Antimicrobial and anti-adhesive properties of biosurfactant produced by lactobacilli isolates, biofilm formation and aggregation ability
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This study aimed to investigate the antimicrobial and anti-adhesive properties of biosurfactant extracted from ten lactobacilli species isolated from Egyptian dairy products. The produced biosurfactants showed distinct antimicrobial and anti-adhesive activities against several pathogenic microorganisms. Furthermore, lactobacilli isolates were studied for biofilm formation and lactic acid production in different growth media. All lactobacilli isolates produced biofilm on polystyrene surface in all media tested to different degrees. L. acidophilus showed the highest biofilm formation in Rogosa medium. However, the highest lactic acid production was recorded by L. brevis (39.63 g/L), followed by L. reuteri (33.32 g/L) in MRS medium. Evaluation based on in vitro studies including auto-aggregation and co-aggregation with three pathogenic bacterial strains was further analyzed. All lactobacilli isolates tested were able to auto-aggregate (ranging from 51.12% to 78.17% assessed at 5 h of incubation). The lactobacilli isolates co-aggregate with the tested bacterial strains to different degrees; among them L. delbrueckii showed the highest scores of co-aggregation with Candida albicans ATC70014, reaching 59.37%. The aggregation ability exhibited by the isolated lactobacilli, together with the antimicrobial and anti-adhesive properties observed for their biosurfactants, opens future prospects for their use against microorganisms responsible for diseases and infections and as effective probiotic strains.
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Co-aggregation between lactobacilli and pathogenic microorganisms helps form a barrier that stops their adherence to epithelia and subsequent access to tissues.
“As a crucial host defence mechanism against infections in the gastrointestinal and urogenital tracts, co-aggregation between lactobacilli and pathogenic microorganisms helps to form a barrier that stops their adherence to the epithelia and subsequent access to the tissues [47].”
From EVALUATION OF ADHESIVE AND AGGREGATION PROPERTIES OF LACTIC ACID BACTERIA ISOLATED FROM DIFFERENT BIOTOPES (2025) · cites this paper as [47]
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Lohinava, V. P. (2026) · Medical and Biological Problems of Life Activity · doi:10.58708/2074-2088.2026-1(37)-35-45
Thakkar, B., & Daxini, N. (2025) · Biosciences Biotechnology Research Asia · doi:10.13005/bbra/3460
Логинова, О. П., Шевченко, Н. Ю., & Гасич, Е. Л. (2025) · Лабораторная диагностика. Восточная Европа · doi:10.34883/pi.2025.14.4.004
- Authors
- Zakaria Gomaa, E.
- Venue
- The Journal of General and Applied Microbiology
- Publisher
- Microbiology Research Foundation
- Published
- 2013
- Volume
- 59
- Issue
- 6
- Pages
- 425-436
- ISSN
- 0022-1260 (ISSN-L)
- 1349-8037
- OpenAlex
- W2002579241
- Cited by
- 116
- References
- 0
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 12 · 2023: 15 · 2022: 12 · 2021: 16 · 2020: 8 · 2019: 8 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 5 · 2014: 3
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of General and Applied Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Physical Sciences › Environmental Science › Pollution › Microbial bioremediation and biosurfactants
- Keywords
- biosurfactants, lactobacilli, antimicrobial activity, anti-adhesion activity, biofilm formation, self-aggregation, co-aggregation, lactic acid production, probiotics, dairy products, pathogenic bacteria, Candida albicans, Lactobacillus acidophilus, Lactobacillus brevis, Lactobacillus reuteri, Lactobacillus delbrueckii
- MeSH terms
- Anti-Infective Agents, Bacterial Adhesion, Culture Media, Lactobacillus, Microbial Sensitivity Tests, Surface-Active Agents, Biofilms, Lactic Acid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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