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Cited by 88Antifungal resistance and susceptibilityInfection Control in HealthcareNosocomial Infections in ICU

The DOI matches its Crossref record; 43 of the 45 references it cites were found in a registry or an index.

Secular Trends in the Epidemiology of Nosocomial Fungal Infections at a Teaching Hospital in Taiwan, 1981 to 1993

Nettleman, Mary D., Chen, Yee-Chun, Chang, Shan-Chwen, Sun, Chun-Chuan, Yang, Li-Se, Hsieh, Wei-Chuan, Luh, Kwen-Tay·1997·Infection Control & Hospital Epidemiology
DOI 10.1086/647628
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Abstract

Objective: To describe the incidence and patterns of nosocomial fungal infection in a large teaching hospital in Taiwan. Design: Prospective, hospitalwide nosocomial surveillance data from 1981 through 1993 were analyzed to show the secular trend in nosocomial fungal infection rates and to identify the most common pathogens and sites of infection (other than skin) in this hospital. Setting and Patients: The National Taiwan University Hospital is a medical school-affiliated hospital in the city of Taipei, Taiwan, with a 1,200-bed capacity before 1991 and 1,500 beds since 1992. It provides both primary and tertiary medical care. Results: The overall nosocomial fungal infection rate rose from 0.9 infections per 1,000 discharges in 1981 to 6.6 per 1,000 discharges in 1993, with the highest rate at the medical intensive-care unit (26.5/1,000 discharges in 1993). This increase in infection rate was found at four major anatomic sites of infection, particularly including the bloodstream (0.08-2.19/1,000 discharges) and the urinary tract (0.36-2.95/1,000 discharges). Of 256 pathogens causing nosocomial fungemia from 1981 through 1993, Candida albicans was the most commonly isolated (50.8%), followed by Candida tropicalis (17.6%), Candida parapsilosis (11.7%), and Candida glabrata (8.2%). As compared to isolates from 1981 through 1988, the proportion of C parapsilosis and C glabrata isolated between 1989 and 1993 increased more than sixfold and fourfold, respectively. The increasing importance of fungal infections was confirmed further by the increased use of amphotericin B and azoles in this hospital. Conclusions: Candida species and other yeasts have become a prominent cause of nosocomial infections in this hospital. These fungal pathogens accounted for a higher proportion of nosocomial bloodstream and urinary infections than any single bacterial species. Therefore, it is important to conduct a prospective epidemiological study and to establish in vitro antifungal susceptibility testing to enhance efforts to control nosocomial fungal infections and to minimize the risk of emergence of antifungal resistance.

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Crossref · 10.1086/647628

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  1. 10.1016/S0002-9343(89)80392-4 · DOI · Paper page

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Metadata

Authors
Nettleman, M. D., Chen, Y.-C., Chang, S.-C., Sun, C.-C., Yang, L.-S., Hsieh, W.-C., & Luh, K.-T.
Affiliations
National Taiwan University Hospital (TW)
ORCID
Venue
Infection Control & Hospital Epidemiology
Publisher
Cambridge University Press (CUP)
Published
1997-05
Volume
18
Issue
5
Pages
369-375
ISSN
  • 0899-823X (ISSN-L)
  • 1559-6834
DOI
10.1086/647628
OpenAlex
W2071176269
Cited by
88
References
45
Citations by year
2021: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 4
FWCI
2.28
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified, 6455 d)
Locations
  • Infection Control and Hospital Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Keywords
nosocomial fungal infections, secular trends, Candida parapsilosis, Candida glabrata, Candida albicans, Candida tropicalis, bloodstream infection, urinary tract infection, intensive care unit, antifungal susceptibility, antifungal prophylaxis, amphotericin B, azoles, teaching hospitals, Taiwan, antifungal resistance
MeSH terms
Antifungal Agents, Candida, Candidiasis, Cross Infection, Hospitals, University, Humans, Mycoses, Population Surveillance, Prospective Studies, Respiratory Tract Infections, Surgical Wound Infection, Taiwan, Urinary Tract Infections, Incidence, Fungemia

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CoChat. (2026). Citation check: Secular Trends in the Epidemiology of Nosocomial Fungal Infections at a Teaching Hospital in Taiwan, 1981 to 1993. https://app.cochat.ai/papers/10.1086/647628
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Nettleman, M. D., Chen, Y.-C., Chang, S.-C., Sun, C.-C., Yang, L.-S., Hsieh, W.-C., & Luh, K.-T. (1997). Secular Trends in the Epidemiology of Nosocomial Fungal Infections at a Teaching Hospital in Taiwan, 1981 to 1993. Infection Control & Hospital Epidemiology. https://doi.org/10.1086/647628

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.