · Annals of Biomedical Engineering · doi:10.1007/s10439-015-1532-z · Cited by 17 · see citing works
Vibration acceleration promotes bone formation in rodent models
Uchida, R., Nakata, K., Kawano, F., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172614 · Cited by 15 · see citing works
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Methods to accelerate fracture healing – a narrative review from a clinical perspective
Ganse, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1384783 · Cited by 33 · see citing works
Vibration therapy as an effective approach to improve bone healing in diabetic rats
Campos, M. S., Volpon, J. B., Ximenez, J. P. B., Franttini, A. P., Dalloul, C. E., Sousa-Neto, M. D., Silva, R. A., Kacena, M. A., & Zamarioli, A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.909317 · Cited by 9 · see citing works
- Authors
- Department of Orthopaedics and Traumatology, P. O. W. H., Wang, J., Leung, K., Chow, S., & Cheung, W.
- Affiliations
- Chinese University of Hong Kong (HK)
- ORCID
- Wang, J
- Venue
- European Cells and Materials
- Publisher
- Forum Multimedia Publishing LLC
- Published
- 2017-09-07
- Volume
- 34
- Pages
- 108-127
- ISSN
- 1473-2262 (ISSN-L)
- OpenAlex
- W2752206022
- Cited by
- 45
- References
- 64
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 11 · 2019: 6 · 2018: 4
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- European Cells and Materials (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Effects of Vibration on Health
- Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- whole-body vibration, fracture healing, vibration frequency, ovariectomy, angiogenesis, bone regeneration, animal models
- MeSH terms
- Animals, Biomechanical Phenomena, Estrogens, Gene Expression Regulation, Humans, Vibration, Treatment Outcome, Fracture Healing, Neovascularization, Physiologic
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