Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I

Turner, Nigel, Li, Jing-Ya, Gosby, Alison, To, Sabrina W.C., Cheng, Zhe, Miyoshi, Hiroyuki, Taketo, Makoto M., Cooney, Gregory J. +5 more·2008·Diabetes

DOI 10.2337/db07-1552

Cited by (541)

Items 301–400 of 541

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Joungmok Kim, Joonsoo Shin, Joohun Ha · 2014 · Expert Opinion on Therapeutic Patents
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