The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance
Abstract
OBJECTIVE—We identified lipocalin 2 (Lcn2) as a gene induced by dexamethasone and tumor necrosis factor-α in cultured adipocytes. The purpose of this study was to determine how expression of Lcn2 is regulated in fat cells and to ascertain whether Lcn2 could be involved in metabolic dysregulation associated with obesity. RESEARCH DESIGN AND METHODS—We examined Lcn2 expression in murine tissues and in 3T3-L1 adipocytes in the presence and absence of various stimuli. We used quantitative Western blotting to observe Lcn2 serum levels in lean and obese mouse models. To assess effects on insulin action, we used retroviral delivery of short hairpin RNA to reduce Lcn2 levels in 3T3-L1 adipocytes. RESULTS— Lcn2 is highly expressed by fat cells in vivo and in vitro. Expression of Lcn2 is elevated by agents that promote insulin resistance and is reduced by thiazolidinediones. The expression of Lcn2 is induced during 3T3-L1 adipogenesis in a CCAAT/enhancer-binding protein–dependent manner. Lcn2 serum levels are elevated in multiple rodent models of obesity, and forced reduction of Lcn2 in 3T3-L1 adipocytes improves insulin action. Exogenous Lcn2 promotes insulin resistance in cultured hepatocytes. CONCLUSIONS— Lcn2 is an adipokine with potential importance in insulin resistance associated with obesity.
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Cites
1 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
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Self-citationReactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · cited 2×
“Glucose uptake was determined as previously reported (15).”
Self-citationAdipocytes as regulators of energy balance and glucose homeostasis
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“The discovery of leptin more than a decade ago established a paradigm in which secreted proteins from adipocytes coordinate energy balance and glucose homeostasis (2,3).”
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
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Self-citationThe lipocalin protein family: structure and function
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Cited by
Adipokines in inflammation and metabolic disease
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What we talk about when we talk about fat
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Self-citationMetabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
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Adipokine dysregulation and adipose tissue inflammation in human obesity
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Metadata
- Authors
- Yan, Q.-W., Yang, Q., Mody, N., Graham, T. E., Hsu, C.-H., Xu, Z., Houstis, N. E., Kahn, B. B., & Rosen, E. D.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2007-10-01
- Volume
- 56
- Issue
- 10
- Pages
- 2533-2540
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2169392626
- Cited by
- 467
- References
- 13
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yan, Q.-W., Yang, Q., Mody, N., Graham, T. E., Hsu, C.-H., Xu, Z., Houstis, N. E., Kahn, B. B., & Rosen, E. D. (2007). The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance. Diabetes. https://doi.org/10.2337/db07-0007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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