Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I

Turner, Nigel, Li, Jing-Ya, Gosby, Alison, To, Sabrina W.C., Cheng, Zhe, Miyoshi, Hiroyuki, Taketo, Makoto M., Cooney, Gregory J. +5 more·2008·Diabetes
DOI 10.2337/db07-1552

Cited by (541)

Items 401–500 of 541

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  14. Mécanisme d’action hépatique de la metformine dans le diabète de type 2
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  15. Plant-derived immunomodulators in cancer: Balancing immune activation and suppression within the tumor microenvironment
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  17. Berberine augments hypertrophy of colonic patches in mice with intraperitoneal bacterial infection
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  18. Berberine mitigates colitis-associated neuroinflammation and anxiety through modulation of the AMPK/NURR1 pathway
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  19. Targeting mitochondria: a great boon to fight type 2 diabetes
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  20. In Vitro Production of Alkaloids
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  21. In Silico and In Vitro Approach to Assess Direct Allosteric AMPK Activators from Nature
    Benjamin Kirchweger, Andreas Wasilewicz, Katrin Fischhuber, Ammar Tahir, Ya Chen, Elke H. Heiß, Thierry Langer, Johannes Kirchmair, Judith Maria Rollinger · 2022 · Planta Medica
  22. Mitochondrial Metabolism and Insulin Action
    Nigel A. Turner · 2013 · InTech eBooks
  23. WSF-P-1, a novel AMPK activator, promotes adiponectin multimerization in 3T3-L1 adipocytes
    Yao Wang, Yudian Zhang, Yunyun Wang, Peng Han, Rui Jian, Zhijie Zhang, Shifa Wang, Zhen Li · 2017 · Bioscience Biotechnology and Biochemistry
  24. Berberine Analogues: Progress towards Versatile Applications
    Fan Yang, Jing Wang, Jie Tang, Li-Fang Yu, Jia Li, Jing-Ya Li · 2015 · Heterocycles
  25. GC-MS Analysis of Amur Cork Tree Extract and Its Degradation Products
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  26. The effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analysis
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  27. Berberine: A Negentropic Modulator for Multi-System Coordination
    X L Tian, Qingbo Chen, Yi He, Yangyang Cheng, Mengyu Zhao, Y W Li, Miao Yu, Jiandong Jiang, Lulu Wang · 2026 · International Journal of Molecular Sciences
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  30. Advances in natural small molecules on pretranslational regulation of gluconeogenesis
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  32. [Drug discovery based on classic natural products].
    Lihong Hu, Jiqing Xu · 2009 · PubMed
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    Tatsuro, Tatsuro Egawa, Rieko Oshima, Oshima, Eriko, Kurogi, Hiroko, Tanabe, Satoshi Satoshi, Tsuda et al. · 2011 · Chinese Journal of Natural Medicines
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    Licht Miyamoto · 2016 · Food Science and Biotechnology
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  75. Diabetes Treatment and Prevention Using Herbal Medicine
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  79. How to use the monographs
    2013 · Elsevier eBooks
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    Yi Zhao · 2015
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    Jude Chenge · 2012 · ScholarWorks - GVSU (Grand Valley State University)
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  86. Caffeine and Insulin-Independent Glucose Transport
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  87. La régulation du transport du glucose dans le muscle squelettique : l'implication des protéines AMPK et iNOS
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  88. AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer
    Novartis Medal Lecture · 2011
  89. Hijacking the Candida albicans Multidrug Resistant Transporter MDR1 to Potentiate Antifungal Activity
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  90. The Association between Metformin Therapy and Mortality Following Breast Cancer: A Population-based Study
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  91. Overcoming Tumor Drug Resistance By Activating Amp-Activated Protein Kinase And Destabilizing Oncoproteins
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  93. Effects of AMP-activated kinase modulators on intracellular Ca2+ signalling and C. elegans lifespan
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  94. Impact of Diabetes and its pharmacological treatment on cardiovascular function: studies on ischaemia-reperfusion models
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  95. Contribution of Gut Microbiome to Human Health and the Metabolism or Toxicity of Drugs and Natural Products
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  97. IF1 connects obesity and insulin resistance through mitochondrial reprogramming in association with ANT2
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  98. Natural Phenolic Compounds Targeting The AMPK Activation For Metabolic Health
    Khoa D.A Nguyen, Khanh V. Doan · 2021
  99. The Effects of Chromium on Skeletal Muscle Membrane/Cytoskeletal Parameters and Insulin Sensitivity
    Nolan J. Hoffman · 2012 · IUScholarWorks (Indiana University)
  100. References
    2016 · CRC Press eBooks