The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Increased Number of Islet-Associated Macrophages in Type 2 Diabetes
Open accessAbstract
Activation of the innate immune system in obesity is a risk factor for the development of type 2 diabetes. The aim of the current study was to investigate the notion that increased numbers of macrophages exist in the islets of type 2 diabetes patients and that this may be explained by a dysregulation of islet-derived inflammatory factors. Increased islet-associated immune cells were observed in human type 2 diabetic patients, high-fat–fed C57BL/6J mice, the GK rat, and the db/db mouse. When cultured islets were exposed to a type 2 diabetic milieu or when islets were isolated from high-fat–fed mice, increased islet-derived inflammatory factors were produced and released, including interleukin (IL)-6, IL-8, chemokine KC, granulocyte colony-stimulating factor, and macrophage inflammatory protein 1α. The specificity of this response was investigated by direct comparison to nonislet pancreatic tissue and β-cell lines and was not mimicked by the induction of islet cell death. Further, this inflammatory response was found to be biologically functional, as conditioned medium from human islets exposed to a type 2 diabetic milieu could induce increased migration of monocytes and neutrophils. This migration was blocked by IL-8 neutralization, and IL-8 was localized to the human pancreatic α-cell. Therefore, islet-derived inflammatory factors are regulated by a type 2 diabetic milieu and may contribute to the macrophage infiltration of pancreatic islets that we observe in type 2 diabetes.
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Cites
Obesity is associated with macrophage accumulation in adipose tissue
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Inflammation, stress, and diabetes
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Interleukin-1-receptor antagonist in type 2 diabetes mellitus
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Self-citationIKK-β links inflammation to obesity-induced insulin resistance
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Multiple control of interleukin-8 gene expression
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An immune origin of type 2 diabetes?
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Cited by
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684
Inflammatory Mechanisms in Obesity
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Type 2 diabetes as an inflammatory disease
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Self-citationInflammatory links between obesity and metabolic disease
Lumeng, C. N., & Saltiel, A. R. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57132 · Cited by 2,319
Inflammation in obesity, diabetes, and related disorders
Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.013 · Cited by 2,066
Self-citation
Metadata
- Authors
- Ehses, J. A., Perren, A., Eppler, E., Ribaux, P., Pospisilik, J. A., Maor-Cahn, R., Gueripel, X., Ellingsgaard, H., Schneider, M. K. J., Biollaz, G., Fontana, A., Reinecke, M., Homo-Delarche, F., & Donath, M. Y.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2007-09-01
- Volume
- 56
- Issue
- 9
- Pages
- 2356-2370
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2113145530
- Cited by
- 783
- References
- 10
- FWCI
- 26.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Ehses, J. A., Perren, A., Eppler, E., Ribaux, P., Pospisilik, J. A., Maor-Cahn, R., Gueripel, X., Ellingsgaard, H., Schneider, M. K. J., Biollaz, G., Fontana, A., Reinecke, M., Homo-Delarche, F., & Donath, M. Y. (2007). Increased Number of Islet-Associated Macrophages in Type 2 Diabetes. Diabetes. https://doi.org/10.2337/db06-1650
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